The spread of the global COVID-19 epidemic, home quarantine, and blockade of infected areas are essential measures to prevent the spread of the epidemic, but efforts to prevent and control the outbreak lead to the disruption of fresh and cold chain agricultural products in the region. Based on the multi-layer management model of non-scale agricultural households in China, we applied the complex network theory to construct an evolutionary model of the Chinese fresh cold chain network with adaptation degree priority connection, dual local world considering transport distance connection relationship, and superiority and inferiority mechanism. Based on this model, we studied the evolution of fresh cold chain disruption, and puts forward the optimal design of fresh cold chain network disruption and reconnection from the perspective of practicality and economy.