Prevention of Postoperative Adhesions in Rabbits with Streptococcal Metabolites.

Wright, Louis T.; Smith, David H.; Rothman, Milton; Quash, Eugene T.; Metzger, William I.

doi:10.3181/00379727-75-18278

Cited by 24 publications

(5 citation statements)

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“…These findings agree with those reported by Wright et al ., who observed a smaller number of adhesions in rabbits when they used streptokinase and streptodornase. [ 34 ] Similar data were reported by Luttwak et al ., in a study of the prevention of adhesions in rats induced by the presence of talcum in the peritoneal cavity. [ 35 ]…”

Section: Discussionsupporting

confidence: 86%

Effects of Streptokinase and Normal Saline on the Incidence of Intra-abdominal Adhesion 1 Week and 1 Month after Laparotomy in Rats

et al. 2018

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Background:Intra-abdominal adhesions after surgery are usually in the form of bands and can annoy the patient throughout life causing repeated surgical procedures. Therefore, any action to prevent adhesions after surgery can increase longevity and quality of life. For this aim, this study investigates the effect of streptokinase and normal saline on the 7th day and 1 month after laparotomy.Materials and Methods:Experimental study was conducted on thirty healthy male Wistar rats weighing 200–250 g with age of 3 months divided into three groups of 10. Group I: No treatment, Group II: Received normal saline, and Group III: Received normal saline and streptokinase at the same time. One week and 1 month after laparotomy, the frequency of the presence or absence of adhesion bands was performed by a person who was unaware of the sample grouping. The collected information was analyzed with the SPSS software (version 16; SPSS Inc., Chicago, IL, USA).Results:Adhesion frequency was found to be 20% on the 7th day (early) and 1 month after laparotomy (late) for Group 1, and it was 40% on early and late for Group II, while 0% on the early and late for Group III. Hence, in the group receiving streptokinase, no early or late adhesion was observed; therefore, it had a significant role in the prevention of intra-abdominal adhesions (P < 0.05). However, adhesions in the group receiving normal saline had no remarkable difference with the group receiving no drug (P > 0.05).Conclusion:According to the results of our study, we believe that streptokinase could be a good antiadhesive agent considering its effectiveness.

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Section: Discussionsupporting

confidence: 86%

Effects of Streptokinase and Normal Saline on the Incidence of Intra-abdominal Adhesion 1 Week and 1 Month after Laparotomy in Rats

et al. 2018

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“…Intraperitoneal administration of pepsin, trypsin, papain, streptokinase, urokinase, hyaluronidase, fibrinolysin and protoporfirin has been used for the prevention of postoperative adhesions with limited success [3,15,16]. In this study, 50,000 IU/kg streptokinase administered intraperitoneally showed no significant effect for the prevention of postoperative adhesions.…”

Section: Discussionmentioning

confidence: 69%

Reduction of Surgery-Induced Peritoneal Adhesions by Continuous Release of Streptokinase from a Drug Delivery System

Yağmurlu¹,

Barlas²,

Gürsel³

et al. 2003

Eur Surg Res

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Postoperative abdominal adhesions may lead to intestinal obstruction and infertility. The effect of continuous release of streptokinase to the peritoneal cavity on postoperative adhesions was examined under experimental conditions. Peritoneal adhesions were induced in rats and the animals were further treated by intraperitoneal administration of streptokinase solution, polyhydroxybutyrate-co-hydroxyvalerate (PHBV) membrane alone and streptokinase loaded PHBV membrane and compared to sham operated and untreated groups. Formation of adhesions was evaluated by quantitative macroscopic grading, histopathologically with light microscopy, on the following week. Streptokinase loaded PHBV prevented postoperative adhesion formation in 90% of the cases. PHBV membrane alone also reduced the severity of adhesions due to its anti-adhesive properties. Histopathological examination revealed limited foreign body reaction due to PHBV. Continuous streptokinase activity in the peritoneal cavity during early post-surgical period prevents postoperative adhesion.

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“…In the late 19th century, agents with potential fibrinolytic capacity, including liquor thiosinamine with sodium salicylate31 and oral phosphorus32, were advocated. Streptokinase and streptodornase were the first agents with proven fibrinolytic properties that were effective in preventing adhesion formation in rabbits and rats33, 34. Although both agents had theoretical value, their efficacy was never proven in humans.…”

Section: Prevention Of Adhesionsmentioning

confidence: 99%

Pathophysiology of intra-abdominal adhesion and abscess formation, and the effect of hyaluronan

Reijnen

Bleichrodt

Goor

2003

British Journal of Surgery

124

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Prevention of Postoperative Adhesions in Rabbits with Streptococcal Metabolites.

Abstract: 18278) LOUIS T. \\-RIGHT, I)A\.ID H. SNTTH, ,\JILTON ROTHMAN, EUGENE T. QUASH, ASD \\*ILLIAM 1. METZGER F r o m thr D c p w t iiictzt o! S u r g e r y , Hn&i?i Hospital, S e w Y o r k Cit?

Cited by 24 publications

References 0 publications

Effects of Streptokinase and Normal Saline on the Incidence of Intra-abdominal Adhesion 1 Week and 1 Month after Laparotomy in Rats

Effects of Streptokinase and Normal Saline on the Incidence of Intra-abdominal Adhesion 1 Week and 1 Month after Laparotomy in Rats

Reduction of Surgery-Induced Peritoneal Adhesions by Continuous Release of Streptokinase from a Drug Delivery System

Pathophysiology of intra-abdominal adhesion and abscess formation, and the effect of hyaluronan

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