Prevention of Calcium Oxalate Crystal Formation with Medicinal Mushroom Extract with Antioxidant Activity in a Rat Model

Wagmaister, Jonathan; Gopal, N; Patel, Neel; Choudhury, Muhammad; Eshghi, Majid; Konno, Sensuke

doi:10.5455/jcmr.2020.11.01.39

Cited by 1 publication

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“…15 This was more likely due to sensitization of insulin receptor (IR) and insulin receptor substrate 1 (IRS-1) with SXF, 15 reactivating the insulin signal transduction pathway to facilitate an uptake of serum glucose by muscle and adipose cells. In addition, other mushrooms have been shown to possibly prevent Alzheimer's disease and osteoporosis, 16,17 slow down the progression of chronic kidney disease (CKD), 18 weight loss, skin juvenilization 19 etc. Taken together, mushrooms appear to have the known and unidentified potentials, which may provide us with great health benefits.…”

Section: Other Pharmacological Effects Of Mushroom Extractsmentioning

confidence: 99%

Significance of Mushrooms in Urological Diseases and Disorders

Konno,

Penunuri,

Wong

2024

Int J Health Sci Res

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Background: Since a number of medicinal mushrooms have various pharmacological properties, we have been studying them mainly for urological diseases/disorders over 24 years. Among them, we present herein the interesting study of anticancer effect of a mushroom on urological cancers to illustrate the significance of mushrooms in urology. Materials and Methods: Anticancer effect of maitake mushroom extract (PDF) on prostate cancer PC-3 cells in vitro was assessed by cell viability assay, and its synergistic potentiation with vitamin C (VC) was also demonstrated. Whether oxidative stress (OXS) may play a significant role in the anticancer mechanism was also explored. In addition, a possible chemosensitizing effect of PDF, capable of enhancing anticancer activity of chemotherapeutic drugs, was examined. Results: PDF alone led to a significant reduction in PC-3 cell viability, which became even greater when combined with VC, exhibiting <10% cell viability. Such a profound cell viability reduction was primarily attributed to apoptosis induced by OXS. Moreover, anticancer activity of certain drugs against prostate and bladder cancer cells was also improved when combined with PDF, indicating a chemosensitizing effect of PDF. Conclusion: This study demonstrates anticancer effect of PDF on urological cancer cells, and the PDF/VC combination is highly effective, ultimately leading to apoptosis. A chemosensitizing effect of PDF demonstrated here implies its possible clinical use as an adjuvant agent in current chemotherapy. Therefore, this study represents only anticancer effect of a mushroom but the significance of mushrooms in urological diseases/disorders can be yet understood. Key words: Mushrooms, Maitake, Anticancer, Medicinal properties, Urological diseases, Chemosensitization.

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