Prevention of NAFLD-associated HCC: Role of lifestyle and chemoprevention

Lange, Naomi; Radu, Pompilia; Dufour, Jean‐François

doi:10.1016/j.jhep.2021.07.025

Cited by 92 publications

(59 citation statements)

References 114 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…33 Smoking, a carcinogenic factor in liver cancer, also has a negative impact on the development of NAFLD; however, our findings show that current nonsmokers have a much higher risk than current smokers. 34 We speculate that this result was found because these individuals were passive smokers or had quit smoking, and some studies show that quitting smoking may lead to NAFLD by increasing BMI. 35 In addition, passive smoking caused by sidestream smoke is more harmful than active smoking.…”

Section: Discussionmentioning

confidence: 81%

A Cross-Sectional Study of the Correlation Between the Atherogenic Index of Plasma and Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes

Lin¹,

Li²,

Wan³

2022

DMSO

View full text Add to dashboard Cite

Purpose The main objective of this study was to examine the possible association between the atherogenic index of plasma (AIP) and the prevalence of nonalcoholic fatty liver disease (NAFLD) in Chinese individuals with type 2 diabetes mellitus (T2DM). Patients and methods In this survey, data from 1074 patients with T2DM were retrospectively extracted. The correlations between each variable and NAFLD were determined by univariate analysis, and then, the statistically significant variables were evaluated for their association with AIP and NAFLD by multivariate regression analysis. Results AIP levels were significantly higher in all males and females with NAFLD than those without NAFLD (p<0.001). The prevalence of NAFLD increased progressively throughout the AIP quartiles (trend P < 0.001) and accounted for possible variables in Model 3 of the multivariate logistic regression analysis (OR: 2244.984). In terms of sensitivity and specificity, the AIP index was found to be 65.0% and 90.1% accurate, respectively, with a 95% CI of 0.804–0.893. According to a stratified analysis, females, patients over the age of 56 and current nonsmokers were found to have a higher chance of developing NAFLD. Conclusion T2DM individuals with NAFLD were found to have a higher AIP index than those without NAFLD. The prevalence and progression of NAFLD in T2DM patients may be influenced by the AIP index.

show abstract

Section: Discussionmentioning

confidence: 81%

A Cross-Sectional Study of the Correlation Between the Atherogenic Index of Plasma and Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes

Lin¹,

Li²,

Wan³

2022

DMSO

View full text Add to dashboard Cite

show abstract

“… 160 The beneficial effect of the Mediterranean diet and exercise seems to extend beyond the potential impact of weight loss and should be recommended to all patients with NAFLD/NASH. 161 …”

Section: Presentation Of Nafld-related Hccmentioning

confidence: 99%

Hepatocellular Carcinoma Due to Nonalcoholic Fatty Liver Disease: Current Concepts and Future Challenges

Ahmad¹,

Khan²,

Kodali³

et al. 2022

JHC

View full text Add to dashboard Cite

Obesity has been labeled as the global pandemic of the 21st century, resulting from a sedentary lifestyle and caloric excess. Nonalcoholic fatty liver disease (NAFLD), characterized by excessive hepatic steatosis, is strongly associated with obesity and metabolic syndrome and is estimated to be present in one-quarter of the world population, making it the most common cause of the chronic liver disease (CLD). NAFLD spectrum varies from simple steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. The burden of NAFLD has been predicted to increase in the coming decades resulting in increased rates of decompensated cirrhosis, hepatocellular carcinoma (HCC), and liver-related deaths. In the current review, we describe the pathophysiology of NAFLD and NASH, risk factors associated with disease progression, related complications, and mortality. Later, we have discussed the changing epidemiology of HCC, with NAFLD emerging as the most common cause of CLD and HCC. We have also addressed the risk factors of HCC development in the NAFLD population (including demographic, metabolic, genetic, dietary, and lifestyle factors), presentation of NAFLD-associated HCC, its prognosis, and the issue of HCC development in non-cirrhotic NAFLD. Lastly, the problems related to HCC screening in the NAFLD population, the remaining challenges, and future directions, especially the need to identify the high-risk individuals, will be discussed. We will conclude the review by summarizing the clinical evidence for treating fibrosis and preventing HCC in those at risk with NAFLD-associated HCC.

show abstract

“…Another issue is the definition, length, amount, and intensity of PA, ranging from vigorous aerobic exercise to resistance training or daily activity, which is not sedentary. The topic of PA and HCC was covered in an excellent review by Saran et al [ 50 ], and recently, the role of PA in the prevention of NAFLD-associated HCC was eluded to in a review by Lange et al [ 51 ]. In the following paragraph, we will focus specifically and extensively on the effect of PA on HCC.…”

Section: Role Of Physical Activity In Hccmentioning

confidence: 99%

Lifestyle and Hepatocellular Carcinoma What Is the Evidence and Prevention Recommendations

Zelber‐Sagi

Noureddin

Shibolet

2021

Cancers

View full text Add to dashboard Cite

The increasing burden of hepatocellular carcinoma (HCC) emphasizes the unmet need for primary prevention. Lifestyle measures appear to be important modifiable risk factors for HCC regardless of its etiology. Lifestyle patterns, as a whole and each component separately, are related to HCC risk. Dietary composition is important beyond obesity. Consumption of n-3 polyunsaturated fatty acids, as well as fish and poultry, are inversely associated with HCC, while red meat, saturated fat, and cholesterol are related to increased risk. Sugar consumption is associated with HCC risk, while fiber and vegetable intake is protective. Data from multiple studies clearly show a beneficial effect for physical activity in reducing the risk of HCC. However, the duration, mode and intensity of physical activity needed are yet to be determined. There is evidence that smoking can lead to liver fibrosis and liver cancer and has a synergistic effect with alcohol drinking. On the other hand, an excessive amount of alcohol by itself has been associated with increased risk of HCC directly (carcinogenic effect) or indirectly (liver fibrosis and cirrhosis progression. Large-scale intervention studies testing the effect of comprehensive lifestyle interventions on HCC prevention among diverse cohorts of liver disease patients are greatly warranted.

show abstract

Prevention of NAFLD-associated HCC: Role of lifestyle and chemoprevention

Cited by 92 publications

References 114 publications

A Cross-Sectional Study of the Correlation Between the Atherogenic Index of Plasma and Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes

A Cross-Sectional Study of the Correlation Between the Atherogenic Index of Plasma and Nonalcoholic Fatty Liver Disease in Patients with Type 2 Diabetes

Hepatocellular Carcinoma Due to Nonalcoholic Fatty Liver Disease: Current Concepts and Future Challenges

Lifestyle and Hepatocellular Carcinoma What Is the Evidence and Prevention Recommendations

Contact Info

Product

Resources

About