Prevention of experimental stroke by hypercapnic-hypoxic preconditioning

Abstract

The effectiveness of hypercapnic hypoxic training in the prevention of acute disturbances in cerebral circulation was studied under experimental conditions. Hypercapnic hypoxic training was followed by a significant decrease in the severity of neurological deficit and locomotor and coordination disorders after cerebral ischemic injury.

Tolerance to acute hypoxia maximally increases in case of joint effect of normobaric hypoxia and permissive hypercapnia in rats

“…Previously, we observed a significant protective effect of hypercapnic hypoxia (HcH) in cerebral ischemia [25]. However, we did not find any research concerning the comparative efficacy of isolated and joint effects of hypercapnia and hypoxia in increasing the tolerance of an organism to acute hypoxia.…”

“…Such parameters of hypoxic exposure were chosen because of their high effectiveness in combination with permissive hypercapnia (PCO 2 of 50 mmHg) in preventing experimental stroke in rats [25].…”