Understanding and embracing diversity in education necessitates systematic and systemic approaches to ensure high standards and expectations for all learners. This special topic focuses on exploring inclusive practices within one such systemic educational approach designed to address students' social, emotional, behavioral, and learning needs-multitiered systems of support (MTSS). The roots of this systemic approach in the U.S. education system stem from the intersection of public health and education prevention-based models with the goal of improving outcomes for all learners. Specifically, MTSS is a teambased framework characterized by universal screening, multiple tiers of intervention, progress monitoring, and data-based decision making (e.g., Batsche, 2014; McIntosh & Goodman, 2016). MTSS typically includes the following three tiers of increasingly intensive intervention: Tier I universal supports for all students, Tier II targeted supports for students who may need additional intervention, and Tier III intensive support for students who need additional and more individualized intervention. The motivation for this special topic on MTSS grew from a technical working group (TWG) meeting held by the U.S.