Prevention and treatment of chemotherapy- and radiotherapy-induced oral mucositis: a review

Plevová, Pavlína

doi:10.1016/s1368-8375(99)00033-0

Cited by 110 publications

(103 citation statements)

References 161 publications

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“…Publicações mostram o uso do laser de hélio/neônio como um agente capaz de reduzir a intensidade da mucosite oral e da dor em pacientes submetidos a RT e QT e de pacientes submetidos a transplante autólogo de medula e a RT e QT (31)(32)(33)(34)(35) . Trabalhos publicados mostram a eficá-cia do LBP como um agente estimulador da salivação em pacientes portadores de xerostomia, sialoadenites e síndrome de Sjögren (36)(37)(38)(39) .…”

Section: Introductionunclassified

Prevenção da xerostomia e da mucosite oral induzidas por radioterapia com uso do laser de baixa potência

Lopes¹,

Mas

Zângaro

2006

Radiol Bras

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OBJETIVO: Verificar se o uso do laser de InGaAlP com comprimento de onda de 685 nm pode reduzir a incidência de xerostomia, gravidade da mucosite oral e da dor associada à mucosite em pacientes portadores de câncer de cabeça e pescoço submetidos a radioterapia. MATERIAIS E MÉTODOS: Sessenta pacientes portadores de carcinoma de cabeça e pescoço foram submetidos a radioterapia com dose diária de 1,8 a 2,0 Gy e dose final de 45 a 72 Gy. O volume salivar foi medido nos dias um, 15, ao final do tratamento e após 15 e 30 dias, e a mucosite oral em avaliações semanais. Vinte e nove pacientes se submeteram a radioterapia sem laser e 31 foram submetidos a radioterapia e laser com dose diária de 2 joules/cm² em pontos pré-determinados da mucosa oral e glândulas parótida e submandibular. RESULTADOS: No grupo submetido a radioterapia e laser, a incidência de mucosite (F < 0,001) e dor (F < 0,016) foram significativamente menores e o volume salivar se manteve maior (F < 0,001) durante e após o tratamento. CON-CLUSÃO: Os pacientes submetidos à associação de radioterapia e laser tiveram menor incidência de xerostomia, mucosite oral e dor quando comparados ao grupo de radioterapia sem laser, com resultados com significância estatística. Unitermos: Laser de baixa potência; Xerostomia; Mucosite; Radioterapia; Quimioterapia.Low level laser therapy in the prevention of radiotherapy-induced xerostomia and oral mucositis. OBJECTIVE: To verify if the use of InGaAIP laser with 685 nm wave length can reduce the xerostomy incidence, the oral mucositis severity and the pain related to mucositis in patients with head and neck cancer submitted to radiotherapy. MATERIALS AND METHODS: Sixty patients presenting head and neck carcinoma were submitted to radiotherapy with daily doses of 1.8 to 2.0 Gy and a final dose of 45 to 72 Gy. The salivary volume was evaluated in the first and fifteenth days, at the end of the treatment and after 15 and 30 days. The oral mucositis was evaluated on a weekly basis. Twenty-nine patients were submitted to radiotherapy without laser and 31 were submitted to radiotherapy and laser with daily doses of 2 joules/ cm² in predetermined areas of the oral mucosa and the parotid and submandibular glands. RESULTS: In the group submitted to radiotherapy and laser the incidence of mucositis (F < 0.001) and pain (F < 0.016) was significantly lower and the salivary volume (F < 0.001) was kept higher during and after the treatment. CONCLUSION: The group of patients submitted to radiotherapy and laser had lower incidence of xerostomy, oral mucositis and pain when compared to the group treated with radioteraphy without laser, producing statistically significant results. Keywords: Low level laser; Xerostomy; Mucositis; Radiotherapy; Chemotherapy.Resumo Abstract * Trabalho realizado no Instituto de Radioterapia do Vale do Paraíba, São José dos Campos, SP.

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Section: Introductionunclassified

Prevenção da xerostomia e da mucosite oral induzidas por radioterapia com uso do laser de baixa potência

Lopes¹,

Mas

Zângaro

2006

Radiol Bras

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“…Various chemical substances have been tested for this purpose [10,16,20,23,24,28] and chlorhexidine has shown excellent results regarding the promotion of oral health, reducing the severity and duration of mucositis in patients with ALL submitted to chemotherapy and in a state of severe neutropenia [29][30][31]. However, chlorhexidine should be used at concentrations proven to be therapeutic due to its damaging effect on the epithelium of the oral mucosa as reported by Pereira Pinto et al [32].…”

Section: Discussionmentioning

confidence: 99%

“…These measures range from the intensification of oral hygiene care [19] to the use of different substances including sodium bicarbonate [20], saline solution, granulocyte colony-stimulating factor, granulocytemacrophage colony-stimulating factor, herbal medicines such as Oren-gedoku-to and Syousaikotou [21,22], and chlorhexidine, among others [10,16,20,23,24].…”

Section: Introductionmentioning

confidence: 99%

Prevention of oral lesions in children with acute lymphoblastic leukemia

Pinto

Souza

Gordón-Núñez

et al. 2006

International Journal of Pediatric Otorhinolaryngology

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Summary Acute lymphoblastic leukemia (ALL) is the most common form of cancer in children and is responsible for severe stomatologic complications. Treatment consists of four phases of chemotherapy, the main side effect of methotrexate, the drug most used during the intensification phase, is oral mucositis. Objective: To evaluate the clinical aspects of the oral mucosa of children with ALL and to determine the effect of 0.12% chlorhexidine gluconate on the prevention of stomatologic complications in these patients. Patients and methods: Thirty-three children treated for ALL ranging in age from 2 to 15 years, without distinction of gender or race, were submitted to visual examination, digital palpation of the oral mucosa and cytologic examination of the buccal mucosa, and divided into two groups: group I consisted of 23 children using an oral solution of 0.12% chlorhexidine gluconate twice a day, and group II consisted of 10 children who did not receive this solution. All children received daily oral hygiene care guided by the dentist throughout treatment. Results: Mucositis was observed in six children of group I and eight of group II, and was characterized by erythema, edema and ulcers. Uniform cytologic findings were

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“…Diversos autores ressaltam a importância do controle da microbiota bucal e a sua interferência no sentido do agravamento da mucosite oral (EPSTEIN; LOCKART;SONIS, 1981b;PLEVOVA, 1999;SCHUBERT et al, 1992). Os trabalhos que avaliaram a influência de um bom controle de higiene bucal na expressão de mucosites associadas a tratamentos anti-neoplásicos suportam esse fato (BOROWSKI et al, 1994;BONNAURE-MALLET et al, 1998).…”

Section: Discussionunclassified

“…FERNANDES; SILVA, 2000;BENSADOUN et al, 2001;PLEVOVA, 1999). A estomatotoxicidade direta é vista 5 a 7 dias após a administração de quimioterapia ou radioterapia.…”

Section: Mucosite Oralunclassified

Laser de baixa potência na prevenção de mucosite em pacientes submetidos à quimioterapia com fluorouracil e ácido folínico

Gambirazi¹

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Prevention and treatment of chemotherapy- and radiotherapy-induced oral mucositis: a review

Cited by 110 publications

References 161 publications

Prevenção da xerostomia e da mucosite oral induzidas por radioterapia com uso do laser de baixa potência

Prevenção da xerostomia e da mucosite oral induzidas por radioterapia com uso do laser de baixa potência

Prevention of oral lesions in children with acute lymphoblastic leukemia

Laser de baixa potência na prevenção de mucosite em pacientes submetidos à quimioterapia com fluorouracil e ácido folínico

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