Prevention and Treatment of Diabetes Using Polyphenols via Activation of AMP‐Activated Protein Kinase and Stimulation of Glucagon‐like Peptide‐1 Secretion

Tsuda, Takanori

doi:10.1002/9781118883303.ch10

Cited by 3 publications

(8 citation statements)

References 59 publications

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“…The serine/threonine kinase AMPK is expressed in most eukaryotic cells; its activation induces glucose utilization in skeletal muscle and enhances fatty acid oxidation in the liver . These metabolic changes result in decreased body fat accumulation .…”

Section: Resultsmentioning

confidence: 99%

α-Monoglucosyl Hesperidin but Not Hesperidin Induces Brown-Like Adipocyte Formation and Suppresses White Adipose Tissue Accumulation in Mice

Nishikawa

Hyodo

Nagao

et al. 2019

J. Agric. Food Chem.

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Hesperidin (HES) is a flavanone glycoside found in citrus peel that contributes to its bitter taste. It has low water solubility and poor oral bioavailability. To improve its solubility and bioavailability, α-monoglucosyl hesperidin (αGH) has been synthesized from HES by transglucosylation using cyclodextrin glucanotransferase. Several reports indicate that αGH significantly decreases body fat, but the underlying molecular mechanism remains unclear. We hypothesized that the antiobesity effects of αGH occur through the induced formation of brown-like adipocytes. The present study verified that dietary αGH induces brown-like adipocytes to form in mouse inguinal white adipose tissue (iWAT), thereby significantly decreasing the weight of white adipose tissue (WAT). Furthermore, dietary αGH significantly induced thermogenesis in iWAT. Dietary αGH also significantly suppressed high-fat-diet-induced WAT accumulation in mice, which may be mediated by brown-like adipocyte formation. These results indicate that dietary αGH induces increased energy expenditure by stimulating the formation of brown-like adipocytes.

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Section: Resultsmentioning

confidence: 99%

α-Monoglucosyl Hesperidin but Not Hesperidin Induces Brown-Like Adipocyte Formation and Suppresses White Adipose Tissue Accumulation in Mice

Nishikawa

Hyodo

Nagao

et al. 2019

J. Agric. Food Chem.

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“…Activation of AMPK in skeletal muscle results in a significant increase in Glut4 protein expression in PM, which enhances glucose uptake into skeletal muscle via an insulin-independent mechanism (8). This enhanced glucose uptake can help ameliorate hyperglycemia in type 2 diabetic mice (8,15,16). The suppression of gluconeogenesis via downregulation of the rate-limiting enzymes (PEPCK and G6Pase) is also effective in improving hyperglycemia.…”

Section: Discussionmentioning

confidence: 99%

“…The activation of AMPK stimulates the energy production system and suppresses the synthesis of glucose and fat. AMPK is recognized as a crucial target for the prevention and treatment of type 2 diabetes (8). Activation of AMPK stimulates upregulation of Glut4 expression or translocation to the plasma membrane (PM) via an insulin-independent mechanism (8).…”

Section: Dietary Bce Significantly Induces Phosphorylation Of Ampk Anmentioning

confidence: 99%

“…Glucagon-like peptide-1 (GLP-1) and AMP-activated protein kinase (AMPK) are considered to be among the most significant molecular targets for prevention and treatment of diabetes (8). GLP-1 is an important molecular target in light of the diabetes-preventing and -suppressing effects of dietary factors.…”

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confidence: 99%

“…GLP-1 is a type of incretin, secreted from enteroendocrine L-cells, that stimulates glucose-dependent insulin secretion and the proliferation of pancreatic b-cells (9-11). There is generally considered to be a close relationship between incretin and diet, and increase of endogenous GLP-1 secretion by dietary factors is one of the important strategies for prevention and treatment of diabetes (8,12). Similar to GLP-1, AMPK is a serine/threonine kinase expressed in most eukaryotic cells, and the activation of AMPK induces an increase of cellular glucose uptake, which follows the membrane translocation of glucose transporter 4 (Glut4) in the skeletal muscle, and the suppression of gluconeogenesis in the liver, and results in improving hyperglycemia (8).…”

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confidence: 99%

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Blackcurrant Extract Ameliorates Hyperglycemia in Type 2 Diabetic Mice in Association with Increased Basal Secretion of Glucagon-Like Peptide-1 and Activation of AMP-Activated Protein Kinase

Iizuka

Ozeki

Tani

et al. 2018

J Nutr Sci Vitaminol

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Blackcurrants are berries that contain high levels of anthocyanins, particularly delphinidin 3-rutinoside (D3R). Several studies have reported that the consumption of blackcurrant extract (BCE) lowers blood glucose levels and ameliorates glucose tolerance, but the mechanism underlying this effect remains unclear. Glucagon-like peptide-1 (GLP-1) and AMP-activated protein kinase (AMPK) are considered one of the most significant molecular targets for the prevention and treatment of type 2 diabetes. In this study, we showed that dietary BCE significantly reduced blood glucose concentration and improved glucose tolerance in type 2 diabetic mice (KK-A). The basal GLP-1 concentration in plasma was significantly increased in the BCE group accompanied by upregulation of prohormone convertase 1/3 (PC1/3), the enzyme that processes intestinal proglucagon. Moreover, the level of phospho-AMPKα protein in skeletal muscle was significantly increased in the BCE group, and this was increase accompanied by significant upregulation of glucose transporter 4 (Glut4) proteins in the plasma membrane of BCE group. In conclusion, dietary BCE significantly reduced blood glucose concentration and improved glucose tolerance in association with increased basal GLP-1 concentration in plasma, upregulation of PC1/3 expression, and translocation of Glut4 to the plasma membrane of skeletal muscle in type 2 diabetic mice; furthermore, these effects were accompanied by activation of AMPK. Our findings demonstrated that D3R-rich BCE may help prevent diabetes and allow the dosages of diabetes drugs to be reduced.

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Anthocyanins’ effects on diabetes mellitus and islet transplantation

Liu

Wang

et al. 2022

Critical Reviews in Food Science and Nutrition

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Prevention and Treatment of Diabetes Using Polyphenols via Activation of AMP‐Activated Protein Kinase and Stimulation of Glucagon‐like Peptide‐1 Secretion

Cited by 3 publications

References 59 publications

α-Monoglucosyl Hesperidin but Not Hesperidin Induces Brown-Like Adipocyte Formation and Suppresses White Adipose Tissue Accumulation in Mice

α-Monoglucosyl Hesperidin but Not Hesperidin Induces Brown-Like Adipocyte Formation and Suppresses White Adipose Tissue Accumulation in Mice

Blackcurrant Extract Ameliorates Hyperglycemia in Type 2 Diabetic Mice in Association with Increased Basal Secretion of Glucagon-Like Peptide-1 and Activation of AMP-Activated Protein Kinase

Anthocyanins’ effects on diabetes mellitus and islet transplantation

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