Prevention and Treatment of Transplant Rejection in Keratoplasty

Pleyer, Uwe; Maier, Anna-Karina B.

doi:10.1007/978-3-642-54350-0_6

Cited by 1 publication

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“…Nebenwirkungen ist die Umstellung auf eine veränderte Darreichungsform mit einem verkapselten Wirkstoff ("enteric coating") (EC-MPS) möglich [40].…”

Section: Mycophenolsäure (Mps)unclassified

Das okuläre vernarbende Pemphigoid - aktuelle Aspekte zu Klinik und Therapie einer problematischen Erkrankung

Rübsam

Klein

Pleyer

2013

Klin Monatsbl Augenheilkd

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The ocular cicatricial pemphigoid (OCP) belongs to a family of chronically progressive autoimmune disorders, predominantly affecting mucous membranes (mucous membrane pemphigoids). It is an immunopathologically heterogeneous group of disorders with variable phenotypes that share the unique feature of a subepidermal blistering, through disruption of the adhesion between epidermis and dermis. A key feature is the chronically active inflammation with consecutive fibrosis, leading to a partial or complete loss of function of the affected organ. The ocular disease as a chronic cicatrising conjunctivitis is a common manifestation of the mucous membrane pemphigoid. The identification of the subtle pathology and the prompt initiation of an appropriate therapy are of pivotal importance. One purpose is to prevent further vision loss due to extensive corneal scarring and life-threatening systemic complications, such as the formation of oesophageal or tracheal strictures. So far there are no prospective, randomised studies, regarding the therapy guidelines with an evidence level more than III. The autoimmune nature of the disease implies that systemic immunosuppression is the only effective treatment option, most notably in extended stages. The aim of our study is to give a guideline for a stage adjusted therapy with conventional immunosuppressants and to give a perspective for alternative therapies, especially for recalcitrant disease.

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“…Nebenwirkungen ist die Umstellung auf eine veränderte Darreichungsform mit einem verkapselten Wirkstoff ("enteric coating") (EC-MPS) möglich [40].…”

Section: Mycophenolsäure (Mps)unclassified

Das okuläre vernarbende Pemphigoid - aktuelle Aspekte zu Klinik und Therapie einer problematischen Erkrankung

Rübsam

Klein

Pleyer

2013

Klin Monatsbl Augenheilkd

View full text Add to dashboard Cite

show abstract

Prevention and Treatment of Transplant Rejection in Keratoplasty

Cited by 1 publication

References 100 publications

Das okuläre vernarbende Pemphigoid - aktuelle Aspekte zu Klinik und Therapie einer problematischen Erkrankung

Das okuläre vernarbende Pemphigoid - aktuelle Aspekte zu Klinik und Therapie einer problematischen Erkrankung

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