Prevention of Alloxan-Induced Diabetes Mellitus in the Rat by Silymarin

Soto, Claudia; Perez, Blanca Lizaola; Favari, Liliana; Reyes, José L.

doi:10.1016/s0742-8413(97)00198-9

Cited by 83 publications

(74 citation statements)

References 29 publications

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“…34 Similar results have been shown by Soto et al on alloxan-induced diabetic rats. 35 In this study, no significant difference was observed in BS of STZ-induced diabetic rats after the administration of silymarin and milk thistle extract. This was similar to the study performed by Anjaneyulu et al regarding the effect of quercetin 27 and the recent study on the effect of mangiferin, a polyphenol, on STZinduced diabetic rats.…”

Section: Prevention Of Diabetic Nephropathy By Milk Thistle Extract Imentioning

confidence: 48%

Silymarin and milk thistle extract may prevent the progression of diabetic nephropathy in streptozotocin-induced diabetic rats

et al. 2010

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Objectives:To investigate the effect of silymarin and milk thistle extract on the progression of diabetic nephropathy (DN) in rats. Methods: Diabetes was induced with a single intraperitoneal (IP) injection of streptozotocin (STZ) (60 mg/kg). Silymarin (100 mg/kg/d) or the extract (1.2 g/kg/d) was gavaged for 4 weeks. Blood glucose (BS), serum urea (S u ), serum creatinine (S cr ), and 24-h urine protein (Up) were measured and glomerular filtration rate (GFR) was calculated. Concentration of thiobarbituric acid reactive species (TBARS) and activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), and catalase (CAT) were evaluated in the renal tissue. Results: Data were expressed as mean ± SEM. Silymarin or the extract had no significant effect on BS, S cr , and GFR. Both milk thistle extract and silymarin, respectively, decreased S u (mg/dL) (87.1 ± 7.78, p < 0.001; 84.5 ± 7.15, p < 0.001), Up (mg) (5.22 ± 1.56, p = 0.014; 5.67 ± 0.86, p = 0.034), and tissue TBARS (nmol/mg protein) (0.67 ± 0.04, p < 0.001; 0.63 ± 0.07, p < 0.001) in diabetic rats, compared to diabetic control (DC) (S u : 131.0 ± 4.55, Up: 8.3 ± 0.84, TBARS: 0.94 ± 0.06). Both the extract and silymarin could increase the activity of CAT (IU/mg protein) (25.5 ± 4.0, p = 0.005; 20 ± 1.8, p = 0.16) and GPx (IU/mg protein) (0.86 ± 0.05, p = 0.005; 0.74 ± 0.04, p = 0.10), respectively, in diabetic rats compared to DC (CAT = 14.4 ± 2.0, GPx = 0.57 ± 0.02). Conclusion: Milk thistle extract, to a lesser extent silymarin, can attenuate DN in rats possibly by increasing kidney CAT and GPx activity and decreasing lipid peroxidation in renal tissue.

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Section: Prevention Of Diabetic Nephropathy By Milk Thistle Extract Imentioning

confidence: 48%

Silymarin and milk thistle extract may prevent the progression of diabetic nephropathy in streptozotocin-induced diabetic rats

et al. 2010

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“…In alloxan-induced diabetic rats, silibin reduced serum glucose levels and protected the pancreas of rats from alloxan-induced lipid peroxidation by maintaining levels of malondialdehyde (MDA) and glutathione lower [14]. In silimarin-treated diabetic rats, normalization of glucose levels began after the first week of administration and reached the values of controls nine weeks afterwards, while insulin levels normalized after 7 days of treatment.…”

