Prevention of enamel demineralization during orthodontic treatment: An in vitro comparative study

Bichu, Yashodhan M; Kamat, Nandini V; Chandra, Pavan Kumar; Kapoor, Aditi; Aravind, N K S

doi:10.11607/ortho.870

Cited by 10 publications

(8 citation statements)

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“…Hamba et al 22 reported minimum loss of minerals and shallowest lesions in the fluoride group compared to CPP-ACP and CPP-ACP-F. 22 The preventive effects of CPP-ACP, MI Paste Plus, fluoride varnish and sodium-calcium-phosphosilicate were compared in another study and it was found that fluoride varnish was the most effective of all. 21 Another study confirmed the optimal efficacy of fluoride for prevention of WSLs. 27 Several clinical and in vitro studies have documented that fluoride-containing products have the greatest remineralizing effect compared to other products.…”

Section: Discussionmentioning

confidence: 87%

“…However, in some previous studies, MI Paste Plus significantly inhibited the formation of enamel lesions, although its efficacy was still lower than that of fluoride in this respect. 21-23 This controversy in the results might be attributed to differences in methods of assessment of samples since we only measured the surface microhardness using a Vickers microhardness tester while previous studies used polarized light microscope and micro-computed tomography for precise quantification of mineral loss and measurement of depth of lesions. 21,23…”

Section: Discussionmentioning

confidence: 99%

“…Several methods have been used to assess the degree of remineralization of samples, including DIAGNOdent, 13 quantitative light-induced fluorescence (QLF), scanning electron microscopy, 19 polarized light microscope, 20-21 x-ray spectrophotometer, 9 standard photography, 4 micro-computed tomography 22 and transverse micro-radiography. 23…”

Section: Discussionmentioning

confidence: 99%

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Prevention of white spot lesions using three remineralizing agents: An in vitro comparative study

Tahmasbi

Mousavi

Behroozibakhsh

et al. 2019

J Dent Res Dent Clin Dent Prospects

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Background. Enamel demineralization around orthodontic brackets is an important clinical problem. This study sought to compare the efficacy of sodium fluoride (NaF), casein phosphopeptide amorphous calcium phosphate fluoride (CPP-ACP-F; MI Paste Plus) and a water-based cream (Remin Pro), which contains hydroxyapatite and fluoride for prevention of enamel demineralization. Methods. Fifty-six sound human premolars extracted for orthodontic purposes were collected. After cleaning, the crowns were mounted in acrylic resin and all the surfaces were coated with nail varnish except for a 3×4-mm window on the buccal surface. The samples were randomly divided into four groups of 14 and subjected to pH cycling for 14 days, during which the teeth were immersed in artificial saliva for 21 hours and in demineralizing agent for three hours daily. Before transferring the samples from the saliva to the demineralizing solution, the remineralizing agent (0.05% NaF, MI Paste Plus or Remin Pro Paste, depending on the group) was applied on the samples once a day for five minutes. No remineralizing agent was used in the control group. Surface microhardness of samples was measured by Vickers microhardness tester at baseline and after the intervention. The data were analyzed using one-way ANOVA, ANCOVA, Bonferroni test and Tukey test. Statistical significance was set at P<0.05. Results. The mean microhardness was significantly different between the test and control groups (P<0.0001). Other differences were not significantly different (P>0.05). Conclusion. The results showed that 0.05% NaF was more efficient than Remin Pro and MI Paste Plus for prevention of white spot lesions (WSLs). Remin Pro and MI Paste Plus were not significantly difference from the control group in this regard.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 99%

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Prevention of white spot lesions using three remineralizing agents: An in vitro comparative study

Tahmasbi

Mousavi

Behroozibakhsh

et al. 2019

J Dent Res Dent Clin Dent Prospects

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“…27 Conversion of carbonic acid into water and carbon dioxide should occur before any of these circumstances undergoes alterations. [28][29][30]…”

Section: Concept Of Remineralizationmentioning

confidence: 99%

Is there evidence for Novamin application in remineralization?: A Systematic review

