Prevention and Treatment of Side Effects and Complications of Cutaneous Laser Resurfacing

Ts, Alster; Lupton,

doi:10.1097/00006534-200201000-00048

Cited by 102 publications

(4 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…21 , 22 , 23 , 24 However, subjects report recovery time following this treatment tends to be lengthy (at least 1 week or more) and side effects are severe (pain, persistent erythema, edema, infection, postinflammatory hyperpigmentation, and hypopigmentation). 25 , 26 This has led to the development of technologies with a more favorable profile, such as FRF. FRF devices have been proven to decrease the propensity for postinflammatory hyperpigmentation and the aforementioned problems of ablative lasers, all while achieving a similar level of acne scar reduction.…”

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of fractional radiofrequency for the treatment and reduction of acne scarring: A prospective study

Eubanks

Solomon

2021

Lasers Surg Med

View full text Add to dashboard Cite

Objectives: Skin rejuvenation with radiofrequency has been a widely used treatment modality for the safe and efficient remodeling of the dermis and revision of textural irregularities, achieved with minimal downtime. The efficacy of fractional radiofrequency (FRF) specifically for acne scarring has not been widely established. The objective of this clinical trial was to establish the efficacy and safety of FRF for moderate to severe acne scarring in a wide range of Fitzpatrick skin types using two different applicator tips to deliver energy to the skin (80-pin of up to 124 mJ/pin and 160-pin of up to 62 mJ/pin). Methods: Enrolled subjects received a series of three FRF treatments to the full face, each 4 weeks apart. A visual analog scale was utilized to assess pain of the treatment. Subject satisfaction questionnaires were completed at follow-up visits at 6 and 12 weeks post final treatment. Photographs were graded for change by three blinded evaluators using the Global Aesthetic Improvement Scale (GAIS). Results: Image sets of 23 enrolled subjects were assessed by blinded evaluation, showing a statistically significant improvement (p = 0.009) from the baseline visit to the 12-week follow-up on the GAIS for acne scarring. Subject satisfaction was high with subjects giving an average satisfaction score of 3.27 ("satisfied") out of 4. Pain was "mild" as treatments were rated an average of 2.15 on a 10-point visual analog scale. The GAIS score of the 80-pin tip improved patients' acne scars treated with that applicator by 1.06 points and 0.85 for the 160-pin tip. Ninety-five percent (95.5%) of subjects reported either a mild, moderate, or significant improvement to their treatment area. Ninety-one percent of subjects reported that they would recommend the treatment to a friend. Conclusion: FRF produced a statistically significant improvement in acne scarring when assessed by independent blinded evaluators. No serious adverse events resulted from treatment by either applicator tip. Treatment pain was low and tolerable among subjects of all Fitzpatrick skin types. Subjects had high levels of satisfaction with the results.

show abstract

Section: Discussionmentioning

confidence: 99%

Safety and efficacy of fractional radiofrequency for the treatment and reduction of acne scarring: A prospective study

Eubanks

Solomon

2021

Lasers Surg Med

View full text Add to dashboard Cite

show abstract

“…In the event of hypertrophic scar formation, common mitigation measures include early treatment with topical steroid cream, intralesional steroid and/or 5‐fluorouracil injections, and laser treatment of hypervascular scar tissue. 15 Another mitigation approach that remains under investigation involves the use of laser (ablative fractional) assisted topical drug delivery to enable both limited debulking of hypertrophic scar tissue and delivery of steroid and/or antimetabolite drugs to the remaining hypertrophic scar tissue. 16 Subjects with hypertrophic scarring in this study were treated with topical and/or intralesional steroids, intralesional 5‐fluorouracil, and vascular laser therapy (532 nm/1064 nm) with resolution in two of eight subjects by the 180‐day posttreatment visit (e.g., Figure 5 ); the remaining six AEs are responding to treatment and are expected to resolve with acceptable outcomes.…”

Section: Discussionmentioning

confidence: 99%

High energy, double pass helium plasma dermal resurfacing: A prospective, multicenter, single‐arm clinical study

