Prevention of Postoperative Thromboembolism by Dextran 40, Low Doses of Heparin, or Xantinol Nicotinate

Gruber, Ulrich F.; Fridrich, R; Duckert, F; Torhorst, J.; Rem, J. A.

doi:10.1016/s0140-6736(77)91011-x

Cited by 86 publications

(22 citation statements)

References 3 publications

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“…We intentionally started administration on the eve of operation since we are looking for prophylactic methods which are simple enough to be used in as many surgical patients as possi ble, including emergency surgery where thromboembolic complications are common. Dextran-70 did not reduce the incidence of deep-vein thrombosis in this study as much as in our previous trial with dextran-40 [6]. It is well known that dextran does not reduce the incidence of deep vein thrombosis as much as small doses of heparin when judged by the fi brinogen test [5,6,16].…”

Section: Discussioncontrasting

confidence: 42%

“…Dextran-70 did not reduce the incidence of deep-vein thrombosis in this study as much as in our previous trial with dextran-40 [6]. It is well known that dextran does not reduce the incidence of deep vein thrombosis as much as small doses of heparin when judged by the fi brinogen test [5,6,16]. In spite of this, dextran is apparently very effec tive in reducing the incidence of fatal pulmonary embolism [5,6,16].…”

Section: Discussioncontrasting

confidence: 41%

“…The reason for the trial was explained to each patient and their consent obtained before entry into the study. The patients included fulfilled the criteria used in the International Multi centre Trial of Prophylactic Subcutaneous Heparin for the Prevention of Postopera tive Venous Thrombosis [11], in which we were participating [6]. According to this protocol [11], a major operation was considered to be one which was performed un der general anaesthesia, lasted for more than half an hour and required a postoper ative hosptial stay of at least 7 days.…”

Section: Methodsmentioning

confidence: 99%

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Sulfinpyrazone and Postoperative Deep Vein Thrombosis

Gruber¹,

Buser²,

Frick³

et al. 1977

Eur Surg Res

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Small doses of subcutaneous heparin and infusions of dextran both reduce the incidence of fatal pulmonary embolism after elective general surgery. But both methods have disadvantages. Therefore, the protection against deep vein thrombosis afforded by sulfínpyrazone, a drug which can be taken by mouth as well as by injection, was assessed in a prospective study of 119 patients undergoing elective general or urological surgery. The prophylactic administration of sulfínpyrazone was compared with the effects of small doses of sodium heparin and infusions of dextran-70. The ¹²⁵I-fibrinogen test was carried out in all patients during their hospitalization. Deep vein thrombosis was diagnosed in 13 of 30 patients (43%) who received sulfínpyrazone, in 9 of 29 (31%) receiving dextran-70 and in 2 of 22 (9%) having subcutaneous heparin. The difference between the sulfínpyrazone and heparin groups was statistically significant (p < 0.01). Sulfínpyrazone in the dose used in this trial was not effective in reducing the incidence of deep vein thrombosis during elective general surgery.

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Section: Discussioncontrasting

confidence: 42%

Section: Discussioncontrasting

confidence: 41%

Section: Methodsmentioning

confidence: 99%

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Sulfinpyrazone and Postoperative Deep Vein Thrombosis

Gruber¹,

Buser²,

Frick³

et al. 1977

Eur Surg Res

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“…Thirteen trials [100][101][102][103][104][105][106][107][108][109][110][111][112] (1573 patients) assessed dextran as monotherapy, three trials 85,113,114 (420 patients) assessed dextran as adjunctive therapy (with heparin or an oral anticoagulant as background therapy) and two trials 61,115 (252 patients) assessed adding dextran to a mechanical compression method ( Figure 22).…”

Section: Dextran Effect Of Dextran On Dvtmentioning

confidence: 99%

“…The effect of dextran on PVT was reported in only six 101,104,106,107,112,114 of the 18 trials assessing dextran ( Figure 25). Overall, PVT occurred in 33 of 355 (9.3%) patients allocated to dextran versus 46 of 364 (12.6%) allocated control, corresponding to a reduction of 28% (21) in the odds of PVT (2p = NS).…”

Section: Effect Of Dextran On Proximal Venous Thrombosismentioning

confidence: 99%

Towards evidence-based guidelines for the prevention of venous thromboembolism: systematic reviews of mechanical methods, oral anticoagulation, dextran and regional anaesthesia as thromboprophylaxis

Roderick¹,

Ferris²,

Wilson³

et al. 2005

Health Technol Assess

268

151

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The Impact of Prophylactic Measures on Fatal Pulmonary Embolism

Atik¹,

Broghamer²

1979

Arch Surg

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Prevention of Postoperative Thromboembolism by Dextran 40, Low Doses of Heparin, or Xantinol Nicotinate

Cited by 86 publications

References 3 publications

Sulfinpyrazone and Postoperative Deep Vein Thrombosis

Sulfinpyrazone and Postoperative Deep Vein Thrombosis

Towards evidence-based guidelines for the prevention of venous thromboembolism: systematic reviews of mechanical methods, oral anticoagulation, dextran and regional anaesthesia as thromboprophylaxis

The Impact of Prophylactic Measures on Fatal Pulmonary Embolism

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