Prevention of Complications of Respiratory Illnesses in Pediatric Practice

Townsend, Edward H.; Radebaugh, John F.

doi:10.1056/nejm196204052661401

Cited by 34 publications

(5 citation statements)

References 12 publications

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“…Any decision to treat children with acute otitis media with an antibacterial agent, requires that amoxicillin be prescribed because of its safety, low cost, acceptable taste, and narrow microbiologic spectrum 34,35. Treating influenza without established secondary bacterial infection with antibiotics has not proven beneficial36,37 yet eight of the nine patients diagnosed with influenza received antibiotics. Only 2 [1.8%] of the 112 children who had swab analyses showed growth of bacterial pathogens supporting the evidence that most URTIs are of viral origin.…”

Section: Discussionmentioning

confidence: 99%

Drugs in upper respiratory tract infections in paediatric patients in North Trinidad

Mungrue

Brown

Hayes

et al. 2009

Pharmacy Practice (Internet)

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Section: Discussionmentioning

confidence: 99%

Drugs in upper respiratory tract infections in paediatric patients in North Trinidad

Mungrue

Brown

Hayes

et al. 2009

Pharmacy Practice (Internet)

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“…Results: antibiotic no better than control group Townsend 1960 Excluded as used prophylactic antibiotics. Results: no benefit from antibiotics Townsend 1962 Excluded as control group not obtained by randomisation. Results: no benefits from antibiotics…”

Section: Sulman 1958mentioning

confidence: 99%

Antibiotics for the common cold and acute purulent rhinitis

Kenealy

Arroll

2013

Cochrane Database of Systematic Reviews

246

122

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“…Three of these four trials reported that antibiotic treatment had no effect on either relief of symptoms or subsequent complications in children (table 2). 23 24 26 …”

Section: Resultsmentioning

confidence: 99%

Systematic review of the treatment of upper respiratory tract infection

Fahey

Stocks

Thomas

1998

Archives of Disease in Childhood

114

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Objectives-To assess the risks and benefits of antibiotic treatment in children with symptoms of upper respiratory tract infection (URTI). Design-Quantitative systematic review of randomised trials that compare antibiotic treatment with placebo. Data sources-Twelve trials retrieved from a systematic search (electronic databases, contact with authors, contact with drug manufacturers, reference lists); no restriction on language. Main outcome measures-The proportion of children in whom the clinical outcome was worse or unchanged; the proportion of children who suVered complications or progression of illness; the proportion of children who had side eVects. Results-1699 children were randomised in six trials that contributed to the meta-analysis. Six trials were not used in the meta-analysis because of diVerent outcomes or incomplete data. Clinical outcome was not improved by antibiotic treatment (relative risk 1.01, 95% confidence interval (CI) 0.90 to 1.13), neither was the proportion of children suVering from complications or progression of illness (relative risk 0.71, 95% CI 0.45 to 1.12). Complications from URTI in the five trials that reported this outcome was low (range 2-15%). Antibiotic treatment was not associated with an increase in side eVects compared with placebo (relative risk 0.8, 95% CI 0.54 to 1.21). Conclusions-In view of the lack of eYcacy and low complication rates, antibiotic treatment of children with URTI is not supported by current evidence from randomised trials. (Arch Dis Child 1998;79:225-230)

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Prevention of Complications of Respiratory Illnesses in Pediatric Practice

Cited by 34 publications

References 12 publications

Drugs in upper respiratory tract infections in paediatric patients in North Trinidad

Drugs in upper respiratory tract infections in paediatric patients in North Trinidad

Antibiotics for the common cold and acute purulent rhinitis

Systematic review of the treatment of upper respiratory tract infection

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