Prevention and treatment of natural products from Traditional Chinese Medicine in depression: Potential targets and mechanisms of action

He, Ming-Chao; Feng, Rui; Wang, Jing; Xia, Shihui; Wang, Yongjun; Zhang, Yan

doi:10.3389/fnagi.2022.950143

Cited by 10 publications

(5 citation statements)

References 59 publications

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“…In contrast, in a college student population, Qi-stagnation and balanced constitutions were significantly associated with depression ( Yap et al, 2021 ), which is similar to our findings. For depression and other emotion problems, herbal formulas have also been developed in TCM, and these formulas target the BDNF-TrkB, MAPK pathway, etc., ( He et al, 2022 ). Our study suggests that patients with SSc who have Qi-deficiency and Yang-deficiency constitutions may need psychological and emotional support.…”

Section: Discussionmentioning

confidence: 99%

Care patterns and Traditional Chinese Medicine constitution as factors of depression and anxiety in patients with systemic sclerosis: A cross-sectional study during the COVID-19 pandemic

Kong

Chen²,

Dai³

et al. 2023

Front. Integr. Neurosci.

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ObjectiveCare patterns and Traditional Chinese Medicine (TCM) constitution affects the emotion and health of patients with systemic sclerosis (SSc) while the prevalence of COVID-19 may aggravate such patients’ emotion and health. We investigated the depression and anxiety levels of patients with SSc during the pandemic to identify the correlation between care patterns, TCM constitution, and patients’ emotion.Materials and methodsThis was a cross-sectional study. Patients with SSc and healthy individuals were surveyed using the patient health questionnaire-9, generalized anxiety disorder-7, and constitution in Chinese medicine questionnaire and a modified care pattern questionnaire. Factors correlated with depression and anxiety were screened using univariate and multivariate logistic regression analyses.ResultsA total of 273 patients with SSc and 111 healthy individuals were included in the analysis. The proportion of patients with SSc who were depressed was 74.36%, who had anxiety was 51.65%, and who experienced disease progression during the pandemic was 36.99%. The proportion of income reduction in the online group (56.19%) was higher than that in the hospital group (33.33%) (P = 0.001). Qi-deficiency [adjusted odds ratio (OR) = 2.250] and Qi-stagnation (adjusted OR = 3.824) constitutions were significantly associated with depression. Remote work during the outbreak (adjusted OR = 1.920), decrease in income (adjusted OR = 3.556), and disease progression (P = 0.030) were associated with the occurrence of depression.ConclusionChinese patients with SSc have a high prevalence of depression and anxiety. The COVID-19 pandemic has changed the care patterns of Chinese patients with SSc, and work, income, disease progression, and change of medications were correlates of depression or anxiety in patients with SSc. Qi-stagnation and Qi-deficiency constitutions were associated with depression, and Qi-stagnation constitution was associated with anxiety in patients with SSc.Trial registrationhttp://www.chictr.org.cn/showproj.aspx?proj=62301, identifier ChiCTR2000038796.

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Section: Discussionmentioning

confidence: 99%

Care patterns and Traditional Chinese Medicine constitution as factors of depression and anxiety in patients with systemic sclerosis: A cross-sectional study during the COVID-19 pandemic

Kong

Chen²,

Dai³

et al. 2023

Front. Integr. Neurosci.

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“…They play an irreplaceable role in clinical practice. 8,9 Yadanzi (Brucea Fructus) is the dried mature fruit of Brucea javanica (L.) Merr, a plant belonging to the Simaroubaceae family. It possesses functions such as heat-clearing, detoxification, antimalarial, and antidiarrheal effects.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, most of them have low toxicity and high safety and possess a broad potential market. They play an irreplaceable role in clinical practice. , …”

Section: Introductionmentioning

confidence: 99%

Study on the Mechanism of Yadanzi Oil in Treating Lung Cancer Based on Network Pharmacology and Molecular Docking Technology

