Prévention et traitement des synéchies endo-utérines : revue de la littérature

Warembourg, Sophie; Huberlant, S.; Garric, Xavier; Leprince, S.; Tayrac, Renaud de; Letouzey, V.

doi:10.1016/j.jgyn.2014.10.014

Cited by 32 publications

(7 citation statements)

References 146 publications

(152 reference statements)

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“…Intrauterine adhesion (IUA) is a major cause of female secondary infertility [1]. The classical therapeutic approaches for infertile patients with IUA are hysteroscopic adhesiolysis, removing visible intrauterine adhesions.…”

Section: Introductionmentioning

confidence: 99%

Platelet-rich plasma improves therapeutic effects of menstrual blood-derived stromal cells in rat model of intrauterine adhesion

Zhang

Yuan

et al. 2019

Stem Cell Res Ther

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Background Intrauterine adhesion (IUA) is a major cause of female secondary infertility. We previously demonstrated that menstrual blood-derived stromal cell (MenSC) transplantation helped severe IUA patients have pregnancy and endometrium regeneration. We also initiated platelet-rich plasma (PRP) acted as a beneficial supplement in MenSC culturing and a potential endometrial receptivity regulator. Here, we investigated the therapeutic effect of combined transplantation of MenSCs with PRP in rat IUA models and the mechanisms of MenSCs in endometrium regeneration. Methods Rat IUA models were established by intrauterine mechanical injured. Nine days later, all rats were randomly assigned to four groups received different treatment: placebo, MenSC transplantation, PRP transplantation, and MenSCs + PRP transplantation. The traces of MenSCs were tracked with GFP label. Endometrial morphology and pathology, tissue proliferation, inflammation, pregnancy outcomes, and mechanism of MenSCs in the regeneration of endometrium were investigated. Results Notably, at days 9 and 18 post-treatment, MenSC transplantation significantly improved endometrial proliferation, angiogenesis, and morphology recovery and decreased collagen fibrosis and inflammation in the uterus. MenSCs had lesion chemotaxis, colonized around the endometrial glands. Gene expression of human-derived secretory protein IGF-1 , SDF-1 , and TSP-1 was detected in the uterus received MenSCs at day 18. The three treatments can all improve fertility in IUA rats. Moreover, gene expressions of cell proliferation, developmental processes, and other biological processes were induced in MenSC transplantation group. Hippo signaling pathway was the most significantly changed pathway, and the downstream factors CTGF, Wnt5a, and Gdf5 were significantly regulated in treatment groups. PRP enhanced these parameters through a synergistic effect. Conclusions In summary, MenSCs could effectively improve uterine proliferation, markedly accelerate endometrial damage repairment and promote fertility restoration in IUA rats, suggesting a paracrine restorative effect and Hippo signaling pathway stimulation. Our results indicate MenSCs, a valuable source of cells for transplantation in the treatment intrauterine adhesion. Combined with PRP, this cell therapy was more effective. Electronic supplementary material The online version of this article (10.1186/s13287-019-1155-7) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Platelet-rich plasma improves therapeutic effects of menstrual blood-derived stromal cells in rat model of intrauterine adhesion

Zhang

Yuan

et al. 2019

Stem Cell Res Ther

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“…Patients will frequently complain of menstrual irregularities that include amenorrhea or hypomenorrhea, but may also include dysmenorrhea due to retrograde menstruation [92]. IUA are also an important risk factor for infertility, miscarriage, premature rupture of membranes, caesarean section due to non-cephalic presentation, low birth weight and increased risk of admission to neonatal intensive care unit [93,94].…”

Section: Intrauterine Adhesionsmentioning

confidence: 99%

Operative Hysteroscopy Complications

Serranito¹

2023

Updates in Endoscopy

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Operative hysteroscopy is a minimally invasive gynaecological procedure and is considered the gold standard for the treatment of intracavitary uterine pathology. Over the last decades, with the development of new surgical instruments, the popularity of this technique has increased with gynaecologists across the world. However, this minimally invasive technique can be associated with rare but serious complications that can lead to severe morbidity and, if not treated adequately in some cases, ultimately lead to mortality. Any gynaecologist using this procedure should not only train in the operative technique but should also acquire knowledge on what type of complications may arise whilst performing an operative hysteroscopy. The following chapter explores the diagnosis of complications associated with the operative hysteroscopy and management options.

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“…The resulting obliteration of the uterine cavity can be partial or total (Asherman's syndrome) (1). It most commonly occurs after traumas to the basalis layer of the endometrium most frequently, after curettage, cesarean sections, post-partum hemorrhage, abdominal myomectomy, and/or hysteroscopic resections of myoma, polyp, or uterine septum (2, 3). More rarely, it may also occur secondarily to infection (such as genital tuberculosis, endometritis).…”

Section: Introductionmentioning

confidence: 99%

“…IUAs can be responsible of symptoms including, chronic abdominal pain, menstrual abnormalities, and/or cause obstetric consequences like miscarriages, premature rupture of membranes (PROM), premature delivery, or placenta accreta (2). Furthermore, IUA is one of the main cause of secondary infertility with an incidence of 1.7–7% seen when hysteroscopies are performed in infertile women (4).…”

Section: Introductionmentioning

confidence: 99%

Early Second-Look Hysteroscopy: Prevention and Treatment of Intrauterine Post-surgical Adhesions

et al. 2019

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Introduction: Intra-uterine adhesion (IUA) is one of the main causes of secondary infertility. The aim of this study was to evaluate the prevalence of IUA developing in women undergoing hysteroscopic resection for submucous myomas, polyps, and intrauterine synechiae and test the efficacy of second look hysteroscopy for diagnosing and treating post-surgical adhesions. Materials and Methods: We retrospectively collected data from reproductive age women who had a second look office hysteroscopy following hysteroscopic resection for myoma, polyp, or IUA at Foch hospital (Suresnes, France) between 2009 and 2017. Results: Six hundred and twenty two reproductive-age women underwent hysteroscopic resection for myoma, polyp, and/or IUA. Among them, 155 women had a second look hysteroscopy. In this group, 29/155 (18.7%) had IUA formation: 17/83 (20.5%) women who underwent hysteroscopic myomectomy, 5/46 (10.9%) women who underwent hysteroscopic polypectomy, and 7/26 (26.9%) women who underwent hysteroscopic lysis of adhesions. These IUA have been lysed by the office hysteroscopy procedure in 16/29 (55.2%) patients: 11/17 (64.7%), 2/5 (40%), and 3/7 (42.9%) in women who underwent hysteroscopic myomectomy, polypectomy and lysis of adhesion, respectively. Conclusion: IUA is a common complication of hysteroscopic surgery. Second look office hysteroscopy is an easy and effective procedure for diagnosing and removing newly formed IUA. It should be recommended for all women undergoing hysteroscopic resection for myomas, polyps, or IUA.

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Prévention et traitement des synéchies endo-utérines : revue de la littérature

Cited by 32 publications

References 146 publications

Platelet-rich plasma improves therapeutic effects of menstrual blood-derived stromal cells in rat model of intrauterine adhesion

Platelet-rich plasma improves therapeutic effects of menstrual blood-derived stromal cells in rat model of intrauterine adhesion

Operative Hysteroscopy Complications

Early Second-Look Hysteroscopy: Prevention and Treatment of Intrauterine Post-surgical Adhesions

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