Prevention of grafted liver from reperfusive injury

Ma, Kai; Yu, Yang; Bu, Xianmin; Li, Yanjun; Dai, Xian-Wei; Wang, Liang; Yang, Dai Chang; Zhao, Haiying

doi:10.3748/wjg.v7.i4.572

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…IP has a significant protective effect on IRI of transplanted liver, but the underlying mechanism remains unclear. The protective mechanisms are thought to be associated with elevated adenosine and nitric oxide levels, tumor necrosis factor-a elimination, and changes in energy metabolism and maintenance of microcirculation (Ma et al, 2001;Zhang and Chen, 2004;Lee and Lee, 2006).…”

Section: Possible Mechanisms Of the Protective Effect Of Ip On The Domentioning

confidence: 99%

Protective effect of ischemia preconditioning on ischemia-reperfusion injury in rat liver transplantation

Qing¹,

Zhang²,

Gao³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We explored the protective effect of ischemia preconditioning (IP) on ischemia-reperfusion injury in rat liver transplantation. An orthotopic liver transplantation model was utilized in the study. A total of 54 Sprague-Dawley rats were divided into a control group (group A, no liver transplantation), liver transplantation group (group B, heparin Ringer's lactate solution was perfused via the portal vein before donor liver collection), and liver transplantation with IP group (group C, IP was performed for different time periods before donor liver collection). Liver function, B-cell lymphoma 2 expression in hepatic cells, cell apoptosis, and cellular ultrastructure changes were detected after surgery. After surgery, serum alanine aminotransferase activity was significantly higher in group B than in group A, while it was not clearly enhanced in group C and decreased progressively with increasing cycles of IP as bile capacity gradually increased. Compared 3019 Protective effect of ischemia preconditioning ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 3018-3025 (2015) with group B, group C showed alleviated injury of hepatic cells, increased B-cell lymphoma 2 expression, and a lower apoptosis index. IP had a protective effect on ischemia-reperfusion injury in rat liver transplantation, and the mechanism correlated with increased B-cell lymphoma 2 expression in hepatic cells and inhibition of cell apoptosis.

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Section: Possible Mechanisms Of the Protective Effect Of Ip On The Domentioning

confidence: 99%