Prevention of complications from use of conventional immunosuppressants: a critical review

Ponticelli, Claudio; Glassock, Richard J.

doi:10.1007/s40620-019-00602-5

Cited by 77 publications

(77 citation statements)

References 148 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Measures to reduce the risk of steroid toxicity include dose reduction in the elderly and in obese subjects, use of steroid-sparing immunosuppressive agents, and administration of a single dose of a short-acting glucocorticoid in the morning between 7 and 9 a.m., in order to mimic the circadian rhythm of cortisol. Patients should be counseled to maintain regular physical activity to prevent myopathy and obesity, and to follow a low-calorie and low-salt diet to prevent hypertension, edema, obesity and cardiovascular disease (131,132). P. Jiroveci prophylaxis and use of biphosphonates in women over 50 years should be also considered.…”

Section: Treatment Of Primary Fsgsmentioning

confidence: 99%

Autoimmunity in Focal Segmental Glomerulosclerosis: A Long-Standing Yet Elusive Association

Podestà

Ponticelli²

2020

Front. Med.

Self Cite

View full text Add to dashboard Cite

Focal segmental glomerulosclerosis (FSGS) is a histological term that describes a pathologic renal entity affecting both adults and children, with a wide array of possible underlying etiologies. Podocyte damage with scarring, the hallmark of this condition, leads to altered permeability of the glomerular barrier, which may result in massive proteinuria and relentless renal function deterioration. A definite cause of focal segmental glomerulosclerosis can be confirmed in a minority of cases, while most forms have been traditionally labeled as primary or idiopathic. Despite this definition, increasing evidence indicates that primary forms are a heterogenous group rather than a single disease entity: several circulating factors that may affect glomerular permeability have been proposed as potential culprits, and both humoral and cellular immunity have been implicated in the pathogenesis of the disease. Consistently, immunosuppressive drugs are considered as the cornerstone of treatment for primary focal segmental glomerulosclerosis, but response to these agents and long-term outcomes are highly variable. In this review we provide a summary of historical and recent advances on the pathogenesis of primary focal segmental glomerulosclerosis, focusing on implications for its differential diagnosis and treatment.

show abstract

Section: Treatment Of Primary Fsgsmentioning

confidence: 99%

Autoimmunity in Focal Segmental Glomerulosclerosis: A Long-Standing Yet Elusive Association

Podestà

Ponticelli²

2020

Front. Med.

Self Cite

View full text Add to dashboard Cite

show abstract

“…Membranous nephropathy (MN) represents one of the most pressing fields of application given that this glomerulopathy represents the most frequent cause of nephrotic syndrome in adults and approximately one‐third of patients progress to end stage renal disease (ESRD) . Furthermore, there still remains a fair degree of heterogeneity in terms of patient response and outcomes following the administration of immunosuppressive treatment and a marker that can reliably predict the response of a patient to this therapeutic treatment a priori is lacking.…”

Section: Introductionmentioning

confidence: 99%

High Spatial Resolution MALDI‐MS Imaging in the Study of Membranous Nephropathy

Smith

L’Imperio

Denti

et al. 2018

Proteomics Clinical Apps

View full text Add to dashboard Cite

Purpose Matrix‐assisted laser desorption/ionization mass spectrometry imaging (MALDI‐MSI) technology has advanced rapidly during recent years with the development of instruments equipped with low‐diameter lasers that are suitable for high spatial resolution imaging. This may provide significant advantages in certain fields of molecular pathology where more specific protein fingerprints of individual cell types are required, such as renal pathology. Experimental design Here MALDI‐MSI analysis of a cohort of membranous nephropathy (MN) patients is performed among which patients either responded favorably (R; n = 6), or unfavorably (NR; n = 4), to immunosuppressive treatment (Ponticelli Regimen), employing a 10 µm laser spot diameter. Results Specific tryptic peptide profiles of the different cellular regions within the glomerulus can be generated, similarly for the epithelial cells belonging to the proximal and distal tubules. Conversely, specific glomerular and sub‐glomerular profiles cannot be obtained while using the pixel size performed in previous studies (50 µm). Furthermore, two proteins are highlighted, sonic hedgehog and α‐smooth muscle actin, whose signal intensity and spatial localization within the sub‐glomerular and tubulointerstitial compartments differ between treatment responders and non‐responders. Conclusions and clinical relevance The present study exemplifies the advantage of using high spatial resolution MALDI‐MSI for the study of MN and highlights that such findings have the potential to provide complementary support in the routine prognostic assessment of MN patients.

show abstract

“…Although both drugs are largely excreted by the biliary system, there is thought that cyclosporine may be partially eliminated through the skin's sebaceous glands given more frequent pilosebaceous involvement. 8 Nonetheless, we suspect that hypertrichosis and eyelash trichomegaly secondary to tacrolimus are likely under-reported. We now report a case and review several other published cases of localized hypertrichosis in patients receiving systemic or topical tacrolimus.…”

Section: F I G U R Ementioning

confidence: 93%

Localized hypertrichosis following tacrolimus therapy: A case report and brief review

Antoury¹,

Cheng

2021

Dermatologic Therapy

View full text Add to dashboard Cite

Oral tacrolimus is a mainstay of immunosuppression following solid organ transplantation. In cells, tacrolimus binds a cytoplasmic receptor to form a complex that competitively inhibits calcineurin, ultimately reducing the transcription of cytokines including interleukin-2 and impairing proliferation of T lymphocytes. 1 Cyclosporine is another calcineurin inhibitor used to prevent organ transplant rejection and immune-mediated diseases including rheumatoid arthritis and psoriasis. Hypertrichosis is an established side effect of

show abstract

Prevention of complications from use of conventional immunosuppressants: a critical review

Cited by 77 publications

References 148 publications

Autoimmunity in Focal Segmental Glomerulosclerosis: A Long-Standing Yet Elusive Association

Autoimmunity in Focal Segmental Glomerulosclerosis: A Long-Standing Yet Elusive Association

High Spatial Resolution MALDI‐MS Imaging in the Study of Membranous Nephropathy

Localized hypertrichosis following tacrolimus therapy: A case report and brief review

Contact Info

Product

Resources

About