Prevention of Hypertension and Cardiovascular Diseases

Kokubo, Yoshihiro

doi:10.1161/hypertensionaha.113.00543

Cited by 58 publications

(16 citation statements)

References 75 publications

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“…This finding indicated the potential of SQ as an alternative treatment for hyperlipidemia and high blood pressure, thus preventing the occurrence of CVD [51]. Both high blood pressure and hyperlipidemia are among the most important risk factors for CVD [84].…”

Section: Animal Studies Related To Hyperlipidemiamentioning

confidence: 96%

The Efficacy of Squalene in Cardiovascular Disease Risk-A Systematic Review

et al. 2020

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Introduction: Cardiovascular disease (CVD) is the leading cause of death worldwide. Squalene (SQ), an intermediate for the cholesterol biosynthesis, has been proposed to act similarly to statins via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase in the liver. Purpose: This paper explores the effects of SQ in CVD. Methods: A systematic review of the literature was performed to identify relevant studies about SQ and CVD. A comprehensive search in Medline and Scopus for relevant studies published between the years 1946 and 2019 was performed. The main inclusion criteria were that the study was published in English; that the study reported association or effect of SQ and CVD; and that CVD should be related to lifestyle variables, aging, or experimentally induced conditions. Results: The literature searches identified 5562 potentially relevant articles, whereby 21 studies met the inclusion criteria. There were three human studies and 18 animal experimental studies included in this paper. Only one human study reported positive outcome of SQ in CVD. The remaining two studies reported inconsistent and/or no effect. For animal studies, 15 studies reported positive effect while the remaining reported negative and/or no effect of SQ on various related parameters. Conclusions: This evidence-based review emphasizes the potential of SQ being used for cardiovascular-related diseases. The effect of SQ, especially of plant-based warrants further exploration. Controlled human observational studies should be performed to provide comprehensive evidence.

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Section: Animal Studies Related To Hyperlipidemiamentioning

confidence: 96%

The Efficacy of Squalene in Cardiovascular Disease Risk-A Systematic Review

et al. 2020

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“…Хронічна ішемія мозку займає провідні позиції у структурі причин інвалідизації населення у нашій країні та у всьому світі [1]. Одним із найбільш значущих судинних факторів ризику (СФР) церебро-васкулярної патології є артеріальна гіпертензія (АГ), для якої характерним є переважне поступове ураження дрібних судин головного мозку, результатом чого є дрібно вогнище дифузне ураження головного мозку і навіть розвиток німих інфарктів [2,3].…”

Section: вступunclassified

The study of heart rhythm variability in patients with primary manifestations of chronic cerebral ischemia

Тріщинська¹

2016

ScienceRise: Medical Science

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“…In this regard, the interaction between UAE and GFR may be different between them, because salt intake and its sensitivity is higher in the East Asian population. 11 The Watari study is a prospective cohort study that began in 2009 to examine the prognostic significance of albuminuria for the prediction of cardiovascular events. 12 , 13 , 14 The aim of this study was to use this population to examine whether or not a subtle increase in UAE within the normal range could be a risk factor for incident hypertension and if so, to determine how the risk is modified according to estimated GFR (eGFR).…”

Section: Introductionmentioning

confidence: 99%

Relationship between subtle urinary albumin excretion and risk of incident hypertension: modification by glomerular filtration rate

2017

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It has been reported that an increase in urinary albumin excretion (UAE) within the normal range could be a risk factor for incident hypertension. However, it remains unclear how the subtle increases in UAE and renal function interact in the development of hypertension. We examined the modification of UAE as a risk factor for incident hypertension by glomerular filtration rate (GFR) in the Japanese population. We prospectively followed 1281 normotensive individuals from Watari town (34.3% men; mean age, 58.0±12.3 years old) whose UAE was <30 mg g−1· Cr. Hypertension was diagnosed as a systolic blood pressure (BP)⩾140 mm Hg and/or a diastolic BP⩾90 mm Hg, or antihypertensive medication use. The relationship between sex-specific quartiles of UAE and incident hypertension was examined with Cox proportional hazard analysis. During a mean follow-up of 3.7 years, 315 individuals developed hypertension. Multivariate Cox proportional hazard analysis revealed that a subtle increase in UAE was a risk factor for incident hypertension, but there was a significant interaction between UAE and estimated GFR (eGFR) (P=0.018). The risk of incident hypertension dose dependently increased in the highest eGFR quartile (⩾90 ml min−1 per 1.73 m2). Decline in renal function alone increased the risk of incident hypertension but the increased risk with a subtle increase in UAE became smaller and less clear in the lower eGFR quartiles. The present data suggest that UAE as a risk factor for incident hypertension is largely dependent on eGFR levels.

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Prevention of Hypertension and Cardiovascular Diseases

Cited by 58 publications

References 75 publications

The Efficacy of Squalene in Cardiovascular Disease Risk-A Systematic Review

The Efficacy of Squalene in Cardiovascular Disease Risk-A Systematic Review

The study of heart rhythm variability in patients with primary manifestations of chronic cerebral ischemia

Relationship between subtle urinary albumin excretion and risk of incident hypertension: modification by glomerular filtration rate

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