Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model

Setozaki, Shuji; Minakata, Kenji; Masumoto, Hidetoshi; Hirao, Shigekazu; Yamazaki, Kazuhiro; Kuwahara, Koichiro; Ikeda, Tadashi; Sakata, Ryuzo

doi:10.1016/j.jvs.2016.06.003

Cited by 29 publications

(15 citation statements)

References 36 publications

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“…In previous studies, many dietary components or herbal extracts such as advanced glycation end products (AGEs), copper, green tea, vitamin D, β-carotene, vitamin B6, Calendula officinalis have been shown to regulate LOX activity [ 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 ]. AGEs are a group of reactive compounds formed by the Maillard reaction.…”

Section: Dietary Components Regulate Lox Activitymentioning

confidence: 99%

Lysyl Oxidase and the Tumor Microenvironment

Wang

Hsia

Shieh

2016

IJMS

137

102

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The lysyl oxidase (LOX) family of oxidases contains a group of extracellular copper-dependent enzymes that catalyze the cross-linking of collagen and elastin by oxidation, thus maintaining the rigidity and structural stability of the extracellular matrix (ECM). Aberrant expression or activation of LOX alters the cellular microenvironment, leading to many diseases, including atherosclerosis, tissue fibrosis, and cancer. Recently, a number of studies have shown that LOX is overexpressed in most cancers and that it is involved in the regulation of tumor progression and metastasis. In contrast, a few reports have also indicated the tumor-suppressing role of LOX. In this short review, we discuss recent research on the correlations between LOX and cancer. Further, the role of LOX in tumor microenvironment remodeling, tumorigenesis, and metastasis and the underlying mechanisms have also been elucidated.

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Section: Dietary Components Regulate Lox Activitymentioning

confidence: 99%

Lysyl Oxidase and the Tumor Microenvironment

Wang

Hsia

Shieh

2016

IJMS

137

102

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“…Several scientific studies have shown that tea contains high levels of antioxidant polyphenols, such as flavonoids and catechins [19][20][21][22][23]. These polyphenolic compounds can eliminate the dangerous free radicals such as superoxide anion radicals (O 2 •), hydrogen peroxide (H 2 O 2 •), and hydroxyl radicals (HO•), thereby preventing the progression of various diseases such as cancers [24,25] (e.g., prostate gland cancer [26], lung cancer [27]), osteoporosis [28], cardiovascular diseases [29] and Parkinson's disease [30], abdominal aortic aneurysm [31].…”

Section: Introductionmentioning

confidence: 99%

Polyvinyl Alcohol/Sodium Alginate Hydrogels Incorporated with Silver Nanoclusters via Green Tea Extract for Antibacterial Applications

Wang

Zhang

Zhao

et al. 2020

Designed Monomers and Polymers

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Silver-based nanoparticles and biomaterials have extensive biomedical applications owing to their unique antimicrobial properties. Thus, green and facile synthesis of such materials is highly desirable. This study reports an antibacterial hydrogel based on polyvinyl alcohol/sodium alginate network with the incorporation of silver nanoparticles (AgNPs), which is greenly synthesized by reductive metabolites obtained from the leaves of green tea. The 'flower-shape' AgNPs were acquired, it formed a mono-disperse system with a distinct uniform interparticle separation. The average size of AgNPs varied from 129.5 to 243.6 nm, which could be regulated by using different volumes of the green tea extract. Zeta potentials of the AgNPs were from −39.3 mV to −20.3 mV, indicating the moderate stability of the particles in water. In the next stage, the antibacterial polyvinyl alcohol/sodium alginate hydrogels were fabricated by incorporating prepared AgNPs. Scanning Electron Microscopy (SEM) images showed that the porous structure was obtained, and Energy Dispersive X-Ray (EDX) analysis confirmed that the AgNPs were uniformly dispersed in the polymer network. The hydrogels exhibited superior water absorption properties, which were characterized by a high swelling ratio (500-900%) and fast equilibrium. The hydrogels also exhibited good antimicrobial activity in assays with Gram-positive bacteria Escherichia coli and Gram-negative bacteria Staphylococcus aureus. To sum up, a process for the green preparation of antibacterial hydrogels based on AgNPs derived from tea leaves as a conveniently available cheap local agricultural product was established.

