Prevention of Hypertension, Cardiovascular Damage and Endothelial Dysfunction with Green Tea Extracts

Antonello, Michele; Montemurro, Domenico; Bolognesi, Massimo; Pascoli, Marco Di; Piva, Adrián; Grego, Franco; Sticchi, Daniele; Giuliani, Luisa; Garbisa, Spiridione; Rossi, Gian Paolo

doi:10.1016/j.amjhyper.2007.08.006

Cited by 79 publications

(43 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Green tea has been found to reduce plasma concentrations of oxidized LDL, 10,26 which may promote atheroma formation by increasing macrophage uptake, 27 monocyte recruitment 28 and direct endothelial cell damage. 29 Apart from the antioxidant and lipid-lowering effects, many other mechanisms may be responsible for the protective effects of green tea in the process of atherogenesis, which include a beneficial effect on hypertension, 11,12 improvement of hemorheological abnormalities, 13 inhibition of platelet aggregation 14,15 and improvement of endothelial function, 16,17 which plays an important role in the first step toward coronary arteriosclerosis. 30 Few studies conducted in Japan have reported the relationship between green tea consumption and angiographically proven CAD.…”

Section: Discussionmentioning

confidence: 99%

“…4,5 However, another study has failed to show that green tea has protective effects. 6 The potential protective effect of green tea and tea constituents from CAD may be due to lipid-lowering, 7,8 antioxidative, 9,10 antihypertensive, 11,12 hemorheological abnormality-improving, 13 antithrombogenic 14,15 and vasculoprotective 16,17 activities. To our knowledge, until now there has not been any studies that have evaluated the relationship between green tea consumption and angiographically proven CAD in China.…”

Section: Editorial P 248mentioning

confidence: 99%

See 1 more Smart Citation

Association Between Green Tea Intake and Coronary Artery Disease in a Chinese Population

Wang

Gong

Yan

et al. 2010

Circ J

View full text Add to dashboard Cite

Background: There is still conflicting evidence that green tea may protect against coronary atherosclerosis therefore the present study investigated the association between green tea consumption and arteriographically determined coronary atherosclerosis in a Chinese population. Methods and Results:The study population consisted of 520 consecutive patients (379 men and 141 women) who underwent coronary arteriography for the first time. Patients were divided into 2 groups (Non-coronary artery disease [CAD] and CAD groups) according to the results of coronary arteriography. After adjusting the established and potential confounders, green tea consumption was associated with a reduced risk of CAD in male patients, with an adjusted odds ratio (OR) of 0.62 (95% confidence interval, 0.38-1.01) compared with those who did not drink green tea. Compared to non-tea drinkers, the adjusted ORs were 1.09 (0.61-1.96) in male patients consuming less than 125 g of dried green tea leaves per month, 0.36 (0.19-0.71) for 125-249 g per month and 0.36 (0.17-0.73) for ≥250 g per month, with a statistically significant test for trend (P<0.001). Similar dose-response relationships were also observed for frequency, duration, concentration and starting age of green tea drinking in male patients. In female patients, no inverse association was found between green tea consumption and CAD. Conclusions:Green tea consumption can protect against the development of coronary atherosclerosis in Chinese male patients. (Circ J 2010; 74: 294 - 300)

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Editorial P 248mentioning

confidence: 99%

Association Between Green Tea Intake and Coronary Artery Disease in a Chinese Population

Wang

Gong

Yan

et al. 2010

Circ J

View full text Add to dashboard Cite

show abstract

“…Two different techniques, which overall provide similar results, were used at the 2 participating centers. Arteries were investigated with the pressurized myography at the University of Padua 18 and with the wire myograph (410 A, Danish Myo-Technology) at the University of Brescia, as described. 10,12 For more details please see the data supplement.…”

