Prevention Conference V

Smith, Sidney C.; Amsterdam, Ezra A.; Balady, Gary J.; Bonow, Robert O.; Fletcher, Gerald F.; Froelicher, Victor; Heath, Gregory W.; Limacher, Marian C.; Maddahi, Jamshid; Pryor, David; Redberg, Rita F.; Roccella, Edward J.; Ryan, Thomas J.; Smaha, Lynn A.; Wenger, Nanette K.

doi:10.1161/01.cir.101.1.e12

Cited by 70 publications

(24 citation statements)

References 28 publications

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“…Most studies of the accuracy of exercise screening tests for CAD in asymptomatic populations have concluded that the exercise test, with or without imaging, yielded many falsepositives. 3,5,12 In subjects with ischemia in the present study, we do not believe that these results represent false-positive tests. The location of the defect most often matched the artery with the most severe stenosis, even when the stenosis was mild.…”

Section: Blumenthal Et Al Occult Coronary Disease Detection In Familimentioning

confidence: 46%

“…2 In asymptomatic individuals, however, the degree to which noninvasive test abnormalities represent obstructive CAD remains unknown, although in the general population, it is thought to be poor. 3 In high-risk asymptomatic individuals, noninvasive tests may be more accurate. 3 Noninvasive testing may add information to risk factor screening in high-risk populations with a high a priori probability of disease.…”

mentioning

confidence: 99%

“…3 In high-risk asymptomatic individuals, noninvasive tests may be more accurate. 3 Noninvasive testing may add information to risk factor screening in high-risk populations with a high a priori probability of disease. This could result in more aggressive guidelines for preventive therapies.…”

mentioning

confidence: 99%

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Detecting Occult Coronary Disease in a High-Risk Asymptomatic Population

et al. 2003

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Background-Exercise stress testing alone or with perfusion imaging is the standard screening method to determine the presence of obstructive coronary artery disease (CAD) in people with chest pain. In asymptomatic individuals with a family history of premature CAD, it is unclear whether abnormalities on these functional exercise tests represent significant coronary disease. Methods and Results-An abnormal exercise test, thallium scan, or both occurred in 153 (21%) of 734 asymptomatic siblings of persons with documented CAD, of whom 105 underwent coronary angiography with quantitative analysis of stenosis severity. Overall, 95% had coronary atherosclerosis, but only 39% had 1 or more stenoses with Ն50% narrowing. Of 30 siblings in whom the exercise test and perfusion scan were both abnormal, 70% had Ն50% stenoses. The mean stenosis in arteries that fed perfusion defects was only 43Ϯ31%, and 68% of such stenoses were Ͻ50%. However, in 71% of all defects, the location matched arteries with the most severe stenoses. Conclusions-In

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Section: Blumenthal Et Al Occult Coronary Disease Detection In Familimentioning

confidence: 46%

mentioning

confidence: 99%

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Detecting Occult Coronary Disease in a High-Risk Asymptomatic Population

et al. 2003

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“…For this reason, patients need to be monitored closely, and inappropriate decreases or increases in blood pressure must be detected and treated. Guidelines on the use of these tests 52 as well as on the use of coronary angiography have been published. 53 The current ACC/AHA practice guideline on exercise testing identifies exercise testing as a Class IIb recommendation for asymptomatic individuals with multiple risk factors as a guide to risk-reduction therapy, as well as for men Ͼ45 years of age and postmenopausal women Ͼ55 who are at high risk for CHD because of other diseases.…”

Section: Testing For Unrecognized Chdmentioning

confidence: 99%

Coronary Risk Evaluation in Patients With Transient Ischemic Attack and Ischemic Stroke

Adams¹,

Chimowitz²,

Alpert³

et al. 2003

Circulation

226

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Stroke and myocardial infarction (MI) share common risk factors and pathological mechanisms, and coronary artery disease (CHD) is an important cause of death in patients with cerebrovascular disease. This Scientific Statement addresses issues in management of the relatively healthy patient with brain ischemia (a transient ischemic attack [TIA] or an ischemic stroke) who does not have recognized CHD but often has risk factors in addition to having had a TIA or stroke that indicate an increased likelihood of disability or death from cardiac disease in the future. This Statement should not be confused with the official American College of Cardiology (ACC)/American Heart Association (AHA) practice guidelines. The reader is referred to the ACC/AHA guidelines for management of recognized and symptomatic CHD 1 and the American College of Chest Physicians (ACCP) 2 and American Stroke Association (ASA) 3-5 guidelines for evaluation of cardiac causes of TIA and stroke, which are important related but separate issues.

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“…Signs that can be detected using radiofrequency can be employed to measure the IMC of the common carotid artery, which is able to detect early variations in IMT that may be related to CVDs, and can also be used to monitor the success of treatment and reduction of risk factors for CVDs. 33 The American Heart Association recommends measuring IMT to assess cardiovascular risk 34 …”

Section: Markers Of Atherosclerotic Diseasementioning

confidence: 99%

Periodontal disease and atherosclerosis

et al. 2014

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Atherosclerotic disease (AD) is one of the most important causes of morbidity and mortality in the world. It expresses inflammatory markers such as C-reactive protein (CRP) and can provoke arterial wall thickening, which can be evaluated using Doppler ultrasound. Risk factors associated with AD include diabetes mellitus, systemic arterial hypertension, dyslipidemia and smoking. More recently, periodontal disease (PD) has been identified as a factor related to AD. Periodontal disease has a high prevalence in the global population and the inflammatory process and bacterial activity at the periodontium appear to increase the risk of AD. Encouraging good oral hygiene can reduce expression of inflammatory markers of AD. A review of literature on PD, AD and inflammatory markers and the interrelationships between the two diseases was conducted using data published in articles indexed on the PUBMED, SCIELO and BIREME databases.Keywords: periodontal disease; atherosclerosis; carotid intima-media thickness. ResumoA doença aterosclerótica (DA) constitui uma das principais causas de morbimortalidade no mundo. A sua expressão laboral pode ser através de marcadores inflamatórios, como a proteína C reativa (PCR) e/ou o espessamento da parede arterial, que pode ser analisado pela ultrassonografia com Doppler colorido. Os fatores de risco associados à DA são o diabetes mellitus, a hipertensão arterial sistêmica, a dislipidemia e o tabagismo. Mais recentemente, a doença periodontal (DP), que tem uma elevada prevalência na população mundial, tem sido considerada um fator relacionado ao desenvolvimento da DA, em que o processo inflamatório e a atividade bacteriana no periodonto parecem aumentar o risco para a DA. A motivação da higiene oral pode diminuir a expressão dos marcadores inflamatórios da DA. Com base em dados publicados em revistas eletrônicas e indexados pelos mecanismos de busca PUBMED, SCIELO e BIREME, foi realizada uma revisão de literatura sobre a DP e a DA, além dos marcadores inflamatórios expressos em ambas as doenças e suas possíveis inter-relações.

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Prevention Conference V

Cited by 70 publications

References 28 publications

Detecting Occult Coronary Disease in a High-Risk Asymptomatic Population

Detecting Occult Coronary Disease in a High-Risk Asymptomatic Population

Coronary Risk Evaluation in Patients With Transient Ischemic Attack and Ischemic Stroke

Periodontal disease and atherosclerosis

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