Prevention of carbon tetrachloride-induced necrosis by inhibitors of drug metabolism—Further studies on their mechanism of action

Castro, J.A.; Ferreyra, E.C. de; Castro, Clementina; Fenos, O.M. de; Sasame, Henry A.; Gillette, James R.

doi:10.1016/0006-2952(74)90420-1

Cited by 121 publications

(58 citation statements)

References 9 publications

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“…The principle causes of carbon tetrachloride (CCl 4 ) induced hepatic damage are lipid peroxidation, generation of free radicals and decreased activities of antioxidant enzymes (Castro et al, 1974;Poli 1993). In this study, it has also been found that the MDA level has been elevated significantly (p<0.05) with the increase of CCl 4 concentration in the tissues (Fig.1B).…”

Section: Discussionsupporting

confidence: 63%

Carbon tetrachloride induced hepatorenal failure in male albino rats: a dose response study

Dassarma¹,

Samanta²,

Nandi³

et al. 2017

Int J Recent Sci Res

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Like other halogenated alkanes carbon tetrachloride or tetrachloromethane (CCl 4 ) induces hepatorenal injury in both acute and chronic cases in rats. Rats were sequentially administered with a dose of 115 mg/kg of body weight /day and 230 mg/kg of body weight /day respectively for 7 days and also an acute dose of 2000 mg/kg of body weight was also given for mortality, wellness parameter study. Several oxidative stress markers, biochemical parameters and liver and renal functions tests were measured. The present study was aimed to determine LD50 of CCl 4 by subcutaneous application in male rats as per the guidelines of Organization for Economic Cooperation and Development (OECD). Our results suggested that the CCl 4 induction causes hepatorenal toxicity by generation of liver fibrosis in experimental animals, at a concentration of 230 mg/kg bw/day in a time period of 7 days subcutaneous administration in male rats.

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Section: Discussionsupporting

confidence: 63%

Carbon tetrachloride induced hepatorenal failure in male albino rats: a dose response study

Dassarma¹,

Samanta²,

Nandi³

et al. 2017

Int J Recent Sci Res

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“…Antioxidants and anti-inflammatory agents can play a role in liver protection by scavenging active oxygen and free radicals and neutralizing lipid peroxides. The major causes of carbon tetrachloride (CCl 4 ) induced hepatic damage in lipid peroxidation and decreased activities of antioxidant enzymes and generation of free radicals (Castro et al, 1974). Liver injury caused by CCl 4 depends on its metabolite to the highly reactive trichloromethyl (CCl 3. )…”

Section: Introductionmentioning

confidence: 99%

Effect of Methanol Extract of Abrus precatorius Leaves on Male Wistar Albino Rats Induced Liver Damage using Carbon Tetrachloride (CCl4)

Uroko¹,

Adeyi²,

Hadiza³

et al. 2015

J. of Biological Sciences

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A B S T R A C T This study evaluates qualitative and quantitative phytochemical properties ofAbrus precatorius leaves. The vitamins and therapeutic effect of methanol extract against tetrachloride (CCl 4 ) induced liver damage in male Wistar albino rats. The results of phytochemical and vitamins indicates richness in saponins, tannins, alkaloids and flavonoids with value 30.05±0.22%, while vitamins such as thiamine, riboflavin, niacin, antioxidant and vitamins A, C and E was quantified. The liver damage was observed in the animals with significant increase in ALT, AST and ALP following the in traperitoneal administration of CCl 4 . The methanol extract caused significant decrease (p<0.05) in the activities of these enzymes in the treated animals relative to positive control that received CCl 4 but were not treated. The extract showed potentials to mopping-up of free radicals generated by CCl 4 . The extract reduced lipid peroxidation in concentration dependent manner. The findings suggests that the extract have the capacity to improving liver functions and liver regeneration at high concentration. The extracts are safe for consumption, abundant phytochemicals and antioxidant vitamins could offer reasonable protections against oxidative stress.

