1990
DOI: 10.1016/0140-6736(90)92533-n
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Prevention of Pneumocystis carinii pneumonitis in AIDS patients with weekly dapsone

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Cited by 48 publications
(18 citation statements)
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“…As expected on the basis of the half-lives of 23-25 hours for dapsone and 80-105 hours for pyrimethamine [28,29], serum concentrations of dapsone decreased considerably throughout the weekly dosing interval, whereas pyrimethamine levels remained relatively stable in most of the sera examined [20]. Maintenance of high serum levels may be less important for prophylaxis than for cure, as shown by the experience with weekly doses of dapsone [18] and that with intermittent doses of trimethoprim-sulfamethoxazole [6,24,30]: both regimens prevented PCP, although the dosing interval exceeded the half-life of the individual compounds severalfold. Investigators in one of the latter studies reported undetectable trough levels in the majority of patients despite prophylactic efficacy [30].…”
Section: Discussionmentioning
confidence: 75%
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“…As expected on the basis of the half-lives of 23-25 hours for dapsone and 80-105 hours for pyrimethamine [28,29], serum concentrations of dapsone decreased considerably throughout the weekly dosing interval, whereas pyrimethamine levels remained relatively stable in most of the sera examined [20]. Maintenance of high serum levels may be less important for prophylaxis than for cure, as shown by the experience with weekly doses of dapsone [18] and that with intermittent doses of trimethoprim-sulfamethoxazole [6,24,30]: both regimens prevented PCP, although the dosing interval exceeded the half-life of the individual compounds severalfold. Investigators in one of the latter studies reported undetectable trough levels in the majority of patients despite prophylactic efficacy [30].…”
Section: Discussionmentioning
confidence: 75%
“…Dapsone and pyrimethamine have been active against both organisms in vitro and in murine models [15][16][17]; therefore, this combination was chosen for evaluation as combined prophylaxis for PCP and toxoplasmic encephalitis. Low cost and the potential for once-weekly administration [18] are additional attractive features of the dapsone/ pyrimethamine combination. As aerosolized pentamidine…”
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confidence: 99%
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“…Dapsone is a synthetic antifolate that has activity against Mycobacterium leprae (15) and, when it is used alone or in combination with pyrimethamine, prevents Pneumocystis cannii pneumonia (6,21); dapsone has been reported to have in vitro activity against MAC (16). We now report on the use of clarithromycin alone or in combination with dapsone to treat and prevent disseminated MAC infection in beige mice.…”
mentioning
confidence: 99%
“…Alternative prophylactic regimens for the sulfa-allergic patient include aerosolized pentamidine (for patients Ͼ 5 years of age) 78 and dapsone. 79 Tuberculosis (TB) is of concern in recipients of LTx. Development of TB after pediatric LTx is extremely uncommon, with only 11 cases reported to date, [80][81][82] although the incidence of TB after LTx in adults in Europe and the United States has ranged from 0.9% to 2.3%.…”
Section: Opportunistic Infectionsmentioning
confidence: 99%