Prevention by Lactic Acid Bacteria of the Oxidation of Human LDL

Terahara, Masaki; Kurama, Takeshi; Takemoto, Naoki

doi:10.1271/bbb.65.1864

Cited by 28 publications

(14 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6) Since Shaper et al 7) and Mann 8) observed that the consumption of large quantities of fermented milk containing a wild Lactobacillus by the Samburu and Masai tribes of Africa resulted in reductions in serum cholesterol levels, the ingestion of probiotic lactic acid bacteria has been pursued as a more natural way to decrease human cholesterol levels. It has been also reported that probiotic bacteria or their extracts exert antioxidative effects in vitro, [9][10][11] and exhibit a protective effect against hemolysis in vitamin E-deficient rats.…”

Section: )mentioning

confidence: 98%

Effects of Bacillus polyfermenticus SCD on Lipid and Antioxidant Metabolisms in Rats Fed a High-Fat and High-Cholesterol Diet

Paik

Park

2005

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Bacillus polyfermenticus SCD, commonly referred to as Bispan strain, is used as a host in bioindustry and has been shown to have several human health benefits. In a recent in vitro study, we discovered that B. polyfermenticus SCD exerts cholesterol-lowering and antioxidant effects. Here, we evaluate the effects of B. polyfermenticus SCD on the lipid and antioxidant metabolisms of hypercholesterolemic rats. Twenty male Sprague-Dawley rats were divided into two groups after a 1-week adaptation period and were fed for 6 weeks on either a high fat-high cholesterol diet, or a high fat-high cholesterol diet supplemented with B. polyfermenticus SCD (3.1؋10 6 cfu/d). B. polyfermenticus SCD significantly reduced plasma low-density-lipoprotein cholesterol, hepatic total cholesterol, and triglycerides, while increasing the fecal excretion rates of total cholesterol and triglycerides. In addition, B. polyfermenticus SCD might reduce the risk of atherosclerosis, as the ratio of high-density-lipoprotein cholesterol to total cholesterol was significantly higher than in the control group. B. polyfermenticus SCD led to an increase in total radical trapping antioxidant potential (TRAP) and a decrease in conjugated dienes in plasma. The erythrocytic glutathione peroxidase (GSH-Px) activity in the B. polyfermenticus group was significantly lower than that in the control group. Plasma TRAP levels exhibited a highly significant negative correlation with hepatic total cholesterol and a marginally significant negative correlation with total plasma cholesterol, while a significant positive correlation was detected between fecal total cholesterol and plasma TRAP. These results suggest that B. polyfermenticus SCD exerts significant health benefits through the modulation of physiologic functions including a variety of atherogenic lipid profiles and antioxidants in hypercholesterolemia.

show abstract

Section: )mentioning

confidence: 98%

Effects of Bacillus polyfermenticus SCD on Lipid and Antioxidant Metabolisms in Rats Fed a High-Fat and High-Cholesterol Diet

Paik

Park

2005

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…These findings were later confirmed (Perdigo´n, Vintin˜i, Alvarez, Medina, & Medici, 1999) when L. delbrueckii was able to induce an increase of IgA + cells entering the IgA cycle. In addition, the antioxidative activity of L. delbrueckii was demonstrated under in vitro conditions (Saide & Gilliland, 2005), as extracts of bacterial cells inhibited oxidation of erythrocyte membranes and low-density lipoproteins (LDL) (Terehara, Kurama, & Takemoto, 2001). These bacteria could be a source of dietary antioxidants, providing a further health or nutritional benefit.…”

Section: Introductionmentioning

confidence: 99%

Probiotic potential of Lactobacillus delbrueckii strains and their phage resistant mutants

Guglielmotti

Marcó

Golowczyc

et al. 2007

International Dairy Journal

View full text Add to dashboard Cite

“…The utilization of lactic acid bacteria (LAB) exerting antioxidative activity is a fascinating subject of study in this respect. Although some reports have documented the antioxidative effects of LAB, [1][2][3] there are no reports identifying the antioxidants produced by LAB. The aim of this study was to isolate and identify the antioxidants in cultures of LAB.…”

mentioning

confidence: 99%