1962
DOI: 10.1038/1961110a0
|View full text |Cite
|
Sign up to set email alerts
|

Prevention of Delayed Foreign Marrow Reaction in Lethally Irradiated Mice by Early Administration of Methotrexate

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
18
0
2

Year Published

1978
1978
2015
2015

Publication Types

Select...
3
3
2

Relationship

0
8

Authors

Journals

citations
Cited by 53 publications
(21 citation statements)
references
References 1 publication
1
18
0
2
Order By: Relevance
“…Numerous studies have investigated the influence of various interventions on incidence and severity of GVHD. Incidence is clearly re lated to histocompatibility [15,20,25], severity, as measured by survival, can be influenced by MTX [14,18,24,27]. A major problem confront ing human transplantation is that no assay is available which will predict the development of GVHD and therefore identify the patient who possi bly requires the most vigorous intervention with immunosuppression.…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…Numerous studies have investigated the influence of various interventions on incidence and severity of GVHD. Incidence is clearly re lated to histocompatibility [15,20,25], severity, as measured by survival, can be influenced by MTX [14,18,24,27]. A major problem confront ing human transplantation is that no assay is available which will predict the development of GVHD and therefore identify the patient who possi bly requires the most vigorous intervention with immunosuppression.…”
Section: Discussionmentioning
confidence: 99%
“…Matching of donor and recipient at the major histocompatibility locus re duces severity and incidence of GVHD in rodents, dogs and man [15,20,25]. Posttransplantation immunosuppression by drugs has been investi gated as an additional approach [5,16,21,25,29], Methotrexate (MTX) was shown to increase posttransplantation survival in mice and dogs [24,27] if given early after transplantation and on a prolonged schedule [14,18]. These studies led to the use of MTX as the posttransplantation im munosuppressive drug in human allogeneic bone marrow transplantation [25].…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Initial trials were limited to grafts from HLA-matched siblings, and most patients were children and young adults. Despite HLA matching and the use of postgrafting immunosuppression with methotrexate [19][20][21], approximately half of the patients developed acute GVHD. This observation stimulated further research in GVHD prevention in preclinical model systems.…”
Section: Current State Of the Art: Allogeneic Hematopoietic Cell Tranmentioning
confidence: 99%
“…Uphoff reported that in allogeneic transplants the severity of the immune reaction of donor cells against the host was controlled by genetic factors (93) . Also, Methotrexate (MTX), as an immunosuppressive agent, could prevent or ameliorate the graft-versushost (GVH) reaction (43,94) . In the 1960s, studies in canines provided important information about bone marrow transplantation (BMT) in outbred species applicable to humans.…”
Section: Early Studies In Animalsmentioning
confidence: 99%