Prevention of Carbon Tetrachloride-induced Hepatic Steatosis and Cellular Damage by Aqueous Extract of Dacryodes edulis Seeds in Wistar Rats

Orhue, Noghayin E. Jerry; Adaikpoh, M. A.; Odude, O.; Iseghohi, Sylvia Oghogho

doi:10.4314/br.v13i1.144795

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Albino rats of the Wistar strain were treated with the seed extract for two weeks and then CCl 4 on the fourteenth day, showing no liver damage, whereas rats that were only subjected to CCl 4 showed liver damage [94]. Similarly, the same authors assessed the hepatoprotective activity of the seeds aqueous extract [95]. The liver section of male Wistar rats with CCl 4 -induced hepatotoxicity, treated with ethanol extract of D. edulis seeds, highlighted the potential of this extract to restore hepatocyte functions [96].…”

Section: Effect On Hepatocytesmentioning

confidence: 99%

“…Similarly, the same authors assessed the hepatoprotective activity of the seeds aqueous extract [95]. The liver section of male Wistar rats with CCl 4 -induced hepatotoxicity, treated with ethanol extract of D. edulis seeds, highlighted the potential of this extract to restore hepatocyte functions [96]. Furthermore, the hepatoprotective activity of the fruits of D. edulis was evaluated during their maturation from four weeks after anthesis to mature fruits on male Wister rats.…”

Section: Effect On Hepatocytesmentioning

confidence: 99%

See 1 more Smart Citation

The Genus Dacryodes Vahl.: Ethnobotany, Phytochemistry and Biological Activities

Swana,

Tsakem,

Tembu

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

Dacryodes Vahl. species, belonging to the Burseraceae family, are widely used in traditional medicine in tropical regions to treat a range of ailments including malaria, wounds, tonsillitis, and ringworms. This review discusses the distribution, ethnobotanical uses, phytochemistry, and bioactivities of Dacryodes species. The intent is to spur future research into isolating and identifying key active principles, secondary metabolites, and crude extracts, and evaluating their pharmacological and toxicological effects, as well as the mechanism of actions to understand their medicinal benefits. A systematic review of scientific electronic databases from 1963 to 2022 including Scifinder, Scopus, Pubmed, Springer Link, ResearchGate, Ethnobotany Research and Applications, Google Scholar, and ScienceDirect was conducted with a focus on Dacryodes edulis (G.Don) H.J. Lam and Dacryodes rostrata (Blume) H.J. Lam. Pharmacological data revealed that D. edulis isolates contain secondary metabolites and other phytochemical groups belonging to the terpenoids class with anti-microbial, anticancer, antidiabetic, antiinflammatory and hepatoprotective activities, highlighting its pharmacological potential in the therapy or management of diverse cancers, cardiovascular, and neurological diseases. Thus, phytochemicals and standardized extracts from D. edulis could offer safer and cost-effective chemopreventive and chemotherapeutic health benefits/regimen, or as alternative therapeutic remedy for several human diseases. Nevertheless, the therapeutic potential of most of the plants in the genus have not been exhaustively explored with regard to phytochemistry and pharmacology, but mostly complementary approaches lacking rigorous, scientific research-based knowledge. Therefore, the therapeutic potentials of the Dacryodes genus remain largely untapped, and comprehensive research is necessary to fully harness their medicinal properties.

show abstract

Section: Effect On Hepatocytesmentioning

confidence: 99%

Section: Effect On Hepatocytesmentioning

confidence: 99%

The Genus Dacryodes Vahl.: Ethnobotany, Phytochemistry and Biological Activities

Swana,

Tsakem,

Tembu

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

Aqueous extract of Dennettia tripetala ameliorates liver and kidney damage caused by multiple exposures to carbon tetrachloride

