Prevention of Oxidative Stress-Induced Apoptosis of C2C12 Myoblasts by a &lt;i&gt;Cichorium intybus&lt;/i&gt; Root Extract

Lee, Yong-Hyeon; Kim, Dae-Hyun; Kim, Yoon Suk; Kim, Tack-Joong

doi:10.1271/bbb.120465

Cited by 21 publications

(10 citation statements)

References 29 publications

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“…The adaptogens extracted from roots of Eleutherococcus senticosus , Schisandra chinensis berry, and Rhodiola rosea are also reported to increase HSP70 when tested in isolated human neuroglia cells [ 103 ]. Similarly, ethanolic leave extracts from Cichorium intybus and Jasminum sambac also induced HSP70 expression in C2C12 myoblasts and rats tissue [ 104 , 105 ]. All these research reports strongly suggest that natural bioactive phytochemicals have pivotal roles in increasing HSPs expression, which may prevent neurodegenerative diseases.…”

Section: Natural Antidotes To Boost the Hsp Systemmentioning

confidence: 99%

Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin

Maiti

Manna

Veleri

et al. 2014

BioMed Research International

106

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The intra- and extracellular accumulation of misfolded and aggregated amyloid proteins is a common feature in several neurodegenerative diseases, which is thought to play a major role in disease severity and progression. The principal machineries maintaining proteostasis are the ubiquitin proteasomal and lysosomal autophagy systems, where heat shock proteins play a crucial role. Many protein aggregates are degraded by the lysosomes, depending on aggregate size, peptide sequence, and degree of misfolding, while others are selectively tagged for removal by heat shock proteins and degraded by either the proteasome or phagosomes. These systems are compromised in different neurodegenerative diseases. Therefore, developing novel targets and classes of therapeutic drugs, which can reduce aggregates and maintain proteostasis in the brains of neurodegenerative models, is vital. Natural products that can modulate heat shock proteins/proteosomal pathway are considered promising for treating neurodegenerative diseases. Here we discuss the current knowledge on the role of HSPs in protein misfolding diseases and knowledge gained from animal models of Alzheimer's disease, tauopathies, and Huntington's diseases. Further, we discuss the emerging treatment regimens for these diseases using natural products, like curcumin, which can augment expression or function of heat shock proteins in the cell.

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Section: Natural Antidotes To Boost the Hsp Systemmentioning

confidence: 99%

Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin

Maiti

Manna

Veleri

et al. 2014

BioMed Research International

106

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“…intybus extract also inhibited the level of intracellular ceramide. These results indicate that Cichorium intybus extract may prevent skeletal muscle atrophy by inducing the expression of Hsp 70 and inhibiting the level of ceramide [57].…”

Section: Introductionmentioning

confidence: 68%

Medicinal plants with antioxidant and free radical scavenging effects (part 2): plant based review

