Take-Home Messages• On average one in three patients do not return to work after knee arthroplasty • Patients return to work around 12 weeks post-surgery, although large differences exist between patients and full return to work may take more than 6 months. • The cause for not returning to work is multifactorial, but known prognostic factors are preoperative sick leave of more than 2 weeks, female sex, high body mass index (BMI), patient-reported work-relatedness of knee symptoms, and physically demanding jobs. Age and Knee Injury and Osteoarthritis Outcome Scores (KOOS) were not associated with no return to work. • At present, no studies are available that evaluated the effect of exercise-based rehabilitation, active referral to an occupational physician or therapist, or other forms of multidisciplinary care for knee arthroplasty on return to work. • Promising interventions for return to work are better expectation management by setting preoperative patient-centered realistic work-related activity goals, preoperative referral to an occupational physician or therapist to actively address prognostic factors hindering return to work, and the use of personalized e/mHealth including activity trackers to support KA patients on a daily basis in return to work.