Liu,

Shen,

et al. 2024

ACS Omega

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Brucea javanica oil emulsion (BJOE) is a compound Chinese medicine used for treating various cancers, such as lung cancer. However, the exact mechanism of its antilung cancer active ingredient remains unclear. This study aims to explore and validate the effective active ingredients and mechanism of action of BJOE in the treatment of lung cancer through network pharmacology, molecular docking technology, and cell experiments. The results showed that there were 13 active ingredients, 136 target genes, and 42 disease target-coexpressed genes in BJOE. The molecular docking results indicated that the main active components of the oil emulsion, YD1 (β-sitosterol), YD2 (luteolin), and YD3 (bruceitol), could stably bind to TP53 and MAPK1. Furthermore, the commercially available β-sitosterol luteolin was used as a representative compound to conduct cell experiments to verify its anticancer activity and mechanism. It was found that luteolin can inhibit the proliferation better than β-sitosterol and the activity of lung cancer cells by regulating the expression of related proteins through the P53/MAPK1 signaling pathway. This study combines network pharmacology prediction with experiments to demonstrate the "multicomponent, multitarget, multipathway" approach of B. javanica oil emulsion in treating lung cancer.

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“…Traditional Chinese medicine (TCM) profits from the flexible utilization of the concepts of holistic view and diagnosis and treatment in clinical, plays a role in the treatment of multiple diseases, especially in the fight against COVID-19, which has shown the world the great potential of TCM ( Lyu et al, 2021 ; Chen et al, 2022 ). In recent years, the antidepressant effects of herbal formulas and individual components have been gradually confirmed ( Li et al, 2020 ; He et al, 2022 ). For instance, Lu et al found that the methanol extract, ethanol extract, aqueous extract, and its volatile oil of Rhizoma Cyperi have antidepressant activity ( Lu et al, 2022 ); muscone may alleviate lipopolysaccharide (LPS)-induced depression-like behaviors through TLR/MyD88 and TLR4/NLRP3 pathways ( He et al, 2020 ); Lily Bulb and Rehmannia decoction can improve depression by reducing MAO activity, increasing monoamine neurotransmitter levels and regulating the hypothalamic-pituitary-adrenal (HPA) axis dysfunction ( Chi et al, 2019 ; Zhang et al, 2021 ), a meta-analysis showed that chaihu-jia-longgu-muli-tang can ameliorate the depressive manifestations of the patients via suppressing inflammation ( Zhao et al, 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Research progress on antidepressant effects and mechanisms of berberine

Gao,

Nie,

Wang

et al. 2024

Front. Pharmacol.

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Depression, a global health problem with growing prevalence, brings serious impacts on the daily life of patients. However, the antidepressants currently used in clinical are not perfectly effective, which greatly reduces the compliance of patients. Berberine is a natural quaternary alkaloid which has been shown to have a variety of pharmacological effects, such as hypoglycemic, lipid-regulation, anti-cancer, antibacterial, anti-oxidation, anti-inflammatory, and antidepressant. This review summarizes the evidence of pharmacological applications of berberine in treating depression and elucidates the mechanisms of berberine regulating neurotransmitter levels, promoting the regeneration of hippocampal neurons, improving hypothalamic-pituitary-adrenal axis dysfunction, anti-oxidative stress, and suppressing inflammatory status in order to provide a reference for further research and clinical application of berberine.

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Prevention and treatment of natural products from Traditional Chinese Medicine in depression: Potential targets and mechanisms of action

Cited by 10 publications

References 59 publications

Care patterns and Traditional Chinese Medicine constitution as factors of depression and anxiety in patients with systemic sclerosis: A cross-sectional study during the COVID-19 pandemic

Care patterns and Traditional Chinese Medicine constitution as factors of depression and anxiety in patients with systemic sclerosis: A cross-sectional study during the COVID-19 pandemic

Study on the Mechanism of Yadanzi Oil in Treating Lung Cancer Based on Network Pharmacology and Molecular Docking Technology

Research progress on antidepressant effects and mechanisms of berberine

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