Prevention of Deep-Vein Thrombosis by Low-Dose Heparin in Patients Undergoing Total Hip Replacement

Morris, George K.; Henry, A.P.J.; Preston, B. J.

doi:10.1016/s0140-6736(74)91069-1

Cited by 86 publications

(42 citation statements)

References 14 publications

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“…The beneficial effect of such a combined prophy laxis seems to be due to an additive action of the medications. This is in agreement with the findings of Morris and Henry [14], where low dose heparin was used and combined with perioperative infusions of dextran which has an antiaggregating effect as well as ASL.…”

Section: Discussionsupporting

confidence: 92%

Combined Administration of Low Dose Heparin and Aspirin as Prophylaxis of Deep Vein Thrombosis after Hip Joint Surgery

Schöndorf¹,

Hey²

1976

Pathophysiol Haemos Thromb

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The study was carried out on 75 patients undergoing hip joint surgery. The efficacy of a prophylaxis of deep vein thrombosis (DVT) by acetylsalicylic lysine (ASL) and by a low dose heparin (LDH) combined with the ASL treatment was investigated using the ¹²⁵I-fibrinogen test. DVT was not significantly decreased by the ASL application (53%) compared to the controls (60%). DVT occurred significantly less under the combined administration (27 %) than in the other two groups.

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Section: Discussionsupporting

confidence: 92%

Combined Administration of Low Dose Heparin and Aspirin as Prophylaxis of Deep Vein Thrombosis after Hip Joint Surgery

Schöndorf¹,

Hey²

1976

Pathophysiol Haemos Thromb

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“…Its incidence after THR is reported to be as high as 70% without prophylaxis. [1][2][3][4][5][6][7] There are many reports concerning the aetiology and prophylaxis of DVT but surprisingly little is known about its natural history. Proximal thrombosis is an established cause of pulmonary embolism, but the importance of calf-vein thrombosis remains uncertain.…”

mentioning

confidence: 99%

Incidence and natural history of deep-vein thrombosis after total hip arthroplasty

Kim¹,

Oh²,

Kim³

2003

The Journal of Bone and Joint Surgery. British volume

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here are many reports concerning the aetiology and prophylaxis of deep-vein thrombosis (DVT) but little is known about its natural history. The purpose of our study was to identify the incidence and site of DVT, the risk factors for pulmonary embolism and the natural history of DVT after total hip replacement (THR) in patients who do not receive any form of prophylactic or therapeutic treatment for DVT.Two hundred patients who had a primary THR were included: 100 had one-staged bilateral THR and 100 had unilateral THR and 150 implants were cemented and 150 cementless. Coagulation assays, a full blood count, blood typing and serum chemical profile tests were performed for all patients on three separate occasions. Bilateral simultaneous or unilateral venograms were performed on the sixth or seventh postoperative day and perfusion lung scans preoperatively and on the seventh or eighth postoperative day. Further venograms were performed in all patients who had thrombi six months later.In the patients with bilateral THR, 52 (26%) venograms were positive for thrombi, while in the patients with unilateral THR 20 (20%) were positive (p = 0.89). In the patients with a cemented THR, 31 venograms (20.7%) were positive for thrombi, while in those with a cementless THR 41 (27.3%) were positive (p = 0.654). Further venograms in all 72 patients who had thrombi at six months after operation showed that they resolved completely and spontaneously regardless of their site and size. No patients had symptoms of pulmonary emboli and none were seen on the perfusion lung scans. Two patients died from unrelated causes. TAlthough the prevailing opinion is that patients with proximal venous thrombosis should be treated with anticoagulants, our study has shown that all thrombi regardless of their site and size resolve spontaneously without associated pulmonary embolism.

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“…Both methods have been used to diagnose thrombi after elective hip surgery and the reported total incidence of I2SI-fibrinogen test-detected thrombi has been of the same magnitude as thrombi detected with phlebograms, i.e. 40-50% (6,8,10,12,15,19) out of which a relatively high proportion (10-20% ) involve thrombi in the popliteal and femoral veins (8,10). In a previous study (22) we found DVT in 41% of patients after THR.…”

Section: Discussionmentioning

confidence: 74%

Clinical and Experimental Evaluation of the Thromboprophylactic Effect of Hydroxychloroquine Sulfate after Total Hip Replacement

Johansson¹,

Forsberg²,

Johnsson³

1981

Pathophysiol Haemos Thromb

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The rate of postoperative deep vein thrombosis was studied by the ¹²⁵I-fibrinogen method in 35 patients after total hip replacement. 12 out of 18 patients treated prophylactically with hydroxychloroquine sulfate developed deep vein thrombosis compared with 11 out of 17 patients in the control group. Platelet aggregability was inhibited in vitro by high concentrations of hydroxychloroquine sulfate, but these concentrations were not obtained in vivo and platelet aggregation was not inhibited in patients treated with hydroxychloroquine sulfate (Plaquenil®).

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Prevention of Deep-Vein Thrombosis by Low-Dose Heparin in Patients Undergoing Total Hip Replacement

Cited by 86 publications

References 14 publications

Combined Administration of Low Dose Heparin and Aspirin as Prophylaxis of Deep Vein Thrombosis after Hip Joint Surgery

Combined Administration of Low Dose Heparin and Aspirin as Prophylaxis of Deep Vein Thrombosis after Hip Joint Surgery

Incidence and natural history of deep-vein thrombosis after total hip arthroplasty

Clinical and Experimental Evaluation of the Thromboprophylactic Effect of Hydroxychloroquine Sulfate after Total Hip Replacement

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