2020
DOI: 10.1007/s00520-019-05258-2
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Prevention of oral mucositis with cryotherapy in children undergoing hematopoietic stem cell transplantations—a feasibility study and randomized controlled trial

Abstract: Purpose To evaluate the feasibility of oral cryotherapy (OC) in children and to investigate if OC reduces the incidence of severe oral mucositis (OM), oral pain, and opioid use in children undergoing hematopoietic stem cell transplantation (HSCT) . Methods Fifty-three children, 4–17 years old, scheduled for HSCT in Sweden were included and randomized to OC or control using a computer-generated list. OC instructions were to cool the mouth with ice for as … Show more

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Cited by 24 publications
(71 citation statements)
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“…It is defined as an inflammation of oropharynx resulting from cancer therapy typically manifesting as atrophy, swelling, erythema and ulceration 1 . It affects 80% of children undergoing HSCT, 3 and usually occurs between two and 18 days following the initiation of the chemotherapy 2 . It is generally accepted that the pathophysiology of OM is a complex multistage phenomenon that can result from damage to the oral mucosal cells by free radicals produced by the drugs used in chemotherapy 4 .…”
Section: Introductionmentioning
confidence: 99%
“…It is defined as an inflammation of oropharynx resulting from cancer therapy typically manifesting as atrophy, swelling, erythema and ulceration 1 . It affects 80% of children undergoing HSCT, 3 and usually occurs between two and 18 days following the initiation of the chemotherapy 2 . It is generally accepted that the pathophysiology of OM is a complex multistage phenomenon that can result from damage to the oral mucosal cells by free radicals produced by the drugs used in chemotherapy 4 .…”
Section: Introductionmentioning
confidence: 99%
“…As previously reported in adult patients, 19 60 min of cryotherapy was sufficient for pediatric patients receiving a 30‐min intravenous infusion of MEL; however, this procedure is still uncomfortable, particularly for infants and young children 23 . MEL may be safely administered by a bolus intravenous injection that may increase compliance to the procedure and thus, decrease the incidence of OM by shortening the duration of cryotherapy.…”
Section: Discussionmentioning
confidence: 67%
“…Measurement of mucositis: mucositis was evaluated for both experimental and control groups, according to the World Health Organization (WHO) mucositis assessment scale (9) , a scale considered ideal because it incorporates both clinical and functional factors, and has its validity established in several studies on the theme (8,(11)(12)(13) . On this scale, mucositis is classified into four grades, namely: Grade 0: no changes; Grade 1: erythema; with or without pain; Grade 2: erythema, ulcers, the patient can eat a solid diet; Grade 3: ulcers, extensive erythema, the patient is unable to eat a solid diet; Grade 4: extensive mucositis that does not allow oral feeding.…”
Section: Methodsmentioning
confidence: 99%