Prevention of coronary artery disease in men: Male hormone, female hormone, or both?

Yang, Changsheng; Wang, Xiaoping; Geng, Chang-Ming; Ding, Huangen

doi:10.1016/j.mehy.2010.07.053

Cited by 5 publications

(3 citation statements)

References 35 publications

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“…Although both male and female sex hormones have been well-documented to be able to influence vascular biology and to play an important role in coronary artery disease 3-5,34-37, the steroid theory was not echoed by other studies. Yang found that 2D:4D ratios, measures of masculine characteristics, and salivary testosterone showed no significant associations with one another in both male and female 18.…”

Section: Discussionmentioning

confidence: 99%

The Ratio of Second to Fourth Digit Length (2D:4D) and Coronary Artery Disease in a Han Chinese Population

Wu¹,

Yang²,

Chai³

et al. 2013

Int. J. Med. Sci.

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Background: The association between index finger to ring finger length ratio (2D:4D) and cardiac disorders has been reported, however it has not been discussed in terms of coronary artery disease (CAD). We investigated whether 2D:4D could be used as a marker for predisposition to CAD as assessed by coronary angiography in Chinese men and women.Methods: This study included 1764 persons divided into 4 groups, 441 cases with CAD and 441 persons without CAD as control in each sex of the same age. Finger lengths were measured twice for both hands using electronic calipers. Student t test was used to detect the difference of 2D:4D among groups. The receiver operator characteristic curves (ROCs) were used to detect the diagnostic effect of 2D:4D for CAD.Results: There were no significant differences in age among the four groups. A significant difference of 2D:4D ratios between right and left hand were observed only in men in both control and CAD groups. On the right hand in the control group and on both hands in the CAD group, the 2D:4D ratios were higher in women than in men (all, P < 0.001). In men with CAD, mean 2D:4D was higher than mean 2D:4D in control men (right hand 0.962±0.042:0.927±0.038; left hand 0.950±0.044:0.934±0.048; both hands, P < 0.001), but this was not observed in women. No relationship was found between 2D:4D and age (all, P >0.05). The area under the curve of right hand 2D:4D in male was 0.72 (95% CI 0.683-0.753, p<0.001), while it was 0.602 (95% CI 0.565-0.639, p<0.001) in left hand.Conclusions: The present study showed an association between high 2D:4D ratio and CAD in both hands in men. There were no significant differences in mean 2D:4D between women with CAD and controls.

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Section: Discussionmentioning

confidence: 99%

The Ratio of Second to Fourth Digit Length (2D:4D) and Coronary Artery Disease in a Han Chinese Population

Wu¹,

Yang²,

Chai³

et al. 2013

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…CAD is a sex-dependent disease that is two to five times more common in middle-aged men than in their women counterparts; its incidence has decreased in men but has increased in women (Shively et al, 2009;Yang et al, 2010). Our results presented a remarkable association between rs9470079 and CAD in the female groups but not in the male groups.…”

Section: Discussionmentioning

confidence: 45%

Peer Review #1 of "Association of FKBP5 polymorphisms with patient susceptibility to coronary artery disease comorbid with depression (v0.1)"

2020

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Background : Coronary artery disease (CAD) and depression cause great burden to society and frequently co-occur. The exact mechanisms of this comorbidity are unclear. FK506-binding protein 51 (FKBP51) is correlated with cardiovascular disease and depression. The aim of this study was to determine the role of the seven single nucleotide polymorphisms (SNPs) of FKBP5 that code FKBP51, namely, rs1360780 (C>T), rs2817032 (T>C), rs2817035 (G>A), rs9296158 (G>A), rs9470079 (G>A), rs4713902 (T>C), and rs3800373 (C>T) in a patient's susceptibility to comorbid CAD and depression. Methods: We enrolled 271 Northern Chinese Han patients with CAD, including 123 patients with depression and 147 patients without depression. We also included 113 healthy controls that match the patients' sex and age. Genomic DNA from whole blood was extracted, and seven SNPs were assessed using MassArray method. Patient Health Questionnaire-9 was applied to access the depression. Results: The GA genotype for rs9470079 was associated with a significantly decreased risk of CAD (odds ratio = 0.506, 95% confidence interval = 0.316-0.810, P = 0.005) when the GG genotype was used as reference. A statistically significant difference was observed among females but not among males in the rs9470079 genotype and allele frequency. Patients with CAD were further divided into CAD+D and CAD-D groups according to the presence of comorbid depression and were compared with the controls. Significant differences were found regarding the genotype and allele frequency of rs2817035 and rs9470079 in CAD+H groups compared with the control subjects in all groups and the female groups (P < 0.05). Conclusions: The current study found a remarkable association between FKBP5 gene variations and the risk of comorbid CAD and depression in a north Chinese population. Rs9470079 may be a potential gene locus for the incidence of comorbid CAD and depression.

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“…The stratified analyses showed that the CC genotype of rs1132899 modestly increased the triglyceride (TG) levels compared in male subjects, whereas female subjects carrying CC genotype exhibited mildly decreased TG levels; 3. Sex hormones play an important role in coronary artery disease, a proper ratio of estrogen:testosterone is essential during CAD development s [ 30 ], which might account for the sex variance of rs1132899 polymorphism for the risk of CAD.…”

Section: Discussionmentioning

confidence: 99%

The association of APOC4 polymorphisms with premature coronary artery disease in a Chinese Han population

Cheng

et al. 2015

Lipids Health Dis

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BackgroundHypercholesterolemia arising from abnormal lipid metabolism is one of the critical risk factors for coronary artery disease (CAD), however the roles of genetic variants in lipid metabolism-related genes on premature CAD (≤60 years old) development still require further investigation. We herein genotyped four single nucleotide polymorphisms (SNPs) in lipid metabolism-related genes (rs1132899 and rs5167 in APOC4, rs1801693 and rs7765781 in LPA), aimed to shed light on the influence of these SNPs on individual susceptibility to early-onset CAD.MethodsGenotyping of the four SNPs (rs1132899, rs5167, rs1801693 and rs7765781) was performed in 224 premature CAD cases and 297 control subjects (≤60 years old) using polymerase chain reaction-ligation detection reaction (PCR–LDR) method. The association of these SNPs with premature CAD was performed with SPSS software.ResultsMultivariate logistic regression analysis showed that C allele (OR = 1.50, P = 0.027) and CC genotype (OR = 2.84, P = 0.022) of APOC4 rs1132899 were associated with increased premature CAD risk, while the other three SNPs had no significant effect. Further stratified analysis uncovered a more evident association with the risk of premature CAD among male subjects (C allele, OR = 1.65, and CC genotype, OR = 3.33).ConclusionsOur data provides the first evidence that APOC4 rs1132899 polymorphism was associated with an increased risk of premature CAD in Chinese subjects, and the association was more significant among male subjects.Electronic supplementary materialThe online version of this article (doi:10.1186/s12944-015-0065-7) contains supplementary material, which is available to authorized users.

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Prevention of coronary artery disease in men: Male hormone, female hormone, or both?

Cited by 5 publications

References 35 publications

The Ratio of Second to Fourth Digit Length (2D:4D) and Coronary Artery Disease in a Han Chinese Population

The Ratio of Second to Fourth Digit Length (2D:4D) and Coronary Artery Disease in a Han Chinese Population

Peer Review #1 of "Association of FKBP5 polymorphisms with patient susceptibility to coronary artery disease comorbid with depression (v0.1)"

The association of APOC4 polymorphisms with premature coronary artery disease in a Chinese Han population

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