Prevention and treatment of COVID-19-associated hypercoagulability: Recommendations of the Algerian society of transfusion and hemobiology

Abstract

Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, has spread throughout the world. Coagulation dysfunction is one of the major causes of death in patients with severe COVID-19. Several recent observations in Algeria and elsewhere maintain that a pulmonary embolism is frequent in patients with COVID-19 with a high incidence in intensive care. In addition, other studies have shown that many deceased patients have diagnostic criteria for disseminated intravascular coagulation (DIC) set by the International Society of Hemostasis and Thrombosis (ISTH) The office of the Algerian Society of Transfusion and Hemobiology composed of hemostasis and blood transfusion experts from Algerian hospitals on the epidemic front line have established a consensus on the issue through 4 axes: Indication of thromboprophylaxis, monitoring of hemostasis, indications of transfusion in the event of Disseminated Intravascular Coagulation (DIC) and anticoagulant treatment after discharge

International alliance and AGREE-ment of 71 clinical practice guidelines on the management of critical care patients with COVID-19: a living systematic review

“…Seventy-one CPGs were included, 45 were published in English, seven in Chinese, seven in Italian, five in Spanish, five in German, and two in French. [24] , [25] , [26] , [27] , [28] , [29] , [30] , [31] , [32] , [33] , [34] , [35] , [36] , [37] , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [46] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [55] , [56] , [57] , [58] , [59] , [60] , [61] , [62] , [63] , [64] , [65] , [66] , [67] , [68] , [69] , [70] , [71] , [72] , [73] , [74] , [75] , [76] , [77] , [78] , [79] , [80] , [81] , [82] , [83] , [84] , [85] , [86] , ...…”

“…(GRADE Method utilized) 6/1/2020 Authorship group of the article Affiliations of authors Gastrointestinal bleeding prophylaxis, gastroenterology, Critical care Chekkal (SATH) 83 English Algeria (LMIC) NHS National Summary of international CPGs with a local consensus opinion. 3/10/2020 Algerian society of transfusion and hemobiology (SATH) Professional Society Thromboprophylaxis, Hematology, critical care Goldenberg [84] English NA NA International Consensus of expert opinions 28/8/2020 Pediatric/Neonatal Hemostasis and Thrombosis Subcommittee of the ISTH Scientific and Standardization Committee (SSC) Affiliations of authors Thromboprophylaxis, Hematology, critical care, Pediatrics Henderson (ACR) 85 English USA (HIC) PHS National Consensus of expert opinions using a modified Delphi process 11/2020 American College of Rheumatology (ACR) Professional Society Multisystem Inflammatory Syndrome (MIS-C), Pediatrics, Critical Care Kache [86] English NA NA International Expert opinion (Informal) Guideline Adaptation 07/07/2020 Authorship group of the article Affiliations of authors Critically ill pediatric patients infected with COVID-19 (Pediatrics, Critical/ Intensive Care) Kakkar [87] English India (LMIC) NA local Methods NOT reported Sep/2020 Authorship group of the article Affiliations of authors Acute Ischemic Stork Management/prevention Kranke [88] …”

“…Scores of 51 CPGs (72% of eligible CPGs) were ≥60% in domain 4. [ 24 , 26 , 28 , 29 , [31] , [32] , [33] , 35 , 36 , [38] , [39] , [40] , [41] , [42] , [43] , [44] , [45] , [47] , [48] , [49] , [50] , [51] , [52] , [53] , [54] , [56] , [57] , [58] , [59] , [60] , [61] , [63] , [64] , [65] , [66] , [67] , [69] , [70] , [71] , 73 , 74 , 77 , 79 , [82] , [83] , [84] , [85] , [86] , 90 , 92 , 94 ]…”

“…Scores of 25 CPGs were ≥60%. [ [35] , [36] , [37] , [38] , [41] , [42] , [43] , 48 , 49 , 51 , 53 , 57 , 59 , 63 , 69 , 71 , 74 , 76 , 79 , [81] , [82] , [83] , [84] , 88 , 95 ]…”

“…Fourteen CPGs (20%) scored greater than 60%. [26] , [ 31 , 35 , [47] , [48] , [49] , [50] , [51] , 59 , 60 , 67 , 68 , 83 , 84 ] The authors relied on the ratings of domain 3 as the basis for classification of the quality of the specific CPG ( Table 2 and Table 3 ).…”