Prevention of Hepatic Artery Occlusion During Continuous Infusion of Fluorouracil Using Liposteroid

Hepatic arterial infusion alternating with systemic chemotherapy in patients with non‐resectable hepatic metastases from colorectal cancer

“…In the present study, three patients experienced catheter occlusion prohibiting further HAI chemotherapy despite regular heparin injection through the port. One previous study suggested that liposteroids, such as dexamethasone palmitate, have a preventive effect on hepatic artery stenosis, at least in the short term 23 . Although meta‐analysis confirms the cost‐effectiveness of HAI chemotherapy, 24 the cost of this treatment was a burden for some of the patients in the present study.…”

Hepatic arterial infusion plus systemic chemotherapy as third-line or later treatment in colorectal liver metastases

“…Although HAI yielded a significant tumor response rate for liver metastatic lesions, more than half of patients eventually displayed extrahepatic recurrence [19]. Clearly, HAI alone could not guarantee therapeutic activity against clinically occult extrahepatic disease.…”

Short Review of Liposteroid: A Novel Targeted Glucocorticoid Preparation for Treatment of Autoimmune and Inflammatory Diseases

“…Liposteroid also possesses protective effects on the vascular endothelium (Suzuki et al, 1992). Sadahiro et al (2000) reported an exciting application of liposteroid therapy. The authors utilized liposteroid for the prevention of hepatic artery stenosis due to hepatic arterial infusion of chemotherapeutic drugs for liver metastasis in patients with colorectal cancer (Sadahiro et al, 2000).…”

“…Sadahiro et al (2000) reported an exciting application of liposteroid therapy. The authors utilized liposteroid for the prevention of hepatic artery stenosis due to hepatic arterial infusion of chemotherapeutic drugs for liver metastasis in patients with colorectal cancer (Sadahiro et al, 2000). In their study, when liposteroid was simultaneously infused with 5-fluorouracil, none of the 12 patients developed hepatic artery stenosis.…”