Iseghohi

Orhue

2017

Clin Phytosci

View full text Add to dashboard Cite

Background: Dennettia tripetala is a medicinal plant with in vitro antioxidant activities. It is capable of protecting the liver and kidney of rats from damage when administered prior to a single exposure of carbon tetrachloride. The aim of this study was to document the possible ameliorative effect of the aqueous extract of Dennettia tripetala fruits on rats subjected to multiple exposures of carbon tetrachloride. Methods: Carbon tetrachloride was administered orally to male albino rats of Wistar strain four times over a 2 week period. The aqueous extract of Dennettia tripetala fruits was administered daily for 7 days starting on the 8th day after carbon tetrachloride administration had commenced. Results: Carbon tetrachloride caused increases in serum ALT, AST and ALP, serum total cholesterol, serum LDLcholesterol, liver total cholesterol and triglyceride, serum total protein, globulin, urea, creatinine as well as liver and kidney malondialdehyde levels. Carbon tetrachloride also caused significant reductions in serum HDL-cholesterol, serum triglyceride, serum albumin:globulin ratio as well as liver and kidney SOD and catalase activities. The plant extract was able to restore the biochemical parameters to levels comparable to those of the control group in all instances. Further evidence in support of these results was derived from histopathological analysis. Conclusion: Taken together, the results of this study show that the aqueous extract of Dennettia tripetala fruits is able to ameliorate liver and kidney damage caused by multiple exposures to carbon tetrachloride probably via an antioxidant-dependent mechanism.

show abstract

Extracts from Dacryodes edulis restored renal functions altered by CCl4 in rats

Akunne,

A. Alagbaoso,

E. J. Orhue

2023

pbp

View full text Add to dashboard Cite

The human body has evolved defense mechanisms for handling some toxic chemicals. However, the defense mechanisms are often overwhelmed resulting in tissue damage and disease. Recent studies have reported the therapeutic potential of Dacryodes edulis (D. edulis), but there is little or no report of its protective effects on the kidneys upon exposure to toxicants. In this study, the protective effect of D. edulis on the kidneys upon exposure to carbon tetrachloride (CCl4), a toxic environmental chemical, was investigated.Methods: An animal model of kidney damage from CCl4 was established with Wistar albino rats. The rats were orally treated with aqueous and methanol extracts of D. edulis at concentrations ranging from 100-400 mg/kg b. weight for 21 days followed by oral administration of CCl4 in olive oil for an additional one day.Plasma concentrations of electrolytes, activity of antioxidant enzymes, hematology, and kidney histology were studied to determine the effect of CCl4 on the kidneys. Results:The activity of catalase, superoxide dismutase, glutathione peroxidase, and malondialdehyde concentration in the kidneys increased significantly, indicating that CCl4 caused reactive oxygen species (ROS) production. A reduced concentration of reduced glutathione (GSH) was also observed in the kidneys of rats that received only CCl4. Aqueous and methanol extracts of D. edulis restored the activity of antioxidant enzymes and GSH concentration to their normal levels, which suggested that D. edulis possessed free radical scavenging properties. Plasma concentrations of Na + , K + , and Clas well as urea and creatinine concentrations that were high upon CCl4 exposure were significantly lowered on treatment with 400 mg/kg b. weight of both aqueous and methanol extracts of D. edulis. Conclusion:The altered plasma electrolytes, urea, and creatinine concentrations could be attributed to the damaging effects of ROS on the kidneys. Furthermore, both hematological and histological analyses indicated that D. edulis extracts protected the kidneys from the toxic effects of CCl4. These data suggested that D. edulis possessed protective bioactive components against kidney damage caused by CCl4.

show abstract

Prevention of Carbon Tetrachloride-induced Hepatic Steatosis and Cellular Damage by Aqueous Extract of Dacryodes edulis Seeds in Wistar Rats

Cited by 3 publications

References 0 publications

The Genus Dacryodes Vahl.: Ethnobotany, Phytochemistry and Biological Activities

The Genus Dacryodes Vahl.: Ethnobotany, Phytochemistry and Biological Activities

Aqueous extract of Dennettia tripetala ameliorates liver and kidney damage caused by multiple exposures to carbon tetrachloride

Extracts from Dacryodes edulis restored renal functions altered by CCl4 in rats

Contact Info

Product

Resources

About