Prevention of Mutation, Cancer, and Other Age‐Associated Diseases by Optimizing Micronutrient Intake

Ames, Bruce N.

doi:10.4061/2010/725071

Cited by 43 publications

(30 citation statements)

References 157 publications

(180 reference statements)

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“…The diet containing this combination is here referred to as the Beaver Dam diet. We tested the combination of α-lipoic acid, acetyl-L-carnitine and biotin reported to optimize metabolism; delay mitochondrial decay; and decrease DNA damage, cancer, and other degenerative diseases of aging in rats (Ames 2004;Ames 2010). This combination is sold under the trade name Juvenon, and we here refer to the diet containing this supplement as the Juvenon diet.…”

Section: Combinations Testedmentioning

confidence: 99%

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice

Spindler

Mote

Flegal

2013

AGE

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Present data suggest that the consumption of individual dietary supplements does not enhance the health or longevity of healthy rodents or humans. It might be argued that more complex combinations of such agents might extend lifespan or health-span by more closely mimicking the complexity of micronutrients in fruits and vegetables, which appear to extend health-span and longevity. To test this hypothesis we treated long-lived, male, F1 mice with published and commercial combinations of dietary supplements and natural product extracts, and determined their effects on lifespan and health-span. Nutraceutical, vitamin or mineral combinations reported to extend the lifespan or health-span of healthy or enfeebled rodents were tested, as were combinations of botanicals and nutraceuticals implicated in enhanced longevity by a longitudinal study of human aging. A cross-section of commercial nutraceutical combinations sold as potential health enhancers also were tested, including Bone Restore®, Juvenon®, Life Extension Mix®, Ortho Core®, Ortho Mind®, Super K w k2®, and Ultra K2®. A more complex mixture of vitamins, minerals, botanical extracts and other nutraceuticals was compounded and tested. No significant increase in murine lifespan was found for any supplement mixture. Our diverse supplement mixture significantly decreased lifespan. Thus, our results do not support the hypothesis that simple or complex combinations of nutraceuticals, including antioxidants, are effective in delaying the onset or progress of the major causes of death in mice. The results are consistent with epidemiological studies suggesting that dietary supplements are not beneficial and even may be harmful for otherwise healthy individuals.

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Section: Combinations Testedmentioning

confidence: 99%

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice

Spindler

Mote

Flegal

2013

AGE

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“…Several methods were proposed to prevent mitochondrial dysfunction and improve mitochondrial metabolism. These methods rely on the development of pharmaceutical [17] or nutriceutical agents [18]. …”

Section: Mitochondrial Medicinementioning

confidence: 99%

Mitochondrial pharmacology: Electron transport chain bypass as strategies to treat mitochondrial dysfunction

2012

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Mitochondrial dysfunction (primary or secondary) is detrimental to intermediary metabolism. Therapeutic strategies to treat/prevent mitochondrial dysfunction could be valuable for managing metabolic and age-related disorders. Here, we review strategies proposed to treat mitochondrial impairment. We then concentrate on redox-active agents, with mild-redox potential, who shuttle electrons among specific cytosolic or mitochondrial redox-centers. We propose that specific redox agents with mild redox potential (−0.1 V; 0.1 V) improve mitochondrial function because they can readily donate or accept electrons in biological systems, thus they enhance metabolic activity and prevent reactive oxygen species (ROS) production. These agents are likely to lack toxic effects because they lack the risk of inhibiting electron transfer in redox centers. This is different from redox agents with strong negative (−0.4 V; −0.2 V) or positive (0.2 V; 0.4 V) redox potentials who alter the redox status of redox-centers (i.e., become permanently reduced or oxidized). This view has been demonstrated by testing the effect of several redox active agents on cellular senescence. Methylene blue (MB, redox potential ≅10 mV) appears to readily cycle between the oxidized and reduced forms using specific mitochondrial and cytosolic redox centers. MB is most effective in delaying cell senescence and enhancing mitochondrial function in vivo and in vitro. Mild-redox agents can alter the biochemical activity of specific mitochondrial components, which then in response alters the expression of nuclear and mitochondrial genes. We present the concept of mitochondrial electron-carrier bypass as a potential result of mild-redox agents, a method to prevent ROS production, improve mitochondrial function, and delay cellular aging. Thus, mild-redox agents may prevent/delay mitochondria-driven disorders.

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“…It has been estimated that the most of human cancer cases are due to environmental factors and would be preventable if the main risks could be identified (9,10). The role of diet is important and a number of studies have suggested that absence of certain dietary compounds, notably antioxidants, contribute to increasing the risk of malignancy (11)(12)(13)(14). There has been much interest in vitamin E, a biologically active phenol.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Vitamin E Novel Analogues as Anti-Cancer Compounds

Hosseini

Jalili

2016

Jundishapur J Nat Pharm Prod

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Background: Antioxidant compounds have been shown to slow down the development of chemically induced tumors. It has been estimated that most of human cancer cases are due to environmental factors and would be preventable if the main risks could be identified. The potential of vitamin E as a cancer preventive agent has been studied and individuals whose intake of vitamin E was above average showed a low risk of lung cancer. Vitamin E is a mixture of four lipid soluble phenols including α-, β-, γ-, and δ-tocopherol. Objectives: In our study, to investigate the antioxidant activity of α-tocopherol-derived radicals in comparison with other phenoxyl radicals, a number of substituted phenols were synthesized, most of which contained t-butyl groups in the 2-and 6-positions. Materials and Methods: All the synthesized compounds were recrystallized and the nuclear magnetic resonance (NMR) spectra were run on Bruker GRYOSPES WM 360 machine; the IR spectra were also run on a Perkin Elmer 1430 ratio recording infrared spectrophotometer. Microanalyses were carried out on a Perkin Elmer 4000 CHN analyzer; all the melting points were measured by an electrothermal melting point apparatus, which were uncorrected. Results: Five synthesized vitamin E analogues, including

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Prevention of Mutation, Cancer, and Other Age‐Associated Diseases by Optimizing Micronutrient Intake

Cited by 43 publications

References 157 publications

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice

Lifespan effects of simple and complex nutraceutical combinations fed isocalorically to mice

Mitochondrial pharmacology: Electron transport chain bypass as strategies to treat mitochondrial dysfunction

Synthesis of Vitamin E Novel Analogues as Anti-Cancer Compounds

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