Holcomb¹,

Doolabh²,

Lin

et al. 2022

Lasers Surg Med

View full text Add to dashboard Cite

Background: A previous multi-center clinical study of low energy (20% power), single-pass helium plasma dermal resurfacing (HPDR) showed positive results but did not fully reveal the true potential of this novel technology. A second multi-center clinical study, reported herein, was therefore undertaken to evaluate efficacy and safety of high energy (40%), double pass HPDR for treatment of facial rhytids (ClinicalTrials.gov Identifier: NCT04185909). Methods: Fifty-five eligible subjects seeking improvement in facial rhytids were enrolled for study at one of four investigational sites. All subjects underwent fullface HPDR treatment. The forehead, nose, cheeks, and peri-oral treatment zones were treated at 40% power with two passes whereas the peri-orbital and jawline/ mandibular zones were treated at 20% power (up to 40% for jawline/mandibular zone) and one or two passes. Photographic images of the face were captured using the VISIA-CR system. Three-month posttreatment Fitzpatrick Wrinkle and Elastosis Scale (FWS) scores were compared to baseline scores as determined by blinded independent photographic reviewers (IPRs) and study investigators.Results: Blinded IPRs and study investigators observed a ≥1-point FWS improvement in 100% of subjects with mean change in IPR FWS from baseline to the 90-day visit of −3.6 (±1.2). 96.4% of subjects indicated "improvement" in appearance at the 90-day visit utilizing the modified Global Aesthetic Improvement Scale. Evaluation of VISIA-CR data revealed statistically significant improvements in wrinkles, brown spots, and pore counts. Overall, 269 Adverse Events in 55 subjects were reported; most were mild-moderate in severity (99.3%), anticipated (86.2%), and of relatively short duration with most having resolved within 30 days (60.6%) of treatment. Conclusion: Treatment of facial rhytids with high energy, double pass HPDR as detailed herein enables a marked improvement in FWS that parallels or surpasses competing technologies. VISIA-CR analysis demonstrates additional improvements in skin quality with statistically significant quantitative improvements in brown spots and enlarged pores as well as wrinkles. Effective rhytid effacement combines with high subject satisfaction and few unanticipated adverse events for a reasonable benefit-risk ratio.

show abstract

“… 147 Infections are relatively uncommon, but patients with a history of herpes labialis should receive prophylactic oral antiviral therapy to reduce the incidence of latent herpes reactivation. 151 , 152 Postinflammatory hyperpigmentation occurs not infrequently, particularly in patients with darker skin tones or after aggressive laser treatment. 153 Delayed hypopigmentation is far less common – typically observed several months (>6 months) after treatment 147 and develops more frequently with CO 2 laser ablation than with Er:YAG.…”

Section: Ablative Laser Resurfacingmentioning

confidence: 99%

The role of lasers and intense pulsed light technology in dermatology

Husain¹,

Alster²

2016

CCID

View full text Add to dashboard Cite

The role of light-based technologies in dermatology has expanded dramatically in recent years. Lasers and intense pulsed light have been used to safely and effectively treat a diverse array of cutaneous conditions, including vascular and pigmented lesions, tattoos, scars, and undesired hair, while also providing extensive therapeutic options for cosmetic rejuvenation and other dermatologic conditions. Dermatologic laser procedures are becoming increasingly popular worldwide, and demand for them has fueled new innovations and clinical applications. These systems continue to evolve and provide enhanced therapeutic outcomes with improved safety profiles. This review highlights the important roles and varied clinical applications that lasers and intense pulsed light play in the dermatologic practice.

show abstract

Prevention and Treatment of Side Effects and Complications of Cutaneous Laser Resurfacing

Cited by 102 publications

References 29 publications

Safety and efficacy of fractional radiofrequency for the treatment and reduction of acne scarring: A prospective study

Safety and efficacy of fractional radiofrequency for the treatment and reduction of acne scarring: A prospective study

High energy, double pass helium plasma dermal resurfacing: A prospective, multicenter, single‐arm clinical study

The role of lasers and intense pulsed light technology in dermatology

Contact Info

Product

Resources

About