Prevention and treatment of viral and bacterial diseases of young horses

Neustroev, M. P.; Petrova, S. G.; Elbiadova, E. I.; Попов, А. А.

doi:10.18411/lj-10-2018-167

Cited by 2 publications

(9 citation statements)

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“…According to the veterinary service of the Republic of Sakha (Yakutia) and our own research in 2002-2020 circulation of the rhinopneumonia virus was noted in 99 points of 16 districts of the republic, and the incidence of strangles of young horses is recorded annually and reaches 62.7% of the total number of young horses [1].…”

Section: Introductionmentioning

confidence: 92%

“…In the Russian Federation, in the Republic of Sakha (Yakutia), special attention should be paid to diseases of young horses, since these diseases cause enormous economic damage to herd horse breeding, which consists of a lack of offspring, culling of horses, loss of reproductive ability of mares, death of animals, as well as costs of medical and preventive measures. The studies of foreign authors and our previous studies have established that young animals up to one-year-old can get sick with several infectious diseases at the same time [1,2]. The most common diseases among young horses are rhinopneumonia and strangles of horses.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, in recent years, the rhinopneumonia virus has been detected in Israel [7], Australia, China and Ireland by a number of authors from different continents [8,9,10]. Strangles of horses is most common in Novosibirsk, Altai, Irkutsk regions, Krasnoyarsk and Altai territories [11], the Republics of Tyva [12], Khakassia, Sakha (Yakutia) [1] of the Russian Federation, as well as in Kazakhstan [13], Mongolia [14], Kyrgyzstan [15], the Netherlands [16], the Arab Republic of Egypt [17], Korea [18], Brazil [19].…”

Section: Introductionmentioning

confidence: 99%

“…In herd horse breeding, inactivated single-use vaccines have found wider use. Vaccines with double and triple use are not technologically suitable for prophylactic immunization of horses in the Far North [1,20]. In horse breeding farms of the Republic of Sakha (Yakutia), the use of vaccines with two and three injections is difficult due to natural and climatic conditions, since the second and third immunization of horses occurs in January-February.…”

Section: Introductionmentioning

confidence: 99%

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Preclinical tests of Vaccine against Rhinopneumonia and Strangles of young horses

2022

pnr

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Efficacy and safety of the combined vaccine against rhinopneumonia and strangles of horses were evaluated on outbred mice and rabbits. Acute toxicity, pyrogenicity and immunogenicity were carried out in accordance with the methods regulated by the Rosselkhoznadzor of the Russian FederationThe absence of toxicity was established with a single intragastric administration of the vaccine to white mice. An analysis of the dynamics of the body weight of white mice revealed an increase in both the control and experimental groups. Thus, the increase was 9.2% in the experimental group that received the vaccine preparation, and in the control group -5.05%. Therefore, in mice treated intragastrically with the vaccine preparation, active growth is observed in comparison with the control. The difference was 4.15%. The disease and mortality among vaccinated mice were not noted, which indicates its harmlessness and safety.The test of the vaccine preparation on rabbits showed its non-pyrogenicity. In the third hour after the administration of the drug, the temperature of rabbits in the control group rose by 0.2ºC, and in the experimental group by 0.4ºC. However, during a clinical examination of the experimental animals of both groups, signs of illness and changes in the general condition were not recorded. Thus, the studied vaccine preparation was considered non-pyrogenic, since after its administration to rabbits, a slight short-term increase in body temperature is observed in animals of both groups, in which the general condition of the animals remains favorable.The immunogenicity of the viral component of the associated vaccine against rhinopneumonia and strangles of horses was studied on outbred mice. Studies have shown sufficient immunogenicity (75%) when the vaccine is administered subcutaneously at a dose of 0.3 cm3 twice with an interval of 14 days, followed by control infection with an adapted strain of equine rhinopneumonia virus at a dose of 0.02x6.0 lgTCD50/ml intracerebral.Evaluation of the immunogenic activity of the strangles composition of the vaccine was carried out in experiments with a single immunization of white outbred mice, followed by infection with a virulent culture of the strangles streptococcus Streptococcus equi "H-5/1" at a dose of LD50 (200 thousand microbial bodies per 1 cm3). The bacterial component protects against the causative agent of strangles by 80% of the number of infected animals.The aim of our research was to study the efficacy and safety of the combined vaccine against rhinopneumonia and strangles of horses in laboratory conditions. This paper presents the results of preclinical studies on laboratory animals. The absence of acute toxicity, allergenic, pyrogenic properties and the safety of using the associated vaccine against rhinopneumonia and strangles of horses on laboratory animals have been proven.

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Section: Introductionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preclinical tests of Vaccine against Rhinopneumonia and Strangles of young horses

2022

pnr

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“…During the long autumn/winter period, the spread of viral diseases such as influenza and rhinopneumonia among breeds of horses is notable. Not surprisingly, a decrease in the level of immunobiological reactivity of foals and mares was observed and could be correlated with an increase of stress factors and viral infections [32][33][34]. Both researchers presented preliminary results on the complementary use of immunomodulators and inactivated vaccines to improve the protection of livestock [work in progress, unpublished results].…”

Section: Preventive Measures Immunomodulationmentioning

confidence: 99%

Symposium report: emerging threats for human health – impact of socioeconomic and climate change on zoonotic diseases in the Republic of Sakha (Yakutia), Russia

Huber

Potapova

Федоров

et al. 2020

International Journal of Circumpolar Health

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Population growth, socio-cultural and economic changes as well as technological progress have an immediate impact on the environment and human health in particular. Our steadily rising needs of resources increase the pressure on the environment and narrow down untainted habitats for plants and wild animals. Balance and resilience of ecosystems are further threatened by climate change, as temperature and seasonal shifts increase the pressure for all species to find successful survival strategies. Arctic and subarctic regions are especially vulnerable to climate change, as thawing of permafrost significantly transforms soil structures, vegetation and habitats. With rising temperature, the risk of zoonotic diseases in the Republic of Sakha (Yakutia) has also increased. As vegetation periods prolong and habitats broaden, zoonotic pathogens and their vectors find more favourable living conditions. Moreover, permafrost degradation may expose historic burial grounds and allow for reviving the vectors of deadly infections from the past. To assess the current state of knowledge and emerging risks in the light of the "One Health" concept, a German-Russian Symposium took place on 13 August 2018 in Yakutsk, Russian Federation. This symposium report presents the main findings generated from presentations and discussions.

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Prevention and treatment of viral and bacterial diseases of young horses

Cited by 2 publications

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Preclinical tests of Vaccine against Rhinopneumonia and Strangles of young horses

Preclinical tests of Vaccine against Rhinopneumonia and Strangles of young horses

Symposium report: emerging threats for human health – impact of socioeconomic and climate change on zoonotic diseases in the Republic of Sakha (Yakutia), Russia

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