Prevention of Post-Traumatic Pulmonary Insufficiency

Reul, George J.

doi:10.1001/archsurg.1973.01350160008002

Cited by 114 publications

(12 citation statements)

References 30 publications

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“…Microaggregate blood filters are primarily designed to protect the pulmonary and cerebral circulations from emboli present in stored blood [9]. It is agreed that these filters remove aggregated debris more efficiently than the standard administration set filters, but their necessity and clinical benefit have not been proven conclusively [lo].…”

Section: Discussionmentioning

confidence: 99%

Preparation of Granulocyte‐Poor Red Blood Cells by Microaggregate Filtration

et al. 1980

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A simple, effective method for removing granulocytes from stored blood is described. Microaggregate filtration removes approximately 95% of the granulocytes from blood which has been stored for 2 weeks, centrifuged and filtered. The mean number of remaining leukocytes is 8 +/- 3.7 x 10(8)/unit. The residual white cell population, which is composed almost entirely of lymphocytes, is substantially less than the average number of cells previously associated with febrile reactions. 45 patients were selected for the study. All had significant febrile transfusion reaction histories, and averaged one reaction for every 3.6 U of conventional red cell product transfused. Administration of 212 units of microaggregate filtered granulocyte poor red cells caused a 95% reduction in the incidence of fibrile reactions. The technique is inexpensive, easily incorporated into the routine of the clinical blood bank, and does not require "open-system' processing. These considerations make microaggregate filtration a logical first choice method for the preparation of granulocyte-poor red blood cells.

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Section: Discussionmentioning

confidence: 99%

Preparation of Granulocyte‐Poor Red Blood Cells by Microaggregate Filtration

et al. 1980

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“…Microaggregate blood filters are primarily designed to protect the pulmonary and cere bral circulations from emboli present in stored blood [9]. It is agreed that these fil ters remove aggregated debris more efficient ly than the standard administration set fil ters, but their necessity and clinical benefit have not been proven conclusively [10].…”

Section: Discussionmentioning

confidence: 99%

Preparation of Granulocyte-Poor Red Blood Cells by Microaggregate Filtration

et al. 1980

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A simple, effective method for removing granulocytes from stored blood is described. Microaggregate filtration removes approximately 95% of the granulocytes from blood which has been stored for 2 weeks, centrifuged and filtered. The mean number of remaining leukocytes is 8 ± 3.7 x 10^8 / unit. The residual white cell population, which is composed almost entirely of lymphocytes, is substantially less than the average number of cells previously associated with febrile reactions. 45 patients were selected for the study. All had significant febrile transfusion reaction histories, and averaged one reaction for every 3.6 U of conventional red cell product transfused. Administration of 212 units of microaggregate filtered granulocyte poor red cells caused a 95% reduction in the incidence of fibrile reactions. The technique is inexpensive, easily incorporated into the routine of the clinical blood bank, and does not require ‘open-system’ processing. These considerations make microaggregate filtration a logical first choice method for the preparation of granulocyte- poor red blood cells.

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“…When each experiment was completed, the filter was gently washed with Ringer's lactate (about 500 ml) and the deposits were then fixed using a phosphate buffered 3% glutaraldehyde solution [7]. After 8 to 15 days of fixation the filters were dismantled in order to remove small samples for scanning electron microscope examination (SEM).…”

Section: Methodsmentioning

confidence: 99%

Stored blood microfiltration

et al. 1977

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Aggregates of amorphous material which develop during storage of banked blood have been implicated as a cause of pulmonary micro-embolism in man following massive transfusion. Such pulmonary micro-embolism may be a causal factor in the development of post traumatic pulmonary insufficiency. At present several microaggregate filters for use in massive transfusion are commercially available, and on of these is the Fenwal filter. It is composed of a screen filter which removes microclots of 250 microns and higher, a layer of polyurethane foam and a layer of nylon wool. The resistance of this device is very acceptable and the filter may be used for several blood units, but its efficiency seems less than that of Dacron wool filter.

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Prevention of Post-Traumatic Pulmonary Insufficiency

Cited by 114 publications

References 30 publications

Preparation of Granulocyte‐Poor Red Blood Cells by Microaggregate Filtration

Preparation of Granulocyte‐Poor Red Blood Cells by Microaggregate Filtration

Preparation of Granulocyte-Poor Red Blood Cells by Microaggregate Filtration

Stored blood microfiltration

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