Section: Evaluation Of Small Artery Structurementioning

confidence: 99%

Vascular Remodeling and Duration of Hypertension Predict Outcome of Adrenalectomy in Primary Aldosteronism Patients

et al. 2008

View full text Add to dashboard Cite

Abstract-Remodeling of the resistance arteries is a hallmark of arterial hypertension and predicts cardiovascular events, but it was unknown whether it could also predict the blood pressure response to adrenalectomy of patients with an aldosterone-producing adenoma. Therefore, we investigated the outcome of adrenalectomy as a function of vascular remodeling in the context of the preoperative features of aldosterone-producing adenoma patients. At 2 referral centers for hypertension, we prospectively measured the media:lumen ratio of small arteries from fat tissue of 50 consecutive aldosterone-producing adenoma patients treated with adrenalectomy. The blood pressure response to adrenalectomy was assessed by considering the blood pressure values and the number and dosages of antihypertensive medications. Adrenalectomy significantly (PϽ0.001) lowered plasma aldosterone (from 27.3Ϯ4.9 ng/dL to 8.3Ϯ11.2 ng/dL), the aldosterone:renin ratio (from 117Ϯ35 to 11Ϯ2), and blood pressure (from 163Ϯ22/98Ϯ2 mm Hg to 133Ϯ2/ 84Ϯ1 mm Hg), even despite a reduction (from 141Ϯ14 to 100Ϯ15; Pϭ0.02) of the score of antihypertensive treatment.It provided cure of hypertension in 30% of the aldosterone-producing adenoma patients, normotension with less antihypertensive therapy in 52%, and improved blood pressure control in the rest. The media:lumen ratio and the known duration of hypertension significantly predicted the blood pressure response to adrenalectomy at univariate and multivariate analyses. Because a long duration of hypertension and/or the presence of vascular remodeling imply lower chances of blood pressure normalization at long-term follow-up postadrenalectomy, these findings emphasize the importance of an early diagnosis of aldosterone-producing adenoma. Key Words: secondary hypertension Ⅲ aldosterone Ⅲ aldosteronism Ⅲ adrenalectomy Ⅲ outcome Ⅲ vascular remodeling P rimary aldosteronism (PA) is far more common than usually perceived and is attributable to an aldosteroneproducing adenoma (APA) in approximately half of the patients. 1 Thus, it entails the most common endocrine form of secondary arterial hypertension (HT) that is curable by adrenalectomy in many patients. 2 Identification of an APA, or unilateral primary adrenocortical hyperplasia, 3 requires adrenal vein sampling (AVS) that, being minimally risky, should be reserved for patients who are candidates for adrenalectomy and, more importantly, can benefit from it. 4 However, the identification of patients who will benefit more remains a challenging task, because the blood pressure (BP) response to adrenalectomy varies widely across patients. In fact, despite many efforts over the years, only age and lack of family history of HT were suggested to significantly predict the BP response. 5-8 Nevertheless, the large uncertainties in the prediction estimates render them of little, if any, 8 value on an individual basis.The remodeling of resistance arteries is a hallmark of arterial HT and can be implicated in the excess cardiovascular damage associated with HT. Hence, it ...

show abstract

“…Hence, as depicted in Figure 2, one or more genetic and/or environmental factors affecting the pathways through which aldosterone induces vasoconstriction or Na + and water retention can have an impact on the final phenotype BP in PA, as recently discussed. 6 For example, a low Na + intake and/or a high consumption of green tea, which lowers BP, 8 can mask the BP-raising effect of aldosterone, although this was unfortunately not assessed by Ito et al 2 Nonetheless, the occurrence of these interactions is best supported by the fact that normotensive PA has been documented in two patients with Bartter-Gitelman syndrome, a condition usually associated with Na + wasting and low BP. 9 …”

Section: Why Can Patients With Pa Be Normotensive or Only Mildly Hypementioning

confidence: 87%

Does primary aldosteronism exist in normotensive and mildly hypertensive patients, and should we look for it?

Rossi

2010

Hypertens Res

View full text Add to dashboard Cite

Prevention of Hypertension, Cardiovascular Damage and Endothelial Dysfunction with Green Tea Extracts

Abstract: The GTE prevented hypertension and target organ damage induced by a high Ang II dose, likely by prevention or scavenging of superoxide anion generation.

Cited by 79 publications

References 29 publications

Association Between Green Tea Intake and Coronary Artery Disease in a Chinese Population

Association Between Green Tea Intake and Coronary Artery Disease in a Chinese Population

Vascular Remodeling and Duration of Hypertension Predict Outcome of Adrenalectomy in Primary Aldosteronism Patients

Does primary aldosteronism exist in normotensive and mildly hypertensive patients, and should we look for it?

Contact Info

Product

Resources

About