Prevention and treatment of DNA vaccine encoding cockroach allergen Bla g 1 in a mouse model of allergic airway inflammation

Zhou, Bin; Ensell, M.; Zhou, Yixuan; Nair, Usha; Glickstein, J.; Kermany, Mohammad Habiby; Cai, Qing-Qing; Cai, Chun; Liu, W.; Deng, Yunping; Kakigi, Akinobu; Barbieri, Marco; Mora, Massimilliano; Kanangat, Siva; Yoo, T.J.

doi:10.1111/j.1398-9995.2011.02727.x

Cited by 8 publications

(5 citation statements)

References 34 publications

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“…Nevertheless, the use of animal models to study the association between obesity and asthma has been shown to be of relevance , and environmental‐related factors (allergens and diet) are specially relevant for the obesity and asthma epidemics seen in Western countries . Moreover, experiments required to fully understand the cellular and molecular mechanisms must be performed in animals for ethical reasons, specially those testing pharmacological agents . However, when extrapolating data from mice to humans, care should be taken with anatomical differences in respiratory tract, types of adjuvants, chronicity of the disease, and age of animals (infants vs adults).…”

Section: Discussionmentioning

confidence: 99%

Substance P antagonist improves both obesity and asthma in a mouse model

Ramalho

Almeida

Beltrão

et al. 2012

Allergy

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Section: Discussionmentioning

confidence: 99%

Substance P antagonist improves both obesity and asthma in a mouse model

Ramalho

Almeida

Beltrão

et al. 2012

Allergy

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“…The in vivo expression of the cloned gene is driven by the eukaryotic promotor over much longer periods of time as compared to protein antigens [90]. The DNA vaccine thereby better primes the immune system to offer long term immune memory and potentially support tolerance induction via promoting Treg cell responses [91,92]. Moreover, the built-in CpG motifs in the DNA vaccine backbone activate toll-like receptor 9 (TLR9) that leads to the activation of MyD88-dependent signaling pathways which drive Th1-oriented immune responses [93].…”

Section: Dna Vaccinementioning

confidence: 99%

Overcoming Shellfish Allergy: How Far Have We Come?

Wai

Leung

Chu

et al. 2020

IJMS

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Shellfish allergy caused by undesirable immunological responses upon ingestion of crustaceans and mollusks is a common cause of food allergy, especially in the Asia-Pacific region. While the prevalence of shellfish allergy is increasing, the mainstay of clinical diagnosis for these patients includes extract-based skin prick test and specific IgE measurement while clinical management consists of food avoidance and as-needed use of adrenaline autoinjector should they develop severe allergic reactions. Such a standard of care is unsatisfactory to both patients and healthcare practitioners. There is a pressing need to introduce more specific diagnostic methods, as well as effective and safe therapies for patients with shellfish allergy. Knowledge gained on the identifications and defining the immuno-molecular features of different shellfish allergens over the past two decades have gradually translated into the design of new diagnostic and treatment options for shellfish allergy. In this review, we will discuss the epidemiology, the molecular identification of shellfish allergens, recent progress in various diagnostic methods, as well as current development in immunotherapeutic approaches including the use of unmodified allergens, hypoallergens, immunoregulatory peptides and DNA vaccines for the prevention and treatment of shellfish allergy. The prospect of a “cure “for shellfish allergy is within reach.

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“…Overall, the main data, shown in key review papers, highlighted the capacity of DNA plasmid encoding allergens to prevent or revert the Th2-biased parameters of the allergic response (as airway eosinophilia, specific IgE and Th2 cytokines as IL-4, IL-5) through the development of allergen-specific Th1 responses characterized by interferon (IFN)g release and induction of specific IgG antibodies [9,10,15]. Some studies evidenced as well the ability of DNA vaccines to activate Treg cells as well as IL-10/TGF-b but mainly when co-administrated with protein allergen [16][17][18] (Fig. 1).…”

Section: Dna Vaccination In the Context Of Allergic Diseases: Mode Of...mentioning

confidence: 99%

Nucleic acid vaccines and CpG oligodeoxynucleotides for allergen immunotherapy

Jacquet

2021

Current Opinion in Allergy &Amp; Clinical Immunology

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Purpose of reviewMolecular forms of allergen-specific immunotherapy (AIT) are continuously emerging to improve the efficacy of the treatment, to shorten the duration of protocols and to prevent any side effects. The present review covers the recent progress in the development of AIT based on nucleic acid encoding allergens or CpG oligodeoxynucleotides (CpG-ODN). Recent findingsTherapeutic vaccinations with plasmid deoxyribonucleic acid (DNA) encoding major shrimp Met e 1 or insect For t 2 allergen were effective for the treatment of food or insect bite allergy in respective animal models. DNA expressing hypoallergenic shrimp tropomyosin activated Foxp3 þ T regulatory (Treg) cells whereas DNA encoding For t 2 down-regulated the expression of pruritus-inducing IL-31. Coadministrations of major cat allergen Fel d 1 with high doses of CpG-ODN reduced Th2 airway inflammation through tolerance induction mediated by GATA3 þ Foxp3 hi Treg cells as well as early antiinflammatory TNF/TNFR2 signaling cascade. Non-canonical CpG-ODN derived from Cryptococcus neoformans as well as methylated CpG sites present in the genomic DNA from Bifidobacterium infantis mediated Th1 or Treg cell differentiation respectively. SummaryRecent studies on plasmid DNA encoding allergens evidenced their therapeutic potential for the treatment of food allergy and atopic dermatitis. Unmethylated or methylated CpG-ODNs were shown to activate dose-dependent Treg/Th1 responses. Large clinical trials need to be conducted to confirm these promising preclinical data. Moreover, tremendous success of messenger ribonucleic acid (mRNA) vaccines against severe acute respiratory syndrome coronavirus 2 must encourage as well the re-exploration of mRNA vaccine platform for innovative AIT.

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Prevention and treatment of DNA vaccine encoding cockroach allergen Bla g 1 in a mouse model of allergic airway inflammation

Abstract: DNA vaccination showed protective and therapeutic efficacy against a clinically relevant allergen Bla g 1.

Cited by 8 publications

References 34 publications

Substance P antagonist improves both obesity and asthma in a mouse model

Substance P antagonist improves both obesity and asthma in a mouse model

Overcoming Shellfish Allergy: How Far Have We Come?

Nucleic acid vaccines and CpG oligodeoxynucleotides for allergen immunotherapy

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