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“…We have shown that polyphenols such as pentagalloyl glucose (PGG) and Epigallocatechin gallate (EGCG) can increase elastin deposition by smooth muscle cells derived from healthy or aneurysmal rat aorta [4]. Others have shown than in an elastase model of AAA, a high dose of grape seed polyphenol used orally has a protective role for elastin, and decrease immune cells and MMPs at the AAA site [5]. Green tea polyphenol EGCG was used orally to a rat model of abdominal aortic aneurysm induced by intraluminal infusion of elastase and adventitial simultaneous CaCl 2 application where EGCG prevented the progression of AAA [5].…”

Section: Introductionmentioning

confidence: 99%

“…Others have shown than in an elastase model of AAA, a high dose of grape seed polyphenol used orally has a protective role for elastin, and decrease immune cells and MMPs at the AAA site [5]. Green tea polyphenol EGCG was used orally to a rat model of abdominal aortic aneurysm induced by intraluminal infusion of elastase and adventitial simultaneous CaCl 2 application where EGCG prevented the progression of AAA [5]. These studies used excessively high oral doses of polyphenols at the onset of AAA induction and showed an only protective effect.…”

Section: Introductionmentioning

confidence: 99%

Nanoparticle-based targeted delivery of pentagalloyl glucose reverses elastase-induced abdominal aortic aneurysm and restores aorta to the healthy state in mice

Dhital

Vyavahare

2020

PLoS ONE

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Abdominal aortic aneurysms (AAA) is a life-threatening weakening and expansion of the abdominal aorta due to inflammatory cell infiltration and gradual degeneration of extracellular matrix (ECM). There are no pharmacological therapies to treat AAA. We tested the hypothesis that nanoparticle (NP) therapy that targets degraded elastin and delivers antiinflammatory, anti-oxidative, and ECM stabilizing agent, pentagalloyl glucose (PGG) will reverse advance stage aneurysm in an elastase-induced mouse model of AAA. Method and results Porcine pancreatic elastase (PPE) was applied periadventitially to the infrarenal aorta in mice and AAA was allowed to develop for 14 days. Nanoparticles loaded with PGG (EL-PGG-NPs) were then delivered via IV route at 14-day and 21-day (10 mg/kg of body weight). A control group of mice received no therapy. The targeting of NPs to the AAA site was confirmed with fluorescent dye marked NPs and gold NPs. Animals were sacrificed at 28-d. We found that targeted PGG therapy reversed the AAA by decreasing matrix metalloproteinases MMP-9 and MMP-2, and the infiltration of macrophages in the medial layer. The increase in diameter of the aorta was reversed to healthy controls. Moreover, PGG treatment restored degraded elastic lamina and increased the circumferential strain of aneurysmal aorta to the healthy levels. Conclusion Our results support that site-specific delivery of PGG with targeted nanoparticles can be used to treat already developed AAA. Such therapy can reverse inflammatory markers and restore arterial homeostasis.

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Prevention of abdominal aortic aneurysm progression by oral administration of green tea polyphenol in a rat model

Abstract: EGCG attenuated AAA progression in a rat model by preserving the aortic thickness and elastin content of the medial layer through regeneration of elastin, as mediated by anti-inflammatory effects, and subsequent reduction of matrix metalloproteinase activity.

Cited by 29 publications

References 36 publications

Lysyl Oxidase and the Tumor Microenvironment

Lysyl Oxidase and the Tumor Microenvironment

Polyvinyl Alcohol/Sodium Alginate Hydrogels Incorporated with Silver Nanoclusters via Green Tea Extract for Antibacterial Applications

Nanoparticle-based targeted delivery of pentagalloyl glucose reverses elastase-induced abdominal aortic aneurysm and restores aorta to the healthy state in mice

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