“…Increasing evidence indicates that HPI may play a role in the complex and multifactorial nature of falls. Because OP is only part of the fracture equation, of particular importance is the fact that many mentioned above HPI-associated chronic diseases and their various combinations affect simultaneously (directly and/or indirectly) bone homeostasis and muscle mass/function, altering mobility, gait and balance, causing hemodynamic instability and collectively elevating the risk of falls and fractures, especially in the elderly [ 451 , 452 , 453 , 454 , 455 , 456 , 457 , 458 , 459 , 460 , 461 , 462 , 463 , 464 , 465 ]. It has been estimated that 87% of all fractures in the elderly are the result of a fall and 5–10% of all falls result in a fracture [ 466 , 467 , 468 ].…”