Section: Animal In Vivo Studiesmentioning

confidence: 99%

The Therapeutic Potential of Milk Thistle in Diabetes

Kazazis¹,

Evangelopoulos²,

Kollas³

et al. 2014

Rev Diabet Stud

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■ AbstractMilk thistle has been known for more than 2.000 years as a herbal remedy for a variety of disorders. It has mainly been used to treat liver and gallbladder diseases. Silibum marianum, the Latin term for the plant, and its seeds contain a whole family of natural compounds, called flavonolignans. Silimarin is a dry mixture of these compounds; it is extracted after processing with ethanol, methanol, and acetone. Silimarin contains mainly silibin A, silibin B, taxifolin, isosilibin A, isosilibin B, silichristin A, silidianin, and other compounds in smaller concentrations. Apart from its use in liver and gallbladder disorders, milk thistle has recently gained attention due to its hypoglycemic and hypolipidemic properties. Recently, a substance from milk thistle has been shown to possess peroxisome proliferator-activated receptor γ (PPARγ) agonist properties. PPARγ is the molecular target of thiazolidinediones, which are used clinically as insulin sensitizers to lower blood glucose levels in diabetes type 2 patients. The thiazolidinedione type of PPARγ ligands is an agonist with a very high binding affinity. However, this ligand type demonstrates a range of undesirable side effects, thus necessitating the search for new effective PPARγ agonists. Interestingly, studies indicate that partial agonism of PPARγ induces promising activity patterns by retaining the positive effects attributed to the full agonists, with reduced side effects. In this review, the therapeutic potential of milk thistle in the management of diabetes and its complications are discussed.

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“…Upasani et al (2001) showed that the preventive activity of vitamins C and E may related to their antioxidant efficacy that inhibits lipid peroxidation. Silymarin is a natural mixture of antioxidants acting as free radical scavenger and preventing lipid peroxidation (Soto et al, 1998). It was reported that silymarin improves liver function tests related to hepatocellular necrosis and/or increases membrane permeability (Buzzelli et al, 1993).…”

Section: Effect Of Antioxidant Treatmentmentioning

confidence: 99%

The protective efficacy of vitamins (C and E), selenium and silymarin supplements against alcohol toxicity

Shalan

Ali²,

Shalan

2010

World rabbit sci.

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ABSTRACT:This study aimed at investigating the efficacy of vitamins (C and E), selenium and silymarin (an antioxidant complex from Silybum marianum) supplementation in reducing toxic effects of ethanol on liver weight and some blood parameters. Sixty male rabbits, individually housed in steel cages, were randomly divided into three groups. The first was a control group, the second received balanced diet and daily 20% (v/ v) ethyl alcohol in their drinking water, the third received the same diet and 20% (v/v) ethanol in their drinking water and treated with vitamin C (1 mg/100 g body weight, BW), vitamin E (1 mg/100 g BW), selenium (0.01 mg/ 100 g BW) and silymarin (1 mg/100 g body weight) by gastric tube daily. Five animals per group were slaughtered every two weeks and liver and blood samples were taken after 2, 4, 6 and 8 weeks of treatment. Ethanol decreased body weight of rabbits and induced hepatomegally and apoptotic DNA fragmentation in hepatocytes. Chronic alcohol consumption induced significant increases in serum glucose, triglycerides and cholesterol levels whereas serum total protein content decreased. Significant increases in serum ALT, AST, ALP and LDH activities were observed in ethanol-treated rabbits. The treatment of alcohol-abused animals with vitamins (C and E), selenium and silymarin enhanced significant improvement in the biochemical, physiological and molecular aspects indicating their protective effects against alcohol toxicity.

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Prevention of Alloxan-Induced Diabetes Mellitus in the Rat by Silymarin

Cited by 83 publications

References 29 publications

Silymarin and milk thistle extract may prevent the progression of diabetic nephropathy in streptozotocin-induced diabetic rats

Silymarin and milk thistle extract may prevent the progression of diabetic nephropathy in streptozotocin-induced diabetic rats

The Therapeutic Potential of Milk Thistle in Diabetes

The protective efficacy of vitamins (C and E), selenium and silymarin supplements against alcohol toxicity

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