Prevention of nephrotoxicity induced by amikacin: The role of misoprostol, A prostaglandin E1 analogue

Azırak, Sebile

doi:10.1016/j.prostaglandins.2022.106682

Cited by 3 publications

(2 citation statements)

References 61 publications

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“…6 However, misoprostol, a prostaglandin E1 analogue, acts as a renal vasodilator and exerts antioxidant and anti-inflammatory effects. 8,40 Although the mechanism underlying the preventive effect of misoprostol on NSAID-induced kidney injury remains unclear, it is reported that misoprostol might prevent NSAIDinduced elevation in blood pressure, renal vasoconstriction and interstitial inflammation via the action of prostaglandin E1. 38,41 We also found a possible increase in severe adverse events in patients who received misoprostol.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, the risk of acute interstitial nephritis increases with increasing production of proinflammatory leukotrienes 6 . However, misoprostol, a prostaglandin E1 analogue, acts as a renal vasodilator and exerts antioxidant and anti‐inflammatory effects 8,40 . Although the mechanism underlying the preventive effect of misoprostol on NSAID‐induced kidney injury remains unclear, it is reported that misoprostol might prevent NSAID‐induced elevation in blood pressure, renal vasoconstriction and interstitial inflammation via the action of prostaglandin E1 38,41 …”

Section: Discussionmentioning

confidence: 99%

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Association between misoprostol and nonsteroidal anti‐inflammatory drug‐induced kidney injury: A systematic review and meta‐analysis

Mitsuboshi

Kotake

Takahashi

et al. 2023

Brit J Clinical Pharma

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AimsMisoprostol is a prostaglandin E1 analogue that is used to prevent nonsteroidal anti‐inflammatory drug (NSAID)‐induced gastrointestinal disorders. The aim of this systematic review and meta‐analysis was to evaluate whether use of misoprostol also decreases the risk of NSAID‐induced kidney injury.MethodsRandomized controlled trials that compared misoprostol vs. placebo in an adult patient population were selected. The primary outcome was kidney injury and the secondary outcome was severe adverse events. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation approach.ResultsTwelve studies were eligible for inclusion. Although the rates of kidney injury and severe adverse events did not differ significantly between misoprostol and placebo, a posthoc subgroup analysis that excluded studies in which different NSAIDs were used in the misoprostol and placebo groups suggested that misoprostol may reduce the risk of NSAID‐induced kidney injury (risk difference −0.09, 95% confidence interval −0.15 to −0.03, P < .01, I2 = 87%; evidence of very low certainty).ConclusionThere is limited evidence that misoprostol reduces the risk of NSAID‐induced kidney injury. Misoprostol possibly contributes to reducing the risk of kidney injury associated with chronic NSAID use. The findings of this meta‐analysis suggest further high‐quality clinical trials are warranted.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Association between misoprostol and nonsteroidal anti‐inflammatory drug‐induced kidney injury: A systematic review and meta‐analysis

Mitsuboshi

Kotake

Takahashi

et al. 2023

Brit J Clinical Pharma

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The renoprotective activity of amikacin–gamma-amino butyric acid–chitosan nanoparticles: a comparative study

Madbouly,

Ooda,

Nabil

et al. 2024

Inflammopharmacol

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The development of nanoparticles (NPs) with active components with upgraded stability, and prolonged release helps in enhanced tissue regeneration. In addition, NPs are feasible strategy to boost antibiotic effectiveness and reduce drug side effects. Our study focuses on the use of amikacin (AMK) and gamma amino butyric acid (GABA) unloaded combinations or loaded on chitosan nanoparticles (CSNPs) for kidney protection. The AMK–GABA–CSNPs were prepared with the ionic gelation method, the morphology was studied using transmission electron microscopy (TEM), zetasizer and the Fourier transform-infrared spectroscopy (FT-IR) spectrum of the synthesized NPs was observed. The average size of AMK–GABA–CSNPs was 77.5 ± 16.5 nm. Zeta potential was + 38.94 ± 2.65 mV. AMK–GABA–CSNPs revealed significant in vitro antioxidant, anti-coagulation, non-hemolytic properties and good cell compatibility. To compare the effects of the unloaded AMK–GABA combination and AMK–GABA–CSNPs on the renal tissue, 42 healthy Sprague–Dawley rats were divided into seven groups. G1: normal control (NC), normal saline; G2: low-dose nephrotoxic group (LDN), AMK (20 mg/kg/day; i.p.); G3: unloaded AMK (20 mg/kg/day; i.p.) and GABA (50 mg/kg/day; i.p.); G4: AMK–GABA–CSNPs (20 mg/kg/day; i.p.); G5: high-dose nephrotoxic group (HDN), AMK (30 mg/kg/day; i.p.); G6: unloaded AMK (30 mg/kg/day; i.p.) and GABA (50 mg/kg/day; i.p.) and G7: AMK–GABA–CSNPs (30 mg/kg/day; i.p.). The results showed that AMK–GABA–CSNPs formulation is superior to unloaded AMK–GABA combination as it ameliorated kidney functions, oxidative stress and displayed a significant homeostatic role via suppression of inflammatory cytokines of Th1, Th2 and Th17 types. Hence, AMK–GABA–CSNPs could afford a potential nano-based therapeutic formula for the management of AMK-nephrotoxicity.

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Metal-Responsive Fluorophore and Amikacin-Conjugated Heparin for Bacterial Cell Imaging and Antibacterial Applications

Karn,

Biswas,

Srimayee

et al. 2024

ACS Infect. Dis.

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Prevention of nephrotoxicity induced by amikacin: The role of misoprostol, A prostaglandin E1 analogue

Cited by 3 publications

References 61 publications

Association between misoprostol and nonsteroidal anti‐inflammatory drug‐induced kidney injury: A systematic review and meta‐analysis

Association between misoprostol and nonsteroidal anti‐inflammatory drug‐induced kidney injury: A systematic review and meta‐analysis

The renoprotective activity of amikacin–gamma-amino butyric acid–chitosan nanoparticles: a comparative study

Metal-Responsive Fluorophore and Amikacin-Conjugated Heparin for Bacterial Cell Imaging and Antibacterial Applications

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