Prevention of necrosis in ischemic skin flaps using hydrogel of Rhizophora mangle

Silva, Luzia Abilio da; Lira, Eduardo Carvalho; Leal, Leila Bastos; Santana, Eduarda Santos de; Barbosa, Irla Carla de França; Silva, Yuri José de Albuquerque; Alves, Severino; Vieira, Jeymesson Raphael Cardoso

doi:10.1016/j.injury.2022.03.034

Cited by 5 publications

(6 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Other studies suggest that the extract of this plant has healing effects (Silva et al 2022, Sudhir et al 2022. Tannins appear to be responsible for the re-epithelialization (2024) 96(1) e20231143 8 | 11 mechanisms of the wound due to the increase in cell proliferation (Wu et al 2023) and their astringent and antimicrobial effects (Cano et al 2021).…”

Section: Healing Trialsmentioning

confidence: 99%

“…Rhizophora mangle showed inhibitory activities against both Gram-positive and Gram-negative strains due to its polyphenol composition (Rodríguez-García et al 2019), thus, tissue regeneration occur without the interference of those microorganisms. In addition, Rhizophora mangle also has antioxidant properties, which removes protease excesses and reactive oxygen species from wounds (Silva et al 2022).…”

Section: Healing Trialsmentioning

confidence: 99%

“…As an example of such a traditional therapy, we have the Rhizophora mangle, a mangrove plant that presents several uses in Brazilian popular medicine, mainly as an adjuvant in the healing of cutaneous wounds (Silva et al 2022).…”

Section: Introductionmentioning

confidence: 99%

“…The mangrove is a type of vegetation that grows in tropical and subtropical coastal regions, and presents polyphenolic compounds like tannins, which appears to be responsible for the mechanisms of skin re-epithelialization (Mitra et al 2021, Silva et al 2022. The effects attributed to R. mangle including antioxidant activity and antibacterial potential (Mitra et al 2021), increased cell proliferation and the formation of new blood vessels on the wound (Silva et al 2022) may be responsible for the improvement in the wound-healing response.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

A preliminary study of cutaneous wound healing on the upper eyelid in a small Brazilian population using Rhizophora mangle-based cream

SILVA,

LEAL,

SÁ

et al. 2024

An. Acad. Bras. Ciênc.

Self Cite

View full text Add to dashboard Cite

Plants used in traditional medicine offer an affordable new alternative in tissue repair therapy. This study aimed to evaluate the effectiveness of the 5% Rhizophora mangle cream compared to the 5% dexpanthenol cream in healing open surgical wounds on the upper eyelid. A total of 18 patients were submitted to the experiment and divided into 2 groups with 9 patients each who used topically and daily 5% dexpanthenol cream (control group) or 5% R.mangle cream (intervention group) for 7 days. Clinical, morphometric and histomorphometric analyses of wounds and surgical procedures for skin removal were performed. In the morphometric analysis, all wounds treated with R.mangle and dexpanthenol creams showed complete macroscopic scars, without inflammatory signs and infection free. The skin hydration values in pre and post application periods of the cream were 43.82 ± 43.93 and 62.12 ± 67.40 respectively.The histomorphometric study showed lower values of epithelium distance in R. mangle group and higher in dexpanthenol group with significant difference between groups (p < 0.05). The R.mangle 5% cream proved to be effective in healing wounds of human upper eyelid skin with a significant improvement in epithelization compared to dexpanthenol 5% cream.

show abstract

Section: Healing Trialsmentioning

confidence: 99%

Section: Healing Trialsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

A preliminary study of cutaneous wound healing on the upper eyelid in a small Brazilian population using Rhizophora mangle-based cream

SILVA,

LEAL,

SÁ

et al. 2024

An. Acad. Bras. Ciênc.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The plant's pharmacological properties depend on the secondary compounds produced, which, in addition to ensuring its survival, have several biological activities. [7] Mangroves are extensively studied for their antimicrobial properties. [16] Compounds such as kaempferol-3-O-rutinoside have antibacterial and antifungal efficacy against strains of Candida albicans, Staphylococcus aureus, and Pseudomonas aeruginosa.…”

Section: Introductionmentioning

confidence: 99%

Dereplication Tools for Rhizophora mangle Extracts from Different Mangrove Areas and their Potential Against Staphylococcus aureus

da Silva Pontes,

Monteiro Leal,

Pereira Lucas

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Rhizophora extracts have several potential biological activities, and their metabolites can be used in the pharmaceutical industry. Extracts of Rhizophora species obtained from mangroves have shown prospective activity against Staphylococcus aureus. This study aimed to investigate the chemical profile of Rhizophora mangle leaves from fringe, basin, and transition mangrove zones and their bactericidal/bacteriostatic potential against S. aureus. R. mangle leaves were collected monthly in 2018 from litterfall in three different zones of the mangrove of Guaratiba State Reserve: fringe, basin, and transition. Extracts were prepared from the material collected in October and December for LC‐HRMS/MS analysis, and dereplication was performed using a molecular library search and the classical molecular networking GNPS platform. The minimum inhibitory concentrations (MICs) of the aqueous extract of R. mangle against S. aureus were determined. No S. aureus growth was observed compared to the control for extracts collected from September to December. Different compounds were annotated in each region, yet a marked presence of phenolic compounds was noted, among them glycosylated flavonoid derivatives of quercetin and kaempferol. The results suggest bactericidal/bacteriostatic activity for extracts of R. mangle leaves collected in 2018 from three mangrove forest zones.

show abstract

Evidence for the efficacy of anti-inflammatory plants used in Brazilian traditional medicine with ethnopharmacological relevance

de Matos,

Bitencourt,

de Oliveira

et al. 2024

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Prevention of necrosis in ischemic skin flaps using hydrogel of Rhizophora mangle

Cited by 5 publications

References 21 publications

A preliminary study of cutaneous wound healing on the upper eyelid in a small Brazilian population using Rhizophora mangle-based cream

A preliminary study of cutaneous wound healing on the upper eyelid in a small Brazilian population using Rhizophora mangle-based cream

Dereplication Tools for Rhizophora mangle Extracts from Different Mangrove Areas and their Potential Against Staphylococcus aureus

Evidence for the efficacy of anti-inflammatory plants used in Brazilian traditional medicine with ethnopharmacological relevance

Contact Info

Product

Resources

About