Prevention of bladder cancer incidence and recurrence

Fankhauser, Christian Daniel; Mostafid, Hugh

doi:10.1097/mou.0000000000000452

Cited by 55 publications

(38 citation statements)

References 43 publications

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“…Treatment for BCs, especially for the invasive type MIDB remains great challenge owing to high recurrence following surgical resection and drug administration. Aside from the unfavorable prognosis, the huge economic cost in lifetime surveillance with periodic cystoscopy and evaluation of recurrence rate brings considerable burden to BCs patients [14][15][16]. It has been as an emerging consensus that aberrant expression of some miRNAs, either extremely high or poor expression, is closely correlated with BCs pathogenesis [17].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-381 inhibits bladder cancer pathogenesis through directly controlling BMI1 and triggering the Rho/ROCK signaling pathway defect

Chen

Liu

Cao

et al. 2020

Preprint

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Background Emerging evidence has noted the important participation of microRNAs (miRNAs) in several human diseases including cancer control. This research was launched to probe the function of miR-381 in bladder cancer (BCs) progression. Methods Aberrantly expressed miRNAs in BCs tissues were analyzed using miRNA microarrays. miR-381 expression in the bladder and paired tumor tissues, and in BCs and normal cell lines was determined. The target relationship between miR-381 and BMI1 was predicted online and validated through a luciferase assay. Gain-of-functions of miR-381 and BMI1 were performed to identify their functions on BCs cell behaviors as well as tumor growth in vivo. Results miR-381 was poor regulated in BCs tissues and cells. A higher miR-381 level indicates a better prognosis of patients with BCs. Artificial up-regulation of miR-381 inhibited proliferation, invasion, migration, resistance to apoptosis, and tumor formation ability of BCs cells. miR-381 directly binds to BMI1 expression. Overexpression of BMI1 partially blocked the tumor suppressing roles of miR-381 in cell malignancy and tumor growth. In addition, miR-381 led to decreased RhoA phosphorylation and ROCK2 activation, which were also reversed by BMI1. Conclusion The study evidenced that miR-381 may act as a beneficiary biomarker in BCs patients. Up-regulation of miR-381 could suppress BCs development both in vivo and in vitro through BMI1 down-regulation and the Rho/ROCK inactivation.

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Section: Discussionmentioning

confidence: 99%

MicroRNA-381 inhibits bladder cancer pathogenesis through directly controlling BMI1 and triggering the Rho/ROCK signaling pathway defect

Chen

Liu

Cao

et al. 2020

Preprint

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“…Bladder cancer is a heterogeneous disease with unpredictable clinical course, representing a leading cancer-related deaths [15]. At present, there are several major risk factors identi ed in bladder cancer, such as cigarette smoking, chronic infection by Schistosoma haematobium, and exposure to the carcinogens [16,17]. Early diagnosis and close monitoring are key for clinical outcomes of patients with bladder cancer.…”

Section: Discussionmentioning

confidence: 99%

Urine MACC1 Plays an Indicative Role in Diagnosing Bladder Cancer

Tao

Gao

et al. 2020

Preprint

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Background: Present study aimed to estimate the diagnostic efficacy of urine Metastasis-associated in colon cancer 1 (MACC1) for bladder cancer patients.Methods: Urine MACC1 expression was measured in bladder cancer patients and controls via quantitative real-time polymerase chain reaction (qRT-PCR) assay. Chi-square test was used to assess the correlation of urine MACC1 levels with clinicopathological features of the patients. The diagnostic performance of urine MACC1 was evaluated by receiver operating characteristics (ROC) curve.Results: Urine MACC1 was obviously elevated in bladder cancer patients compared with controls (P<0.001). What’s more, abnormal urine MACC1 expression was significantly correlated with differentiation (P=0.013), tumor stage (P=0.023), lymph node metastasis (P=0.033) and distant metastasis (P=0.026). Furthermore, according to ROC analysis, urine MACC1 could distinguish bladder cancer patients from controls with an AUC (the areas under the ROC curve) of 0.909. The cut-off value of urine MACC1 for bladder cancer diagnosis was 1.275, with 79.8% specificity and 87.3% sensitivity.Conclusion: Urine MACC1 may be act as a biomarkers for diagnosis of bladder cancer.

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“…We also considered whether the patient had cancer. Urinary bladder cancer in women is increasing, although its incidence is 3-4 times lower than that in men [12].Unfortunately, bladder cancer is more often discovered at advanced stages in women [12]. Endocervical adenocarcinoma would be a reasonable consideration, had the patient not previously undergone total hysterectomy [2].…”

Section: Discussionmentioning

confidence: 99%

Metastatic mesonephric adenocarcinoma of unknown origin after hysterectomy: A case report

2020

European Journal of Gynaecological Oncology

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Müllerian and Wolffian ducts originate from the mesodermal tissue. In females, the Müllerian ducts develop to form the fallopian tubes, uterus, cervix, and upper two-thirds of the vagina; whereas in males, they regress. The Wolffian duct, also called the mesonephric duct, regresses in females during development. Mesonephric carcinomas occur through the female genital tract, and the majority arise in the cervix of the uterus. We report the case of a patient who had abdominal pain 4 weeks prior to admission, and who underwent a hysterectomy 20 years prior. The radiologic results revealed a 6.7 × 5.4 × 4.3 cm-sized mass in the retroperitoneum but were not indicative of mesonephric adenocarcinoma. The patient underwent complete mass surgical resection, followed by posterior sectionectomy of the liver and splenectomy with cholecystectomy. The histopathologic results showed that the mass was a mesonephric adenocarcinoma.

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Prevention of bladder cancer incidence and recurrence

Abstract: Several dietary items and life styles are associated with bladder cancer incidence and recurrence. However, besides smoking cessation, there is no evidence that a certain diet or lifestyle can decrease bladder cancer incidence.

Cited by 55 publications

References 43 publications

MicroRNA-381 inhibits bladder cancer pathogenesis through directly controlling BMI1 and triggering the Rho/ROCK signaling pathway defect

MicroRNA-381 inhibits bladder cancer pathogenesis through directly controlling BMI1 and triggering the Rho/ROCK signaling pathway defect

Urine MACC1 Plays an Indicative Role in Diagnosing Bladder Cancer

Metastatic mesonephric adenocarcinoma of unknown origin after hysterectomy: A case report

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