Prevention of Coronary Restenosis

Casterella, Peter J.; Teirstein, Paul S.

doi:10.1097/00045415-199907000-00014

Cited by 57 publications

(46 citation statements)

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“…8 Furthermore, inflammatory and immune responses, as well as apoptotic processes have also been implicated [9][10][11] in the underlying disease mechanism. Our findings represent the first direct clinical-epidemiological evidence for the actual relevance of these mechanisms by highlighting molecular variants of seven genes that belong to the postulated pathogenic pathways (apolipoprotein CIII, cystathionine beta-synthase, monocyte differentiation antigen CD14, endothelial nitric oxide synthase 3, tumor suppressor protein p53, p53-associated protein, and tumor necrosis factor receptor type 1) and that we found to be significantly associated with the incidence of restenosis.…”

Section: Discussionmentioning

confidence: 99%

Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease

et al. 2002

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The complexity of recognizing the potential contribution of a number of possible predictors of complex disorders is increasingly challenging with the application of large-scale single nucleotide polymorphism (SNP) typing. In the search for putative genetic factors predisposing to coronary artery restenosis following balloon angioplasty, we determined genotypes for 94 SNPs representing 62 candidate genes, in a prospectively assembled cohort of 342 cases and 437 controls. Using a customized coupled-logistic regression procedure accounting for both additive and interactive effects, we identified seven SNPs in seven genes that, together, showed a statistically significant association with restenosis incidence (P Ͻ0.0001), accounting for 11.6% of overall variance observed. Among them are candidate genes for cardiovascular pathophysiology (apolipoprotein-species and NOS), inflammatory response (TNF receptor and CD14), and cell-cycle control (p53 and p53-associated protein). Our results emphasize the need to account for complex multi-gene influences and interactions when assessing the molecular pathology of multifactorial medical entities.

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Section: Discussionmentioning

confidence: 99%

Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease

et al. 2002

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“…In light of our finding that patients with the II genotype did not have a beneficial effect of the quinapril treatment, this favorable effect on restenosis was achieved by inhibition of the renin-angiotensin system. Given that multiple factors are associated with the development of neointimal hyperplasia, 6 sufficient protection from restenosis could not be obtained by the administration of an ACE inhibitor only. To our knowledge, the PARIS Study by Meurice et al is the only other published study on the effect of quinapril on in-stent restenosis.…”

Section: Control Groupmentioning

confidence: 99%

“…The mechanism by which restenosis occurs after coronary artery intervention may differ between conventional balloon angioplasty and intracoronary stent implantation. 12 In-stent restenosis results predominantly from neointimal hyperplasia consisting of smooth muscle cell migration and extracellular matrix formation, 6 not from late recoil. The present study was designed to evaluate the relationship between the effect of quinapril, a tissue-specific ACE inhibitor with high affinity 13 and an insertion/deletion (I/D) polymorphism of the ACE gene on the prevention of restenosis after coronary stent implantation.…”

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confidence: 99%

Quinapril Prevents Restenosis After Coronary Stenting in Patients With Angiotensin-Converting Enzyme D Allele.

Okumura

Sone

Kondo

et al. 2002

Circ J

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“…Placement of 32 P wires markedly reduced subsequent restenosis rates in a recently reported randomised controlled trial, and extensive investigation continues in this field. 1,2 In ophthalmology, the role of both external beam radiation and brachytherapy in the management of age-related macular degeneration (ARMD) and the role of beta radiation in trabeculectomy are currently under evaluation. It is therefore appropriate to revisit the role of beta radiation in ophthalmology.…”

Section: Introductionmentioning

confidence: 99%

Beta irradiation: new uses for an old treatment: a review

Kirwan¹,

Constable

Murdoch

et al. 2003

Eye

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Beta radiation has a long history as a treatment modality in ophthalmology. It is a convenient and practical method of applying radiation and has the advantage of minimal tissue penetration. There has been a recent resurgence in the use of beta radiation in other areas in medicine, such as the prevention of restenosis after coronary artery stenting. Beta radiation has been shown in vitro and in vivo to inhibit proliferation of human Tenon's fibroblasts, which enter a period of growth arrest but do not die. Effects on the cell cycle controller p53 have been shown to be important in this process.In ophthalmology, beta radiation has been used widely for the treatment of pterygium and is under evaluation for treatment of agerelated macular degeneration and for controlling wound healing after glaucoma drainage surgery. In this latter role, beta radiation may be particularly appropriate for use in developing countries to improve the results of trabeculectomy while potentially avoiding some of the side effects of other antimetabolites.

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Prevention of Coronary Restenosis

Cited by 57 publications

References 0 publications

Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease

Multi-locus interactions predict risk for post-PTCA restenosis: an approach to the genetic analysis of common complex disease

Quinapril Prevents Restenosis After Coronary Stenting in Patients With Angiotensin-Converting Enzyme D Allele.

Beta irradiation: new uses for an old treatment: a review

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