PREVEntion and regReSsive Effect of weight-loss and risk factor modification on Atrial Fibrillation: the REVERSE-AF study

Abstract

Obesity is associated with progression of the AF disease. This study demonstrates the dynamic relationship between weight/risk factors and AF. Weight-loss management and RFM reverses the type and natural progression of AF.

Influence of risk factors in the ESC‐EHRA EORP atrial fibrillation ablation long‐term registry

“…After a mean follow‐up of 46 ± 32 months, recurrence was 70% in obese patients and 54% in nonobese patients off antiarrhythmic drugs (44% and 32% on antiarrhythmic drugs). In addition, an intensive weight loss program has been shown to increase absence of AF after ablation and regression of AF without ablation . In conclusion, our findings of an increased incidence of arrhythmia recurrence in the group of patients with risk factors and the specific influence of hypertension and BMI, therein is in line with other literature.…”

“…11 shown to increase absence of AF after ablation and regression of AF without ablation. 14,15 In conclusion, our findings of an increased incidence of arrhythmia recurrence in the group of patients with risk factors and the specific influence of hypertension and BMI, therein is in line with other literature.…”

Prevalence and Incidence of Atrial Fibrillation in the General Population Based on National Health Insurance Special Health Checkups ― TAMA MED Project-AF ―

“…21 In a recent report of the REVERSE-AF study to evaluate the impact of body weight and risk factor management on the progression of AF, ≥10% weight loss resulted in 88% who reversed from persistent AF to paroxysmal or no AF. 23 Body weight control would also be an important strategy to prevent new-onset AF.…”

Reducing risk of adverse cardiovascular and renal outcomes for patients with atrial fibrillation and type 2 diabetes

“…The decision whether to initiate rhythm or rate control should be individualised based on symptoms and should consider the type of AF (paroxysmal, persistent, or long‐standing persistent), co‐morbidities and current medications. C: Cardiovascular risk and co‐morbidity management. Underlying risk factors contributing to stroke risk and co‐morbidities such as type 2 diabetes should be prioritised including managing lifestyle risk factors, for instance discussion of weight management and a tailored programme of diet changes and exercise for patients with obesity . Dose‐reduced regimens of anticoagulants may be considered depending on the age of the patient and presence of other risk factors such as impaired renal function .…”

“…Underlying risk factors contributing to stroke risk and co-morbidities such as type 2 diabetes should be prioritised including managing lifestyle risk factors, for instance discussion of weight management and a tailored programme of diet changes and exercise for patients with obesity 13. Dose-reduced regimens of anticoagulants may be considered depending on the age of the patient and presence of other risk factors such as impaired renal function.…”