Prevention of Hemorrhagic Pancreatitis With Fibrinolysin or Heparin

Applicability of Disseminated Intravascular Coagulation Parameters in the Assessment of the Severity of Acute Pancreatitis

“…[29][30][31][32][33] Gabryelewics et al 29 has long advocated the use of heparin in patients with acute pancreatitis, but this is not usually done because of the possible danger of hemorrhagic pancreatitis. [29][30][31][32][33] Gabryelewics et al 29 has long advocated the use of heparin in patients with acute pancreatitis, but this is not usually done because of the possible danger of hemorrhagic pancreatitis.…”

Disturbances of the microcirculation in acute pancreatitis

“…Histological changes in animal pancreatitis parallel findings in humans. Microscopy demonstrates vessel wall media necrosis, with infiltration of polymorphonuclear leucocytes73, 89, increased fenestration, micropinocytic vesicles and irregularity of the endothelial lining90. Outside the capillary bed, the histology and architecture of vessels remains unchanged88.…”

Towards a Novel Treatment Strategy for Acute Pancreatitis

“…Table 2 lists measures that have been beneficial when instituted once acute pancreatitis is under way and shows that the common denominator is the control of mast cell pathology [9, 28, 29, 57, 71, 73, 74, 75, 76, 77, 78, 79, 80, 81, 82, 83, 84, 85, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98]. Since impedance to exocytosis in the acinar cell is the detonating event and this is best explained by oxidant-induced interruption to the flow of methyl groups [1], it is logical to regard the resumption of that flow as the reason why re-feeding with methionine [73]or treatment with an analogue of ascorbate [74]– which facilitates the recycling of methyl groups from homocysteine via the folate-vitamin B 12 shuttle – ameliorate in the choline-deficient ethionine-supplemented (CDE) dietary model of severe disease.…”

“…The beneficial properties of heparin – over and above its anticoagulant effect – have been enumerated [1, 2, 28, 29, 95, 98]. In respect of anticoagulant and anti-inflammatory properties, native heparin is said to be more efficacious than synthetic products and full-dose better than low-dose regimens.…”