Al-Snafi¹

2016

IOSRPHR

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Previous studies showed that a wide range of medicinal plants exerted antioxidant and free radical scavenging activity. These plants included: Cicer arietinumThe free radicals scavenging, antioxidant properties and intestinal α-glucosidase inhibitory activity of methanol extract of two varieties of Cicer arietinum were evaluated. Compared with raw seeds increase in total polyphenol and flavonoids concentration in green gram sprouts and Kabuli Chana sprouts (KCs) were recorded. Total protein concentrations in sprouts did not differ from non-sprouted grains. 2,2'-Azinobis (3-ethyl benzthiazoline-6-sulphonic acid) cation scavenging activity was more than twice in Bengal gram sprouts of (BGs) and KCs than their raw seeds. 2,2-diphenyl-1-picrylhydrazyl, hydrogen peroxide scavenging, nitro blue tetrazolium reducing and glucose-induced Hb-glycation inhibitory activity did not differ from non-sprouted raw grains. Increase in rat intestinal α-glucosidase inhibitory activity was observed in BGs and KCs. BGs significantly mitigated first 30 min starch-induced postprandial glycemic excursions and reduced 2 h postprandial glycemic load [44][45].The extent of free radical scavenging properties and antioxidant effects of crude extracts of sprouted Cicer arietinum (Chick pea/Chana/Bengal gram) seeds were evaluated. Two main varieties of Cicer arietinum seeds viz. Kabuli-Chana (cream seed-coat) and Bengal gram (brown seed-coat) were examined and compared for their free radical scavenging properties and antioxidant effects. Free radical scavenging properties were evaluated against stable 2, 2-diphenyl-1-picrylhydrazyl radical (DPPH) and hydrogen peroxide radical and the Medicinal plants with antioxidant and free radical scavenging 63 extent of antioxidant effect was assessed by lipid peroxidation induced by ferrous sulphate on the lipid present in the liver homogenate. The results showed that the two Cicer arietinum extracts were differed in their capacities to quench or inhibit DPPH, hydrogen peroxide and lipid peroxide. Brown colored Cicer arietinum sprouts showed the greatest activity against DPPH radicals, hydrogen peroxide radicals and lipid peroxide compared to the cream variety [45][46].The root of Cicer arietinum was extracted using solvents of different polarities and explored for in vitro free radical scavenging activity. Preliminary assays of three different extracts of Cicer arietinum root showed that the extracts possess electron donating ability and reduction of ferric ion to ferrous in a cell free system at pH-7.4. It has also been found from total antioxidant capacity as assessed by reduction of molybdate showed Cicer arietinum root extracts to possess (standard) ascorbic acid equivalents per milligrams of the extracts. Hydroalcoholic root extract was found more effective when compared to alcoholic and water extracts in scavenging 1, 1-diphenyl-2-picrylhydrazyl, reducing ferric ion and molybdate reduction in antioxidant capacity. A significant correlations exist between extract concentrations and percentage scaveng...

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“…Also, Camellia sinensis extracts in rats appear to counteract the increased protein degradation (linked with its ability to downregulate key components of the ubiquitin proteasome proteolytic pathway) [ 25 ]. Instead, Cichorium intybus extract prevents skeletal muscle atrophy in vitro, probably increasing heat-shock protein-70 (Hsp-70) production and inhibiting the level of ceramide: Hsp-70, in fact, has a positive effect on reducing oxidative stress of cells and ceramide is involved in the regulation of cell death [ 45 ]. Also, chestnut sweet flour (rich in γ -tocopherol) protects from skeletal muscle cell atrophy, but this protection appears not to be due to a general antioxidant action, but maintaining cellular redox homeostasis through the regulation of NADPH oxidase, mitochondrial integrity [ 29 ].…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review on the Effects of Botanicals on Skeletal Muscle Health in Order to Prevent Sarcopenia

Rondanelli

Miccono

Peroni

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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We performed a systematic review to evaluate the evidence-based medicine regarding the main botanical extracts and their nutraceutical compounds correlated to skeletal muscle health in order to identify novel strategies that effectively attenuate skeletal muscle loss and enhance muscle function and to improve the quality of life of older subjects. This review contains all eligible studies from 2010 to 2015 and included 57 publications. We focused our attention on effects of botanical extracts on growth and health of muscle and divided these effects into five categories: anti-inflammation, muscle damage prevention, antifatigue, muscle atrophy prevention, and muscle regeneration and differentiation.

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Prevention of Oxidative Stress-Induced Apoptosis of C2C12 Myoblasts by a <i>Cichorium intybus</i> Root Extract

Cited by 21 publications

References 29 publications

Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin

Molecular Chaperone Dysfunction in Neurodegenerative Diseases and Effects of Curcumin

Medicinal plants with antioxidant and free radical scavenging effects (part 2): plant based review

A Systematic Review on the Effects of Botanicals on Skeletal Muscle Health in Order to Prevent Sarcopenia

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