Khijmatgar

Reddy

John³

et al. 2020

Journal of Oral Biology and Craniofacial Research

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Background: Calcium sodium phosphor-silicate material, a type of bio-glass was originally developed as an implant material to regenerate bone and recently adapted for use in oral care products (NovaMin Technology Inc.). Novamin is used for many dental problems like hypersensitivity, gingivitis, bleeding, non-carious lesions, carious lesions, whitening and is currently emerging as one of the treatment modality for the remineralization of the tooth. Since the prescription of these novel materials to the patients are based on cost effectiveness, efficacy and effectiveness, a clinician should make decision based on best available evidence. Hence, the objective of this review is to find out the current evidence available on the use of Novamin as an agent for remineralization. Materials and methods: Relevant articles were searched and screened from several databases including PubMed, Cochrane review, Science Direct and trip which were published till 1988 to July 2017; The articles relevant to the objective of this review were included (RCT's) and articles out of interest of this review were excluded. The primary outcome for the chosen studies is the remineralization capacity of Novamin. Data extraction is done independently and jointly by 3 authors using data collection forms. Studies obtained were evaluated using the Cochrane Collaboration tools for accessing risk bias. The assessment of the quality of the evidence and the bias risk was obtained using the Grading of Recommendations Assessment Development and evaluation System. Results: The articles from the database obtained for further review was N = 1. According to the study reviewed, the baseline comparisons using decalcification index obtained between Novamin study group (ReNew) and the control group (Crest) yield a P-value of 0.97 whereas after a 3 months interval follow up the value is 0.0403 suggesting there was a trend towards improvement in white spot lesions in the control group and at 6 months' time point the p-value is 0.81 concluding that there are no significant difference of remineralization process obtained by using traditional toothpaste and Novamin. Conclusion: Review shows that Novamin has significantly less clinical evidence to prove its effectiveness as a remineralization agent in treating both carious and non-carious lesion. Hence, better designed clinical trials should be carried out in the future before definitive recommendations can be made.

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“…The description of each study is provided in Appendix II. In total, 15 articles [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] were excluded, six [20][21][22][23][24][25] because the experimental design used artificial lesions in vitro, two 26,27 because there was no comparison of a remineralising intervention against a control. The participants of one study 28 had not undergone orthodontic treatment, one study 29 did not include statistical data in the results section and was therefore excluded since a meta-analysis or comparison of results could not be performed.…”

Section: Study Characteristicsmentioning

confidence: 99%

Clinical evidence in the treatment of white spot lesions following fixed orthodontic therapy: a meta-analysis

Yeoh

Maravilla

et al. 2018

Australasian Orthodontic Journal

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Objective This systematic review aims to determine the most effective method of treatment to remineralise post-orthodontic white spot lesions (WSLs). Method Six databases were accessed and searched for articles. Screening and selection were conducted according to the PRISMA guidelines using predetermined inclusion and exclusion criteria. Two reviewers independently assessed and extracted identified studies and relevance disagreement was resolved through consensus. Experimental studies were included that involved (i) patients of any age who had WSLs after the removal of fixed appliances, (ii) any treatment to remineralise the WSLs compared with no treatment or a placebo, and (iii) measurement of the changes in enamel mineralisation status after treatment. Eligible articles were assessed for internal bias and underwent narrative synthesis. A meta-analysis using random-effects modelling was performed to calculate a pooled estimate and assess between-study variability using Cochran’s Q and I2. Results The nine articles included in this review were found to have a medium or high risk of bias. The qualitative assessment provided contrasting results between studies. The meta-analysis showed both CPP-ACP – pooled d of -0.28 (N = 5 studies; 95% CI = -0.48- -0.07) – and fluoride – pooled d of -0.25 (N = 4 studies; 95% CI = -0.48- -0.02) – to generate improvement in the enamel mineralisation status, with CPP-ACP producing more consistent results compared with fluoride. Conclusions The meta-analysis found that CPP-ACP and fluoride were effective in reducing post-orthodontic WSLs. Due to the heterogeneity of the included studies with regard to the fluoride concentrations and mode of delivery, the current meta-analysis could not accurately establish which remineralising agent, CPP-APP or fluoride, is more effective. Further high quality studies of long-term duration are required to determine best clinical practice.

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Prevention of enamel demineralization during orthodontic treatment: An in vitro comparative study

Abstract: The use of these commercially available medicaments could prove to be beneficial for patients undergoing orthodontic treatment and who are at a risk for developing enamel decalcification.

Cited by 10 publications

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Prevention of white spot lesions using three remineralizing agents: An in vitro comparative study

Prevention of white spot lesions using three remineralizing agents: An in vitro comparative study

Is there evidence for Novamin application in remineralization?: A Systematic review

Clinical evidence in the treatment of white spot lesions following fixed orthodontic therapy: a meta-analysis

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Prevention of enamel demineralization during orthodontic treatment: An in vitro comparative study

Abstract: The use of these commercially available medicaments could prove to be beneficial for patients undergoing orthodontic treatment and who are at a risk for developing enamel decalcification.

Cited by 10 publications

References 0 publications

Prevention of white spot lesions using three remineralizing agents: An in vitro comparative study

Prevention of white spot lesions using three remineralizing agents: An in vitro comparative study

Is there evidence for Novamin application in remineralization?: A Systematic review

Clinical evidence in the treatment of white spot lesions following fixed orthodontic therapy: a meta-analysis

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Prevention of enamel demineralization during orthodontic treatment: An in vitro comparative study