Prevention, Diagnosis, and Treatment of Cerebral Palsy in Near-term and Term Infants

Shankaran, Seetha

doi:10.1097/grf.0b013e3181870c35

Cited by 25 publications

(13 citation statements)

References 31 publications

(26 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It is caused by damage to the developing brain resulting in neurological and motor deficits. In adulthood mortality and morbidity from ischaemic heart disease, cerebrovascular disease, cancer and trauma are higher in people with cerebral palsy than in the general population (2). The underlying causes of the condition remain under debate and vary from medical mismanagement at birth to multifactor steps which form a series of causal pathways (3).…”

Section: Introductionmentioning

confidence: 99%

Association of cerebral palsy with consanguineous parents and other risk factors in a Palestinian population

Daher

El-Khairy

2014

East Mediterr Health J

View full text Add to dashboard Cite

This case-control study investigated risk factors for cerebral palsy in a Palestinian population. Cases were 107 children aged 1-15 years at a cerebral palsy referral centre in Jerusalem; controls were 233 children without cerebral palsy from West Bank outpatient clinics. Data were collected from medical records and a structured questionnaire to parents. In stepwise logistical regression, consanguinity and birth deficits in other family members were positively associated with cerebral palsy (OR = 4.62; 95% CI: 2.07-10.3 and OR = 12.7; 95% CI: 3.13-51.7 respectively), suggesting a possible genetic link. Other risk factors were: perinatal hypoxia (OR = 92.5; 95% CI: 24.5-350), low birth weight (OR = 4.98; 95% CI: 2.01-12.3), twin births (OR = 9.25; 95% CI: 1.29-66.8) and no prenatal medical care (OR = 5.22; 95% CI: 1.18-23.1). This first stepwise model of significant and modifiable risk factors in our population provides useful evidence for policy-makers.

show abstract

Section: Introductionmentioning

confidence: 99%

Association of cerebral palsy with consanguineous parents and other risk factors in a Palestinian population

Daher

El-Khairy

2014

East Mediterr Health J

View full text Add to dashboard Cite

show abstract

“…[1][2][3][4][5][6][7][8] Obtaining an objective measurement of intrapartum hypoxia has two primary goals. First, to increase understanding of its association with adverse neonatal outcomes and address primary prevention, 9,10 and second to be able to predict those neonates at risk for morbidity and mortality and to ensure appropriately focused interventions.…”

Section: Introductionmentioning

confidence: 99%

Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review

Allanson

Waqar

White

et al. 2016

BJOG

View full text Add to dashboard Cite

Background Umbilical cord lactate is one approach to measuring acidosis and intrapartum hypoxia, knowledge of which may be helpful for clinicians involved in the care of women and newborns.Objective To synthesise the evidence on accuracy of umbilical cord lactate in measuring acidosis and predicting poor neonatal outcome.Search strategy Studies published and unpublished between 1990 and 2014 from PubMed/Medline, EMBASE, Cochrane Central Register of Controlled Trials, and clinicaltrials.gov were assessed.Selection criteria Cross-sectional and randomised studies that assessed fetal acidosis (using lactate as the index test) with or without an assessment of neonatal outcome.Data collection and analysis Correlations between index and reference test(s) were recorded, as were the raw data to classify the predictive ability of umbilical lactate for neonatal outcomes. Metaanalysis of correlation was performed. We plotted estimates of the studies' observed sensitivities and specificities on Forest plots with 95% confidence intervals (CI). Where possible, we combined data using meta-analysis, applying the hierarchical summary receiver operating characteristics model and a bivariate model.Main results Twelve studies were included. Umbilical lactate correlated with pH [pooled effect size (ES) À0.650; 95% CI À0.663 to À0.637, P < 0.001], base excess (ES À0.710; 95% CI À0.721 to À0.699, P < 0.001), and Apgar scores at 5 minutes (ES 0.300; 95% 0.193-0.407, P < 0.001). Umbilical lactate had pooled sensitivity and specificity for predicting neonatal neurological outcome including hypoxic ischaemic encephalopathy of 69.7% (95% CI 23.8-94.4%) and 93% (95% CI 86.8-96.3%).Authors' conclusion Umbilical cord lactate is a clinically applicable, inexpensive and effective way to measure acidosis and is a tool that may be used in the assessment of neonatal outcome.

show abstract

“…In our study, the majority of patient samples especially MCP, have one or more of the following features: dysnoesia, dysarthria, visual perceptive dysfunction and hearing impairment. Spastic quadriplegia was often associated with cortical and subcortical white matter damage or extensive necrosis in the brain [27]. Based on these facts, we could see that CP, especially mixed CP, was more often caused by the cerebral injury.…”

mentioning

confidence: 72%

The association between GAD1 gene polymorphisms and cerebral palsy in Chinese infants

Lin

Zhu

et al. 2013

Cytol. Genet.

View full text Add to dashboard Cite

show abstract

Prevention, Diagnosis, and Treatment of Cerebral Palsy in Near-term and Term Infants

Cited by 25 publications

References 31 publications

Association of cerebral palsy with consanguineous parents and other risk factors in a Palestinian population

Association of cerebral palsy with consanguineous parents and other risk factors in a Palestinian population

Umbilical lactate as a measure of acidosis and predictor of neonatal risk: a systematic review

The association between GAD1 gene polymorphisms and cerebral palsy in Chinese infants

Contact Info

Product

Resources

About