2013
DOI: 10.1111/apha.12201
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Prevention of duodenal ileus reveals functional differences in the duodenal response to luminal hypertonicity in Sprague‐Dawley and Dark Agouti rats

Abstract: The duodenum possesses the ability to absorb fluid despite a very high luminal osmolality. Inhibition of cyclooxygenase-2 markedly enhanced the capability of the duodenum to secrete fluid and to decrease luminal osmolality, irrespective of the hyperosmolar solution or the rat strain used, and revealed notable differences between the two strains with regard to their osmolality-adjusting capability.

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Cited by 4 publications
(4 citation statements)
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References 26 publications
(52 reference statements)
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“…This state is called postoperative ileus, which is partly mediated by COX-2-derived intestinal prostacyclin. As such, administration of a selective COX-2 inhibitor can restore depressed intestinal functions, such as duodenal mucosal bicarbonate transport, permeability, motility, osmoregulation, and water transport [ 24 , 48 , 49 , 50 ]. In the present study, the selective COX-2 inhibitor parecoxib was used to enable investigations of physiological regulation of intestinal permeability.…”
Section: Discussionmentioning
confidence: 99%
“…This state is called postoperative ileus, which is partly mediated by COX-2-derived intestinal prostacyclin. As such, administration of a selective COX-2 inhibitor can restore depressed intestinal functions, such as duodenal mucosal bicarbonate transport, permeability, motility, osmoregulation, and water transport [ 24 , 48 , 49 , 50 ]. In the present study, the selective COX-2 inhibitor parecoxib was used to enable investigations of physiological regulation of intestinal permeability.…”
Section: Discussionmentioning
confidence: 99%
“…Pretreating rats with a selective COX-2 inhibitor, such as parecoxib, has been shown to restore normal intestinal physiology following laparotomy as the surgery itself causes postoperative intestinal paralysis, partly mediated by COX-2-derived intestinal prostacyclin [33]. The paralysis attenuates intestinal functions, such as motility, alkaline secretion, osmoregulation, and water transport, which may all affect the relevance of the data [34]. Furthermore, parecoxib has been previously shown to have no effect on basal intestinal permeability in rats [35] and had no effect on SDS-induced epithelial injury in our present study.…”
Section: Discussionmentioning
confidence: 99%
“…Initially, the three-part perfusion experiment was performed with and without pretreatment of the rats with parecoxib (a selective COX-2 inhibitor) to evaluate the basal SDS effect on jejunal permeability. All other groups were pretreated with parecoxib as it restores physiologic enteric nerve activity after abdominal surgery [ 34 , 35 ]. Thirty minutes into the 45 min control period (15 min before the start of the luminal SDS perfusion), either melatonin (100 μM) or misoprostol (10 μM) or melatonin (100 μM) plus misoprostol (10 μM) were added to the perfusate solutions.…”
Section: Methodsmentioning
confidence: 99%
“…These are all important components in both the development and treatment of mucosal barrier dysfunction. However, laparotomic surgery performed in the SPIP model preparation causes postoperative ileus, which influences normal physiological GI functions such as permeability, osmoregulation and motility [ 48 , 49 ]. In this study, we therefore pretreated all rats with a selective COX-2 inhibitor [ 50 ] as this restores the GI functions affected by surgery [ 49 ].…”
Section: Discussionmentioning
confidence: 99%