Prevention of bacterial colonization of intravenous catheters by antiseptic impregnation of polyurethane polymers

Bach, A.; Böhrer, H.; Motsch, J.; Martin, Eike; Hk, Geiss; Hg, Sonntag

doi:10.1093/jac/33.5.969

Cited by 63 publications

(5 citation statements)

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“…However, traditional methods mostly rely on the incorporation of antimicrobial drugs/nanoparticles/peptides into the device matrix or a coating of antibiotics on the device surface with limited effectiveness (Leipziger et al, 1985; Costache et al, 2010; Wiegand et al, 2011). The main challenge is the rapid loss of antibiotics and the compromise of device or material functionalities including mechanical properties, degradation rate, and biocompatibility (Bach et al, 1994; O’Meara et al, 2000). …”

Section: Introductionmentioning

confidence: 99%

Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers

Xie

Zhang

et al. 2014

Front. Bioeng. Biotechnol.

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Citrate-based polymers possess unique advantages for various biomedical applications since citric acid is a natural metabolism product, which is biocompatible and antimicrobial. In polymer synthesis, citric acid also provides multiple functional groups to control the crosslinking of polymers and active binding sites for further conjugation of biomolecules. Our group recently developed a number of citrate-based polymers for various biomedical applications by taking advantage of their controllable chemical, mechanical, and biological characteristics. In this study, various citric acid derived biodegradable polymers were synthesized and investigated for their physicochemical and antimicrobial properties. Results indicate that citric acid derived polymers reduced bacterial proliferation to different degrees based on their chemical composition. Among the studied polymers, poly(octamethylene citrate) showed ~70–80% suppression to microbe proliferation, owing to its relatively higher ratio of citric acid contents. Crosslinked urethane-doped polyester elastomers and biodegradable photoluminescent polymers also exhibited significant bacteria reduction of ~20 and ~50% for Staphylococcus aureus and Escherichia coli, respectively. Thus, the intrinsic antibacterial properties in citrate-based polymers enable them to inhibit bacteria growth without incorporation of antibiotics, silver nanoparticles, and other traditional bacteria-killing agents suggesting that the citrate-based polymers are unique beneficial materials for wound dressing, tissue engineering, and other potential medical applications where antimicrobial property is desired.

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Section: Introductionmentioning

confidence: 99%

Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers

Xie

Zhang

et al. 2014

Front. Bioeng. Biotechnol.

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“…The biofilms have been considered to diminish the activity of antibacterials, phagocytic cells, humoral antagonists and others (20, 21). Some general etiologic agents associated with biomaterial-related infections include Escherichia coli , Proteus mirabilis , Staphylococcus epidermidis , Enterococcus faecalis and Candida albicans (7, 13, 19, 22). …”

Section: Discussionmentioning

confidence: 99%

“…Other methods include the use of silver (25), and physicochemical surface modification (26-28). However, major problems in all these approaches were the fast or irregular release and the initial burst of antibacterial agents, leading to an erroneous infection during the contact (13, 15, 29). …”

Section: Discussionmentioning

confidence: 99%

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Biodegradable Polymer Releasing Antibiotic Developed for Drainage Catheter of Cerebrospinal Fluid: In Vitro Results

et al. 2005

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The authors developed a biodegradable polymer that releases an antibiotic (nalidixic acid) slowly and continuously, for prevention of catheter-induced infection during drainage of cerebrospinal fluid. We investigated the in vitro antibiotic releasing characteristics and bacterial killing effects of the new polymer against E. coli. The novel fluoroquinolone polymer was prepared using diisopropylcarbodiimide, poly (e-caprolactone) diol, and nalidixic acid. FT-IR, mass spectrometry, and elemental analysis proved that the novel antibacterial polymer was prepared successfully without any side products. Negative MS showed that the released drug has a similar molecular weight (M.W.=232, 350) to pure drug (M.W.=232). In high pressure liquid chromatography, the released drug and drug-oligomer showed similar retention times (about 4.5-5 min) in comparison to pure drug (4.5 min). The released nalidixic acid and nalidixic acid derivatives have antibacterial characteristics against E. coli, Staphylococcus aureus, and Salmonella typhi, of more than 3 months duration. This study suggests the possibility of applying this new polymer to manufacture drainage catheters that resist catheter-induced infection, by delivering antibiotics for a longer period of more than 1 month.

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“…An important issue is that once being initiated, the diffusion process will proceed, without any on/off control, until all of the drug stored in the polymer matrix is released. Quite often this occurs over a short period of time and may result in the delivery of a local and temporary excess of drug. ,, Polymeric carriers have been developed that contain drug moieties as terminal groups, or as pendent groups on the polymer chain. Polymers used for conjugation with drugs have included poly(α-amino acids), polysaccharides such as dextrans and chitin, polyurethanes, − and others. , The reports by Nathan are perhaps most relevant to the work discussed in this paper since they relate to polyurethanes.…”

Section: Introductionmentioning

confidence: 99%

Utilization of Quinolone Drugs as Monomers: Characterization of the Synthesis Reaction Products for Poly(norfloxacin diisocyanatododecane polycaprolactone)

Yang

Santerre

2000

Biomacromolecules

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A broad spectrum antimicrobial agent, 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(1-piperazinyl)-3-quinolinecarboxylic acid (norfloxacin), has been successfully incorporated as a monomer into a polyurethane backbone structure via a three-step polymerization of norfloxacin, diisocyanatododecane (DDI), and polycaprolactone diol (PCL). The reaction was catalyzed by dibutyltin dilaurate and carried out in dimethyl sulfoxide. The sequential order of monomer feeding had a strong influence on the polymerization behavior and final polymer structure. In the preferred reaction scheme norfloxacin is initially reacted with DDI to form an oligomer. This is followed by a second reaction where PCL is introduced in order to produce a drug polymer chain with higher molecular weight and degradable segments. Cross-linking of urea linkages between the norfloxacin and DDI segments was a particular concern and was minimized by feeding PCL into the reaction system immediately following the completion of the first step. Chain extension by 1,4-butanediol or ethylenediamine was shown to be an effective approach for increasing the molecular weight of the polymers.

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Prevention of bacterial colonization of intravenous catheters by antiseptic impregnation of polyurethane polymers

Cited by 63 publications

References 0 publications

Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers

Study on the Antimicrobial Properties of Citrate-Based Biodegradable Polymers

Biodegradable Polymer Releasing Antibiotic Developed for Drainage Catheter of Cerebrospinal Fluid: In Vitro Results

Utilization of Quinolone Drugs as Monomers: Characterization of the Synthesis Reaction Products for Poly(norfloxacin diisocyanatododecane polycaprolactone)

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