Prevention of melatonin suppression by nocturnal lighting: relevance to cancer

Kayumov, Leonid; Lowe, Alan D.; Rahman, Shadab A.; Casper, Robert F.; Shapiro, Colin M.

doi:10.1097/01.cej.0000215622.59122.d4

Cited by 26 publications

(10 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The dark eye color of Chinese women may prevent the suppression of melatonin secretion from nocturnal light. This hypothesis is supported by two recent studies mentioned by Girschik et al [31] in their letter discussing the findings by Pronk et al In a small intervention study (n=11) light-filtering goggles’ were effective in preventing the suppression of melatonin by nocturnal lighting in Caucasians but not Asian men [32]. In another study comparing the influence of eye colors of Caucasians and Asian on suppression of melatonin secretion by light, two groups of subjects were exposed to light (1000 lux) for 2 hours at night, and suppression of melatonin by light was found to be significantly stronger for Caucasians (88.9 +/− 4.2%) than for Asians (73.4 +/− 20.0%) [33].…”

Section: Discussionmentioning

confidence: 58%

Shift work and breast cancer among women textile workers in Shanghai, China

Ray

Thomas

et al. 2014

Cancer Causes Control

View full text Add to dashboard Cite

PURPOSE Although night shift work has been associated with elevated risk of breast cancer in numerous epidemiologic studies, evidence is not consistent. We conducted a nested case-cohort study to investigate a possible association between shift work including a night shift and risk of breast cancer within a large cohort of women textile workers in Shanghai, China. METHODS The study included 1709 incident breast cancer cases and 4780 non-cases. Data on historical shift-work schedules were collected by categorized jobs from the factories where the study subjects had worked, and then were linked to the complete work histories of each subject. No jobs in the factories involved exclusively night shift work. Therefore, night shift was evaluated as part of a rotating shift work pattern. Hazard ratios and 95% confidence intervals were calculated using Cox proportional hazards modeling adapted for the case-cohort design for years of night-shift work and the total number of nights worked. Additionally, analyses were repeated with exposures lagged by 10 and 20 years. RESULTS We observed no associations with either years of night-shift work, or number of nights worked during the entire employment period, irrespective of lag intervals. Findings from the age-stratified analyses were very similar to those observed for the entire study population. CONCLUSIONS The findings from this study provide no evidence to support the hypothesis that shift work increases breast cancer risk. The positive association between shift work and breast cancer observed in Western populations, but not observed in this and other studies of the Chinese population, suggest that the effect of shift work on breast cancer risk may be different in Asian and Caucasian women.

show abstract

Section: Discussionmentioning

confidence: 58%

Shift work and breast cancer among women textile workers in Shanghai, China

Ray

Thomas

et al. 2014

Cancer Causes Control

View full text Add to dashboard Cite

show abstract

“…High correlated color temperature light has a larger blue light component compared with low correlated color temperature light. In another study, in which filters were used to selectively exclude certain wavelengths, participants had normal melatonin secretion when wavelengths below 530 nm were excluded and exhibited drastically suppressed melatonin production under unfiltered bright light …”

Section: Discussionmentioning

confidence: 99%

Effects of television luminance and wavelength at habitual bedtime on melatonin and cortisol secretion in humans

Komada

Aoki

Gohshi

et al. 2015

Sleep and Biological Rhythms

View full text Add to dashboard Cite

The aim of this study was to examine the effect of exposure to different types of television displays at habitual bedtime on human melatonin and cortisol secretion. Thirteen male participants (mean age: 22.7 ± 0.85 years) were tested over three nights in one baseline and two experimental sessions. Participants were instructed to watch a movie on four different luminance-and wavelengthcontrolled television displays: normal luminance (450 candela [cd]/m 2 ) or high luminance (1200 cd/ m 2 ) and normal blue light or half blue light. Salivary melatonin and cortisol levels were measured at two time points before and after television viewing. There was no significant difference in cortisol secretion due to the different displays. Melatonin suppression was significantly lower following the exposure to the half-blue light display compared with the normal blue light display. These results suggest that the use of half-blue light displays during night time may prevent circadian rhythm dysfunction.

