Prevention of Bladder Tumor Recurrence

Continuous bladder irrigation after transurethral resection of non‐muscle invasive bladder cancer for prevention of tumour recurrence: a systematic review

“…A smaller single‐centre trial from Israel, published as part of a book chapter, compared 31 participants receiving 12 L of water over 24 h post‐TURBT to 38 participants receiving no CBI. The recurrence rate at 24 months was significantly lower in the irrigated group (25% versus 58%, P = 0.007) but no difference was seen with longer follow‐up to 10 years (37% versus 31%, P = 0.61) 16 …”

“…The recurrence rate at 24 months was significantly lower in the irrigated group (25% versus 58%, P = 0.007) but no difference was seen with longer follow-up to 10 years (37% versus 31%, P = 0.61). 16 Three trials have compared CBI to IC, with the results from one having been presented in two separate publications (Table 2). A single-centre RCT from Kurashaki Central Hospital in Japan compared 20 h of CBI with saline to 20 h of epirubicin instillation.…”

“…In this systematic review, we have found six publications based on five prospective RCTs examining the effect of CBI on recurrence of NMIBC, two comparing CBI to no CBI and three comparing CBI to IC. Neither of the two trials comparing CBI to no CBI have been published in full but were included on the basis that sufficient published data were available from a conference abstract and book chapter, respectively 15,16 . Each trial demonstrated a lower risk of recurrence at 2 years with CBI.…”

Continuous Bladder Irrigation after Transurethral Resection of Non-Muscle Invasive Bladder Cancer for Prevention of Tumour Recurrence – A Systematic Review

“…The recurrence rate at 24mo was significantly lower in the irrigated group (25% vs 58%, p=0.007) but no difference was seen with longer follow-up to 10 years (37% vs 31%, p=0.61). 16 Three trials have compared CBI to IC, with the results from one having been presented in two separate publications (Table 2). A single-centre RCT from Kurashaki Central Hospital in Japan compared 20h of CBI with saline to 20h of Epirubicin instillation.…”

Continuous saline bladder irrigation for two hours following transurethral resection of bladder tumors in patients with non-muscle invasive bladder cancer does not prevent recurrence or progression compared with intravesical Mitomycin-C

“…[ 20 ] In the urologic literature, Moskovitz et al first postulated in 1987 that intravesical irrigation with distilled water during and after TURBT would lead to fewer recurrences. [ 21 ] While several small studies have demonstrated conflicting results regarding the use of water irrigation compared with no perioperative treatment, no studies have compared CSBI to MMC until the aforementioned studies by Onishi et al [ 10 , 14 , 22 , 23 ] Our study is the first to compare a shorter, perioperative duration of CSBI to both MMC and no perioperative treatment, and to evaluate this strategy in a heterogeneous patient population with low, intermediate, and high risk disease.…”