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“…Thus the antioxidant activity or the inhibition of the generation offree radicals is important in the protection against CCI 4 -induced hepatopathy. (4) Antioxidant action has been reported to play a crucial role in the hepatoprotective capacity of many plants, such as Curcuma /onga, Ganoderma formosanum, So/anum n/grum, Boehmer/a n/yea andSpiru//na maxima. (5)(6)(7)(8)(9) Ayurveda, an indigenous system of medicine in India, has a long tradition of treating liver disorders, with plant drugs.…”

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confidence: 99%

Antioxidant activity ofcurculigo orchioides in carbon tetrachloride—induced hepatopathy in rats

Venukumar

Latha

2002

Indian J Clin Biochem

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In this study antioxidant activity of methanol extract of rhizomes of Curculigo orchioides (MEC) was investigated using carbon tetrachloride (CCI4)-intoxicated rat liver asthe experimental model. The hepatotoxic rats were administered MEC for 90 days (daily, orally at the dose of 70 mg per kg body weight). Lipid peroxidation (LPO) in CCI4-intoxicated ratswas evidenced by a marked increment in the levels of thiobarbituric acid reactive substances (TBARS) and diene conjugates (CD), and also a distinct diminution in glutathione (GSH) content in the liver. In CCI 4 + MEC-treated rats these biochemical parameters attained an almost normal level. The decreased activity of antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPX) and glutathione reductase (GRD) in CCI4-intoxicated rats, and its retrieval towards near normalcy in CCI4+ MEC-administered rats revealed the efficacy of MEC in combating oxidative stress due to hepatic damage. Elevated level of glutathione transferase(GTS) observed in hepatotoxic rats too showed signs of returning towards normalcy in MEC co-administered animals, thus corroborating the antioxidant efficacy of MEC. The findings provide a rationale for further studies on isolation of active principles and its pharmacological evaluation. K E Y W O R D SAntioxidant enzymes, Carbon tetrachloride, Curcu/igo orchioides, Lipid peroxidation. I N T R O D U C T I O NCurculigo orchioides Gaertn. of Amaryllidaceae family is a herbaceous tuberous geophilous perennial with rootstock bearing several fleshy lateral roots (rhizomes). It is widely distributed in India. The rhizomes of this plant possess medicinal properties and are sweet, cooling, diuretic, aphrodisiac, viriligenic and tonic which can be used against hemorrhoids, leucorrhoea, pruritis, skin diseases, asthma, bronchitis and jaundice etc. (1) Curculigo saponin G, isolated from rhizomes of the plant has been reported to increase weight of thymus gland in vivo in mice. (2) Ethanolic extract of Corchio/deshas been reported to have sedative, anticonvulsant and androgen-like effect, and also Biochemistry, 2002 adaptive effects, such as enhancing tolerance towards hypoxia and hyperthermia (3). Our previous study (unpublished data) revealed hepatoprotective potential of methanol extract of C. orchioides. Therefore in the present work attempt has been made to study the antioxidant effect of Corch/o/des in CCI4-intoxicated experimental rats.It has been hypothesized that one of the principal causes of CCI4-induced liver injury is LPO by free radical derivatives of CCI 4 . Thus the antioxidant activity or the inhibition of the generation offree radicals is important in the protection against CCI 4 -induced hepatopathy. (4) Antioxidant action has been reported to play a crucial role in the hepatoprotective capacity of many plants, such as Curcuma /onga, Ganoderma formosanum, So/anum n/grum, Boehmer/a n/yea andSpiru//na maxima. (5-9) Ayurveda, an indigenous system of medicine in India, has a long tradition of tre...

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Prevention of carbon tetrachloride-induced necrosis by inhibitors of drug metabolism—Further studies on their mechanism of action

Cited by 121 publications

References 9 publications

Carbon tetrachloride induced hepatorenal failure in male albino rats: a dose response study

Carbon tetrachloride induced hepatorenal failure in male albino rats: a dose response study

Effect of Methanol Extract of Abrus precatorius Leaves on Male Wistar Albino Rats Induced Liver Damage using Carbon Tetrachloride (CCl4)

Antioxidant activity ofcurculigo orchioides in carbon tetrachloride—induced hepatopathy in rats

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