show abstract

“…We and others have demonstrated previously that exposure at night to polychromatic white light from which short-wavelength light (Ͻ530 nm) has been filtered prevents melatonin suppression in humans (28,29,52). The present study extended these findings, demonstrating that completely filtering short wavelengths Ͻ480 nm from nocturnal light not only attenuates the suppression of melatonin but also prevents alterations in cortisol secretion and clock gene expression in humans.…”

Section: Discussionmentioning

confidence: 99%

Spectral modulation attenuates molecular, endocrine, and neurobehavioral disruption induced by nocturnal light exposure

Rahman

Marcu²,

Shapiro

et al. 2011

American Journal of Physiology-Endocrinology and Metabolism

Self Cite

View full text Add to dashboard Cite

Rahman SA, Marcu S, Shapiro CM, Brown TJ, Casper RF. Spectral modulation attenuates molecular, endocrine, and neurobehavioral disruption induced by nocturnal light exposure. Am J Physiol Endocrinol Metab 300: E518 -E527, 2011. First published December 21, 2010; doi:10.1152/ajpendo.00597.2010.-The human eye serves distinctly dual roles in image forming (IF) and non-image-forming (NIF) responses when exposed to light. Whereas IF responses mediate vision, the NIF responses affect various molecular, neuroendocrine, and neurobehavioral variables. NIF responses can have acute and circadian phase-shifting effects on physiological variables. Both the acute and phase-shifting effects induced by photic stimuli demonstrate short-wavelength sensitivity peaking Ϸ450 -480 nm. In the current study, we examined the molecular, neuroendocrine, and neurobehavioral effects of completely filtering (0% transmission) all short wavelengths Ͻ480 nm and all short wavelengths Ͻ460 nm or partially filtering (ϳ30% transmission) Ͻ480 nm from polychromatic white light exposure between 2000 and 0800 in healthy individuals. Filtering short wavelengths Ͻ480 nm prevented nocturnal light-induced suppression of melatonin secretion, increased cortisol secretion, and disrupted peripheral clock gene expression. Furthermore, subjective alertness, mood, and errors on an objective vigilance task were significantly less impaired at 0800 by filtering wavelengths Ͻ480 nm compared with unfiltered nocturnal light exposure. These changes were not associated with significantly increased sleepiness or fatigue compared with unfiltered light exposure. The changes in molecular, endocrine, and neurobehavioral processes were not significantly improved by completely filtering Ͻ460 nm or partially filtering Ͻ480 nm compared with unfiltered nocturnal light exposure. Repeated light-dark cycle alterations as in rotating nightshifts can disrupt circadian rhythms and induce health disorders. The current data suggest that spectral modulation may provide an effective method of regulating the effects of light on physiological processes. circadian rhythms; short-wavelength light; melatonin; cortisol; alertness; mood; sleepiness.VARIOUS PHYSIOLOGICAL PROCESSES follow circadian (near-24-h) rhythms regulated by an endogenous pacemaker located in the suprachiasmatic nuclei (SCN) of the anterior hypothalamus. The SCN integrate endogenous and exogenous cues and synchronize the timing of physiological processes to environmental cycles (10). In most species, light is the strongest environmental time cue that resets circadian rhythms. Repeated changes in light-dark cycles, as in the case of shift work, can disrupt the synchronization between individual physiological processes and the synchronization between endogenous and external environmental rhythms, consequently inducing a wide range of health disorders (24, 54).In addition to phase-resetting effects, light exposure can also induce acute effects such as altered sympathetic regulation (50), rapid suppression of melatonin secretion (6...

show abstract

Prevention of melatonin suppression by nocturnal lighting: relevance to cancer

Cited by 26 publications

References 34 publications

Shift work and breast cancer among women textile workers in Shanghai, China

Shift work and breast cancer among women textile workers in Shanghai, China

Effects of television luminance and wavelength at habitual bedtime on melatonin and cortisol secretion in humans

Spectral modulation attenuates molecular, endocrine, and neurobehavioral disruption induced by nocturnal light exposure

Contact Info

Product

Resources

About